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《Journal of Shaoxing University(Natural Science)》 2018-03
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Preparation and Application of L-valine Substituted Norcantharidin Derivatives Containing Pyridazine Ketone

LI Qian;WANG Wei;School of Chemistry and Chemical Engineering,Shaoxing University;Yuanpei College,Shaoxing University;  
In this paper,the pyrazole ring was introduced into the structure of L-valine replaced norcantharidin in C5 and C6positions by 1,3-dipolar ring addition method;,the structure of pyridazine was then introduced into the structure of pyridazine through reaction with tryptoprozone containing azone structure; the Lvalrine containing pyridazine ketone was generated to replace the derivatives of norcantharidin. This derivative has a variety of biological activities,thus used in the development and research of potential drugs.
【Fund】: 国家自然科学基金资助项目(81202411)
【CateGory Index】: TQ25;TQ460.1
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