Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Shaoxing University(Natural Science)》 2018-03
Add to Favorite Get Latest Update

Preparation and Application of L-valine Substituted Norcantharidin Derivatives Containing Pyridazine Ketone

LI Qian;WANG Wei;School of Chemistry and Chemical Engineering,Shaoxing University;Yuanpei College,Shaoxing University;  
In this paper,the pyrazole ring was introduced into the structure of L-valine replaced norcantharidin in C5 and C6positions by 1,3-dipolar ring addition method;,the structure of pyridazine was then introduced into the structure of pyridazine through reaction with tryptoprozone containing azone structure; the Lvalrine containing pyridazine ketone was generated to replace the derivatives of norcantharidin. This derivative has a variety of biological activities,thus used in the development and research of potential drugs.
【Fund】: 国家自然科学基金资助项目(81202411)
【CateGory Index】: TQ25;TQ460.1
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 3 Hits
1 TANG Jun1,2,XIANG Guang-ya1(1.Pharmacy School of Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;2.Department of Pharmacy Engineering of Huaxia College,Wuhan University of Technology,Wuhan 430223,China);Synthesis and COX-2 inhibitory activities of 1,5-diaryl pyrazole derivatives[J];中国药物化学杂志;2008-01
2 CAO Jing-Hua, XU Bo, LI Min, WU De-Zhu, HUANG Wei, CUI Jing-Rong State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Science, Peking University, Beijing, 100083, P. R. China;Effect of Norcantharidin's Derivative Nd3 on Proliferation of Human Ovarian Cancer Cell Line SKOV3 and Its Possible Mechanisms[J];癌症;2007-04
3 ZHAO WeiGuang, CHEN Han Song, LI Zheng Ming, HAN Yu Fen YAN Han, LAI Jun Ying, WANG Su Hua (Institute of Elemento organic Chemistry, Nankai Universty, Tianjin 300071, China);Synthesis of Pyrazolyl-heterocycles and Their Fungicidal Activities[J];高等学校化学学报;2001-06
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 XU Chang;AN Yue;ZHU Haotian;LIN Yue;WANG Rinan;School of Chemistry and Chemical Engineering,Liaoning Normal University;;Synthesis,Crystal Structure and Biological Activities of 3-Substituted-1-( 5-aryl-1,3,4-thiadiazol-2-yl)-1H-pyrazole-4-formaldehyde[J];应用化学;2015-07
2 LI Baoxia;ZHANG Peng;YANG Yuhong;MENG Runsha;LIU Fuqian;WANG Li;JIANG Jianwei;Department of Biochemistry,Medical College,Jinan University;Department of Laboratory,Guangzhou Panyu Central Hospital;;Inhibitory effect of Silibinin combined with 5-FU on MGC-803 gastric cancer cell proliferation and the mechanisms[J];暨南大学学报(自然科学与医学版);2014-02
3 CHEN Shi-jiang;LU Zeng-hui;LIAO Yu-feng;HUANG Ge;YIN You-ping;Chongqing Academy of Chinese Materia Medica;School of Life Science,Chongqing University;;Study on Molecular Phylogeny of Seven Species of Chinese Blister Beetle Based on COI Gene Sequence[J];西南农业学报;2013-05
4 ZHANG Peng;LIN Chen;ZHANG Xiaokai;LI Baoxia;TAN Dandan;WANG Li;JIANG Jianwei;Department of Microbiology and Immunology,Medical College;Department of General Surgery,the First Affiliated Hospital;Department of Biochemistry,Medical College,Jinan University;Department of Laboratory,Guangzhou Panyu Central Hospital;;Norcantharidin inhibit cell growth and induces apoptosis in gastric cancer MGC-803 cell lines[J];暨南大学学报(自然科学与医学版);2013-04
5 Jiao Yuanhong,Zhang Qian,Jiao Ping(School of Chemical and Materials Engineering,Hubei Polytechnic University,Huangshi Hubei 435003);Synthesis and Crystal Structure of 5-(Thiophen-2-yl)-3-(Trifluoromethyl)-1H-pyrazole[J];湖北理工学院学报;2012-06
