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The Research of Lymphocyte Glucocorticoid Receptor. T Cell Subpopulation and Serum Immunoglobulin in Child Patients with Asthma

Research Section of Children' Blood Tumor, West Chinese Medical University Liao Qingkui, et al.  
Objectives To search for the relationship between Children' asthma and lymphocyte glucocorticoid rece-ptor (GCR). T Cell subpopulation and serum immunoglobulin. Design Case-control research. Patients and Other Panticipants Thirty-four Child patients with asthma (Observation group),Thirty-four health childreu (Control group), the sexesand ages are same as observation group. Interventions The blood of all of the patients and other participants were drawn from peripheral andfemoral vein at 8 o'clock in the morning, anticoagulated by heparin for measurement. Measurements and Main Results The GCR. T cell subpopulation and serum immunoglobulin were deter-mined by radioreceptor assay. microcytotoxicity assay and semi-automatic biochemical analysis instrumentrespectively. The GCR levels of observation group and control group are 3028±1402 and 5288±2238 com-bining site/lymphocyte respectively(t=4.99, P0.01), thc percentages of CD. are 43.03+7.07. 51.26±5.89 respectively (P0.01), the CD_4 are 29.91±6.47.36.85±7.57 respectively (P0.01), the CD_8are 18.56±3.68、23.41±6.82 respectively (P0.01), the value of CD_4/CD_8 is 1.63±0.31、1.65±0.41respectively (P0.05).IgG. IgA and IgM levels are no significant difference between the two groups instatistics. Conclusions The GCR levels aud all of T cell subpopulation percentages are decreased obviously in thechild patients with asthma. It's indicated that the cytoimmunity is deficiency in child patients with as-thma. It's suggested that it would be effective to use the drug of activating GCR for treating children'asthma.
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