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Anti-Oxidative Effect of Gynostemma and Hawthorn Extracts on the Aging Mouse Model Induced by D-galactose

YAN Yan,GUO Jie,YANG Fei,XUE Wei(Shangdong Provincial Centre for Disease Control and Prevention,Jinan 250014,China)  
Objective To study the mechanism of anti-oxidative activity and the anti-oxidative effect of gynostemma and hawthorn extracts on aging mouse model.Methods The aging mice were induced by ip injection of D-galactose for 8 weeks and were given the different doses of gynostemma and hawthorn extracts.Eight weeks later,malondialdehyde(MDA),superoxide dismutase(SOD) and glutathione peroxidase(GSH-P_X) in sera and livers were detected.Results Gynostemma and hawthorn extracts not only significantly reduced the contents of MDA but also increased the activity of GSH-P_X in sera and livers of the aging mice.Conclusion Gynostemma and hawthorn extracts have good anti-oxidative effect.
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