6 YU Ge-jie 1,2,SHI Yuan-liang 1,GU Hui-juan 1,2,WANG Ting-ting 1,2,WEI Zhan-bo 1,2(1.Institute of Applied Ecology,Chinese Academy of Sciences,Shenyang 110016,China; 2.Graduate University of Chinese Academy of Sciences,Beijing 100039,China);Comparison on the Effects of Three Pyrazoles Nitrification Inhibitors on the Transformation for Urea-N in Black Soil[J];土壤通报;2011-02
7 YU Ge-jie1,2,SHI Yuan-liang1,GU Hui-juan1,2,WANG Ting-ting1,2,WEI Zhan-bo1,2(1.Institute of Applied Ecology,Chinese Academy of Sciences,Shenyang 110016,China;2.Graduate University of Chinese Academy of Sciences,Beijing 100039,China);Effects of CMP-nitrification Inhibitor on Urea-N Transformation[J];华北农学报;2010-S1
8 XU Xin1,PENG Lin-tao2(1.Department of Pathology;2.Department of Surgery,Xingtai People's Hospital,Xingtai 054031,China);Effect of norcantharidin on apoptosis of human esophageal cancer cell Eca-109 and its possible mechanism[J];肿瘤;2010-08
9 WANG Jing-fang, WANG Can-jun, ZHUANG Yu-guo (Department of Pharmaceutical and Chemical Engineering, Taizhou University, Linhai 317000, China);Synthesis of 1,3-Diphenyl-4-formylpyrazole under Microwave Irradiation[J];浙江化工;2010-06
10 YU TING, LIU Dong-wu,,CHEN Zhi-wei;Clinical application and mechanism of Cantharidin and it's Ramification[J];生命科学仪器;2009-02
【Secondary Citations】
Chinese Journal Full-text Database 9 Hits
1 QU Wen-zhi, CHEN Jing, SUN Yu-hua, LIANG Jian (Department of General Surgery, the Fourth Affiliated Hospital of China Medical College, Shenyang, Liaoning 110032, P.R.China);Relationship between ratio Bcl-2/Bax gene and biological behavior of breast cancer[J];中国现代医学杂志;2006-07
2 SHEN Manli, FENG Yongdong, GAO Chun, TAO Deding, GONG Jianping. Molecular Medical Center, Tongji Hospital, Tongji Medical College, Central China University of Science and Technology, Wuhan 430030, China;Unscheduled expression of cyclin B1 in G_1-phase among cultured and clinical tumor cells[J];中华肿瘤杂志;2002-03
3 CHEN Han Song, LI Zheng Ming , LI Jia Feng [WT5”BX](State Key Laboratory of Elemento Organic Chemistry, Institute of Elemento Organic Chemistry, Nankai Univeristy, Tianjin 300071, China) [WT5HZ];Synthesis of 2-Pyrazoyl-5-substituted-1,3,4-oxadiazoles and Their Biological Activities[J];高等学校化学学报;2000-10
4 Liu Xiaolan (刘晓兰), Chen Jiaxu (陈家旭), Liu Yan (刘 燕), et al. (Beijing University of Traditional Chinese Medicine, Beijing 100029);Effect of Norcantharidin on Apoptosis of HL60 Cells[J];北京中医药大学学报;2000-04
5 Han Yufen Chen Hansong (Institute of Elemento Organic Chemistry, Nankai University, Tianjin 300071);Studies on the leaf segment method in vitro inoculation for testing pesticide ativity to Rhizoctonia solani[J];植物保护;1999-05
6 Tang Longying,Wang Zhaomei,Zheng Qinyue,Mi Heming,Zhu Linxian,Cao Yingying(Depar tment of Gynecology and Obstetrics,Changhai Hospital, Second Military Medical U niv ersity,Shanghai,200433);In vitro inhibitory effect of norcantharidine on ovarian carcinoma 3AO a nd AO cells[J];第二军医大学学报;1999-02
7 Bai Zaisu Wang Daxiang (Shenyang Research Institute of Chemical Industry,Shenyang 110021);Heterocyclic Compounds, Genetic Engineering and Pesticides in 21 Century[J];农药;1998-06
8 CHEN Han Song, LI Zheng Ming (Institute of Elemento Organic Chemistry, Nankai University, Tianjin, 300071);One Pot Synthesis and Biological Activity of 2,5 Dipyrazolyl 1,3,4 oxadiazoles[J];高等学校化学学报;1998-04
9 LI Zheng-Ming; CHEN Han-Song; ZHAO Wei-GuangZHANG Kai; HUANG Xing-Sheng(Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071);Synthesis and Biological Activity of Pyrazole Derivatives[J];高等学校化学学报;1997-11
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved