Growth hormone levels in perinatal period and long term follow up of growth development in SGA infants
GAO Ping-Ming;LIU Wan-Jun Affiliated Tongji Hospital, Tongji Medical University
Objectives To search for the growth hormone (GH) levels in small-for-gestational age (SGA) infants,appropriate-for-gestational age (AGA) in fants and pregnant women. The growth and development of SGAinfants at the age of 10～56 months were investigated. Methods Cace-control research. The growth normone levels of pregnant women and newborn infantswere determined by radioimmunoassay. The growth and development of SGA infants at the age of 10～56months were investigated. Results Mean serum GH levels, newborn infants is 15.87±13.42ng/ml, pregnant women is. 3.85±2.18ng/ml. SGA newborn infants are 16.13±13.71 (before intake colonidine) and 24.80±17.50ng/ml (after in-take colonidine). AGA newborn infants are 16.47±17.47 (before intake colonidine) and 22.30±19.11ng/ml(after intake colonidine). The mean serum GH levels of the 1st, 3rd and 5th day after birth are 17,00±14.84, 19.40±18.08 and 11.87±10.58ng/ml respectively. 56 SGA infant: were followed up at age of 10～56 months compared with 56 AGA infants, 41.07% (lenth), 35.71% (Weight), 26.79% (circumference)were still below tbe 10th percentile in SGA infants, while 14,28%, 1.79% and 16.07% below the 10th pe-rcentile respectively in AGA infants. Conclusion The levels of serum GH are at high level in newborn infants which is significantly higherthan the levels of pregnant women. GH concentration persists at a high level in the first five days. Thereis no significant difference between the SGA and AGA newborn infants. The growth development of SGAinfants is poorer than that of AGA infants.