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《Experimental Technology and Management》 2012-03
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Study of multielement composite indicator on lead accumulation in kidney and femur

Yan Lailai1,Wang Jingyu1,Liu Liping2,Niu Gang3,Wang Xiaoxia3,Ouyang Li1(1.School of Public Health,Peking University,Beijing 100191,China;2.Beijing Center for Disease Prevention and Control,Beijing 100013,China;3.Beijing N&N Gene-Tech Company,Ltd.,Beijing 100088,China)  
Objective By analyzing the relations between multielement in the blood and lead in the kidney and femur,a group of multielement composite indicators to indicate lead accumulation of kidney and femur is looked for.Methods Senventy-five healthy 4-week-old male SD rats were randomly divided into 25 groups,adopting an exposure method of "large dose range,a small concentration interval." One rat per group was selected randomly at the beginning of the experiment stage of 40,80,120 days.Under ether anesthesia,blood from femoral artery and kidney and femur were obtained,Concentrations of elements were determined by the inductively coupled plasma mass spectrometry(ICP-MS).Results Concentrations of blood lead,kidney lead,femur lead changed with increasing lavage dosage,however,the trends were different.Correlations between blood lead and kidney lead or femur lead change with exposure time.Correlations between other elements or element ratios and kidney lead or femur lead were significant statistically,whose coefficients were higher than correlation coefficients between a single element and kidney lead or femur lead.Conclusion The single blood lead indicator can't reflect condition of lead accumulation in the body accurately.Multielement composite indicators are means to estimate the concentrations of organ lead effectively.
【Fund】: 新教师科研启动基金(BMU20090501-123);; 国家自然科学基金(30972434)
【CateGory Index】: R114
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Chinese Journal Full-text Database 6 Hits
1 WANG Zhang-jing,CHEN-Huan,LI Feng-pingSchool of Public Health,Fujian Medical University,Fuzhou 350004,China;Effects of Lead-Exposed on the Levels of Calcium and Zinc in vivo and in vitro[J];Journal of Fujian Medical University;2005-04
2 QIN Junfa(Shanghai Institute of Applied Physics,Chinese Academy of Sciences,Shanghai 201800,China);Relationship between Hair Lead and Blood Hair[J];Guangdong Trace Elements Science;2010-08
3 WANG Xue-fei~1, ZHANG Jie~2, ZHANG Zhi-yong~1, LIU Nian-qing~1, ZHAO Bao-lu~2, CHAI Zhi-fang~1 1. Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, the Chinese Academy of Sciences, Beijing 100039, China; 2. Center for Brain and Cognitive Sciences, Institute of Biophysics, the Chinese Academy of Sciences, Beijing 100101, China;Effect of Lead on Zn, Cu, Fe and Mn Content in Rats[J];Journal of Nuclear and Radiochemistry;2004-04
4 CHAI Wei-zhong, WANG Jing-yu, OU Yang-li et al (Department of Nutrition and Food Hygiene, Peking University, Beijing 100083,China);Current status and limitations in life-element studies as well as the significance of whole-element study from a viewpoint of the development history and interactions of life element[J];Studies of Trace Elements and Health;2003-05
5 LI Dong-yang,ZHOU Yan,LIU Qing-guo (Changsha Medical College,Hengyang,Hunan 421001,China);Changes of contents of certain microelements in workers exposed to lead[J];Studies of Trace Elements and Health;2006-04
6 TAN Ling1,LIU Li-ping2,YAN Lai-lai1,NIU Gang3,WANG Xiao-xia3,ZENG Jing1,LIU Ya-qiong1,WANG Jing-yu1 (1.Central Laboratory,School of Public Health,Peking University,Beijing 100091,China;2.Beijing Center for Disease Control and Prevention,Beijing 100013,China;3.Beijing N&N Gene-Tech Company,Ltd.,Beijing 100088,China);29 kinds of element contents and their ratio with accumulation levels of lead and lead in rats exposed to time-related study[J];Chinese Journal of Health Laboratory Technology;2010-06
Chinese Journal Full-text Database 10 Hits
1 WANG Tian-cheng,HE Xiao,ZHANG Zhi-yong,et al.Department of Clinical Laboratory,3rd Hospital of Peking University,Beijing 100083,China;Effect of Lanthanum Subchronic Exposure on Metabolism of Calcium,Magnesium and Iron in Rats[J];Journal of Environment and Health;2007-04
2 DONG Jiao1, LIU Zheng-hong2, XIONG Hai-jin1 (1. Department of Pediatrics, People' s Hospital of Gansu Province; 2. Clinical Medi- cal College of Lanzhou University, Lanzhou 730000, Gansu, China);Study of the levels of lead and eight trace elements among preschool children in Jinchang[J];Journal of Clinical Pediatrics;2008-12
3 LI Xian-kuan,WANG Bing,ZHENG Yan-chao,HE Hua,XU Bao-li (Liaoning University of Traditional Chinese Medicine,Dalian 116600,Liaoning,China);Analysis on the Content of Inorganic Elements of Fructus Schisandrae in Liaoning Province[J];Liaoning Journal of Traditional Chinese Medicine;2012-06
