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Children' Asthmatic Diseases and the Changes of Cyclic Nucleotide

Children' Hospital of Chongqing Medical University Zhang Ruyi, et al.  
Objective To search for the relationship between asthmatic diseases and the changes of cyclic nucleotidein children. Design Case-control research. Patients and Other Participants There are 25 patients with hronchial asthma, 21 patients with asthmaticbronchitis and 25 patients with bronchiolitis. There are 60 healthy children in control group. Interventions The blood of all of the patients and other participants had been drawn at 8~10 o,clockin the morning. Plasma cAMP. cGMP had been determined by radioimmunoassay and the values of cAMP/cGMP had been shown. Main Results There are no relationship between the levels of cAMP. cGMP and the age in kealth chi-ldren. The levels of cAMP in control group. bronchial asthma group. asthmatic bronchitis group and bron-chiolitis group are 21.483±6.635, 14.80±3.449、17.366±5。430 and 18.344±5.159 nmol/L respectively, the cGMP levels are 3.406±0.919、4.468±1.22、4.32±1.497 and 4.264±1. 20nmol/L. The levels of cAMPcGMP and the values of cAMP/cGMP in all of the disease group have significance difference comparingwith control group. Conclusions Decreased levels of cAMP and the values of cAMP/cGMP, increased levels of cGMP arenot only a important reason of asthma attack, but also the asthmatic bronchitis and bronchiolitis.
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