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《Experimental Technology and Management》 2012-03
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Study of multielement composite indicator on lead accumulation in kidney and femur

Yan Lailai1,Wang Jingyu1,Liu Liping2,Niu Gang3,Wang Xiaoxia3,Ouyang Li1(1.School of Public Health,Peking University,Beijing 100191,China;2.Beijing Center for Disease Prevention and Control,Beijing 100013,China;3.Beijing N&N Gene-Tech Company,Ltd.,Beijing 100088,China)  
Objective By analyzing the relations between multielement in the blood and lead in the kidney and femur,a group of multielement composite indicators to indicate lead accumulation of kidney and femur is looked for.Methods Senventy-five healthy 4-week-old male SD rats were randomly divided into 25 groups,adopting an exposure method of "large dose range,a small concentration interval." One rat per group was selected randomly at the beginning of the experiment stage of 40,80,120 days.Under ether anesthesia,blood from femoral artery and kidney and femur were obtained,Concentrations of elements were determined by the inductively coupled plasma mass spectrometry(ICP-MS).Results Concentrations of blood lead,kidney lead,femur lead changed with increasing lavage dosage,however,the trends were different.Correlations between blood lead and kidney lead or femur lead change with exposure time.Correlations between other elements or element ratios and kidney lead or femur lead were significant statistically,whose coefficients were higher than correlation coefficients between a single element and kidney lead or femur lead.Conclusion The single blood lead indicator can't reflect condition of lead accumulation in the body accurately.Multielement composite indicators are means to estimate the concentrations of organ lead effectively.
【Fund】: 新教师科研启动基金(BMU20090501-123);; 国家自然科学基金(30972434)
【CateGory Index】: R114
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