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《Journal of Shaoxing University(Natural Science)》 2018-03
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Determination of Vitamin B_6 Content in Tablets by QNMR

LU Ruijuan;XU Qiumei;Analytical and Testing Center,Shaoxing University;  
To establish nuclear magnetic resonance(NMR) method for content determination of vitamin B_6,1H-NMR spectra were obtained with a Bruker 400 MHz spectrometer(AVANCEⅢ) at 298 K. For each sample,16 times of scans were recorded with the following parameters: the pulse sequence zg 30,delayed time of 20 s. Vitamin B_6 was mixed with maleic acid as internal standard in D_2O. Results show as follows:the average content of vitamin B_6 and RSD are 15. 29% and 2. 4% respectively; the average recovery is99. 39%; the average content of vitamin B_6 in each tablet is 9. 327 mg within the scope specified in the pharmacopoeia. The conclusion is that this method is simple and accurate for quantitative analysis of vitamin B_6 in tablets.
【Fund】: 绍兴文理学院科研资助项目(2015LG1003)
【CateGory Index】: O657.2;TQ460.72
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