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《Joural of Biology》 2001-04
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Effect of short term of combined treatment with Gonadotropin-releasing hormone analogues and Growth hormone in central precocious puberty

FUNG Ling-jung,YAO Guong-ying,JING Yi-hua;et al (Shanghai Children's Hospital,Shanghai 200040,China)  
Objective: To recognize the changes in find adult height of girls with centrel precocious puberty(CPP)treated of combination by gonadotropin-releasing hormone analogues(GnRHa) and growth hormore(GH).Methods: The girls with CPP were treated by GnRHa and GH in half past year.The change of secondary sexual characteristics,advance of bone age,sex steroids and predicted fing adult height were abserved during treatment.Results: The results showed that drug could inhibit secondary sexual characteristics,advance of bone age was inhibited.The ratio of the chronologic age/bore age was rised from(mean 0.70)to(mean 0.84).The LH response to intravenous GnRH was reduced to prepubertal level from(mean 25.79 mlu/ml)to (mean 1.13mlu/ml).Plasma oestreadiol decreased to prepubertal level from (mean 64.87 pg/ml)to (mean 3.03pg/ml).Predicted final adult height increased significantly from pretreatment(mean 149.60cm)to(mean 156cm)P0.05.Condusion: The CPP was treated of combination with GnRHa and GH.That could not only inhibit secondary sexucl characteristics,but also increase find adult height effectively without any side effects.
【CateGory Index】: R725.8
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