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《Technical Acoustics》 2004-S2
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Assessment of Chronic Ischemic Myocardium before and after Transplantation of Bone Marrow Stromal Cell Transferred by Angiogenin Gene using Three-dimensional Echocardiography

XU Jing, ZHAO Bao-zhen, WANG Wei, et al. (Department of Ultrasound, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China)  
Objective: To investigate the value of Dynamic Three-dimensional echocardiography (DTDE) in detecting chronic ischemic myocardium before and after transplantation of bone marrow stromal cells (BMSCs) combined with angiogenic gene transfer. Methods: Four weeks after chronic ischemic myocardium models were set up, groupⅠ-Ⅳ were intramyocardially administrated by BMSCs transferred by Adenovirus mediated Angiogenin gene(Ad·ANG), Ad·ANG, BMSCs and phosphate buffer(PB) respectively. Four weeks later, Pathological investigation of their hearts was performed. DTDE was performed at normal state, 4 weeks after Ameroid placement and 4 weeks after administration respectively. Results: The end-diastolic and end-systolic volume of left ventricle (LVEDV、LVESV) are all increased and the ejection fraction (LVEF) all decreased 4w after Ameroid placement (P0.01). After administration, group Ⅳ remained increased volumes and decreased LVEF compared with that before administration and that of other administrated groups (P0.05). The greatest increase of LVEDV、LVESV and greatest decrease of LVEF were found in Group Ⅰ in all administrated groups. Conclusions: DTDE is a feasible approach to assess LV volumes and systolic function changes in chronic ischemic myocardium before and after gene transfer and cell transplantation therapy.
【CateGory Index】: R541
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【Citations】
Chinese Journal Full-text Database 2 Hits
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【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 ZHAO Bao-zhen, XU Jing, WANG Wei, et al. (Department of Ultrasound, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China);Evaluation of Chronic Ischemic Myocardium before and after Transplantation of Bone Marrow Stromal Cell Transferred by Angiogenin Gene by Real-time Myocardial Contrast Echocardiography[J];Technical Acoustics;2004-S2
2 ZHANG Xiu-zhou, LI Wei-hua, LIU Xue-ping (Deportment of Senility, Shandong Provincal Hospital, Jinan 250021, China);Bone Marrow Stem Cell Transplantation for Myocardial Infarction[J];Chinese Journal of Thrombosis and Hemostasis;2005-04
3 XU Jing,ZHAO Baozhen,HUANG Shengdong, et al. Department of Ultrasound Changhai Hospital, The Second Military Medical University, Shanghai 200433, China;Evaluation of chronic ischemic myocardium before and after transplantation of bone marrow stromal cell transferred by angiogenin gene with three-dimensional echocardiography[J];Shanghai Medical Imaging;2005-01
4 CHENG Min GUO Huai-lian HU ANG Li. (Department of Neurology,People's Hospital,Peking University,Beijing 100044,China);The kinetic change of the expression level of angiogenin in the reversible-ischemic rat brain[J];Journal of Apoplexy and Nervous Diseases;2007-03
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6 LU Ren-rong,CHEN Liang-long,ZHONG Ling,et al.Department of Cardiology,Affiliated Sanming First Hospital of Fujian Medical University,Sanming(365000),Fujian,China;Transplantation of Allogenic Mesenchymal Stem Cell Transfected With Connexin 43 Gene in the Treatment of Acute Myocardial Infarction in Rats[J];Chinese Circulation Journal;2008-06
7 XU Jing 1 *, ZHAO Bao-zhen 1, HUANG Sheng-dong 2, WANG Wei 1, JIA Bao-cheng 2, CUI Yong 2, GONG De-jun 2, ZHOU Gui-hua 1, WANG Hong 1 (1.Department of Ultrasound,2.Institute of Cardio-thoracic Surgery, Changhai Hospital, Second Military Medical University,Shanghai 200433, China);Assessment of chronic ischemic myocardium before and after transplantation of bone marrow stromal cell transferred by angiogenin gene using dynamic three-dimensional echocardiography[J];Chinese Journal of Medical Imaging Technology;2005-05
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Tong Xiaoming,Sun Baozhen,Gao Qingping,et al. Zibo City Hospital,Zibo,255036 ;Plasma Level of Atrial Natriuretic Factor and Changes of Left Atrial Function in Patients with Coronary Heart Disease[J];Chinese Journal of Physical Medicine;1998-01
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