4 Yan Lailai1,Ouyang Li1,Xie Qing1,Liu Qingfen2,Zhu Hongda2,Wu Quan2,Wang Jingyu1,3(1.School of Public Health,Peking University,Beijing 100191,China;2.Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College,Tianjin 300192,China; 3.Center of Medical and Health Analysis Center,Peking University,Beijing 100191,China);Study on difference and relation of heavy metals in adult dietary and blood in four cities[J];Experimental Technology and Management;2011-08
5 HE Rui-fang~1,ZHANG Yan~2,YANG Yan-xu~3,LI Xiao-juan~1,CHENG Yuan~1,LI Dong-liang~1 (1.Department of Physiology and Neurobiology;2.Functional Laboratory;3.Department of Public Health,Xinxiang Medical College,Xinxiang 453003,China);Changes of Lead,Zinc,Copper,Iron and Calcium in Blood of Lead Poisoned Infantal Mice[J];Journal of Applied Clinical Pediatrics;2006-14
6 CHEN Hong-hui~1,FU Xue~2,JIANG Yue-ming~2(1.Prevention and Health Section,Guangxi Autonomous Region People's Hospital,Nanning 530021,China;2.Dept.of Occupational Health and Toxicology,Guangxi Medical University,Nanning 530021,China);Effects of Lead on the Metabolisms of Several Metal Elements in Children's Blood[J];Railway Occupational Safety Health & Environmental Protection;2007-04
7 LI Mu-yan~1,OU Shi-yan~2,JIANG Yue-ming~2,et al.(1.Medical Scientific Research Center,Guangxi Medical University,Nanning 530021,China;2.Dept.of Environmental,Occupational and Nutrimental Health,Guangxi Medical Unviersity,Nanning 530021,China);The Lead Concentration and Associations between It and other 5 Trace Elements in Blood among 5843 Children from a Hospital Clinic of Guangxi[J];Railway Occupational Safety Health & Environmental Protection;2008-02
8 LI Wei,TAN Xiang-Shi(Department of Chemistry/Institutes of Biomedical Sciences,Fudan University,Shanghai 200433,China);Manganese trafficking, metabolism and homeostasis[J];Chinese Bulletin of Life Sciences;2012-08
9 LIU Hui,MA Shuan-zhu(Baotou medical college of Inner Mongolia of science and technology 014010,China);The Equilibrium of Trace Elements and Excluding Lead[J];Studies of Trace Elements and Health;2006-05
10 SUN Jian-min,FAN Hong,CUI Meng,et al(College of Chemistry and Environmental Science,Hebei University,Baoding 071002,China);Determination of Eight Metal elements in Soyabean Oil[J];Studies of Trace Elements and Health;2007-03
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 FENG Fu-jian 1,WANG Lan 1,YU jiang-ping 1 LI Lan-fang 2,DAI Bao-qiang 2,CAO Xiu-fang 2 (1.Institute of Geographical Sciences and Nature Resources Research CAS,Beijing 100101,China; 2.China Academe of Traditional Chinese Medical Science);Effect Research of Lead Poisoning on Some Metals Levels in Rats Body[J];Trace Elements Science;2001-04
2 YU Yu-mian,DONG Fen-qiang,LIU Chun-ying et al (Experimental Research Centre,Guangdong Industrial University,Guangzhou 510090,China);Correlative Study on the Trace Elements in Hair and Blood of Infant in Ningbo and Haining Portion District,Zhejiang Provence[J];Trace Elements Science;2001-10
3 QIN Jun fa 1,LI Zeng xi 2,YE Fu yuan 3,WANG Yong xian 1 (1.Shanghai Institute of Nuclear Research,The Chinese Academy of Scienes,Shanghai 201800,China; 2.Chinese National Analysis Centre of Guangzhou,Guangzhou\ 510070,China; 3.Shanghai Chinese;Brief History of Clinical Application Development of Hair Element Analysis[J];Trace Elements Science;2002-04
4 Weimin Hu 1,ZHENG Xing quan 2 (1.Vancouver Island Health Authority,Victoria,BC,Canada;2.Institute for Environment Hygiene and Health Related Product Safety,China Center for Disease Control);Effects of Different Hair Washing Methods on the Contents of Lead,Cadmium,Chromium,and Mercury in Human Scalp Hair[J];Journal of Labour Medicine;2002-06
5 Gu Yongzu(Department of Chemistry, Sichuan University, Chengdu, 610064)Gu Xinping(The 3rd People′s Hospital of Chengdu, 610031);Environmental Lead Pollution and Health[J];Sichuan Environment;1998-01
6 Lü Jing, Zhang Lili, Dai Yaohua,Liu Guilan, et al.Institute of Occupational Medicine ,Chinese Academy of Preventive Medicine, Beijing 100050, China;Effects of low-level lead exposure on neurobehaviour developmentin 1-3 year-old children and the intervention guideline[J];Journal of Hygiene Research;2002-01
7 Zheng Xingquan;Liu Jianrong;Dong Bing;Cai Shilin(Inst.of Environmental Health Monitoring, Chinese Academy of Preventive Medicine, Beijing 100050, China);Studies on reference value for lead and cadmium of blood,hair and tissues of adults in Beijing[J];JOURNAL OF HYGIENE RESEARCH;1995-06
8 Qu Ning;Gao Junquan;Li Weidong;Tian Yuan;et al. (Institute of Nutrition and Food Hygiene,Chinese Academy of Preventive Medicine,Beijing 100050,China);The Chinese Total Diet Study in 1992-Macro Elements and Trace Elements[J];JOURNAL OF HYGIENE RESEARCH;1997-02
9 You Zhihua,Hu Xiangyun,Chao Mingxia et al (Nanchang Railway Central Hospital,Nanchang 330003,China);An investigation on blood Lead level and affacting factors of 883 children in Nanchang city[J];Studies of Trace Elements and Health;2001-02
10 ZHENG Ming-ping,WEI Shou-zhong,SHUI Hua,et al (The Ningde Municipal Hospital,Ningde 352100,China );A study on blood lead level of 970 children in Fujian Ningde[J];Studies of Trace Elements and Health;2003-02
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