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Changes of IgE Levels and the disorder of IL-4/IFN-γ in Child patients with asthma

FU Zhou;YANG Xi-Qiang ; Li Cheng-Rong; ZHANG Liang-Ji ;WANG Li-Jia;ZHANG Yuan-Wei ;HE Jia-Min (The Children' s Hospital, Chongqing Medical University, Chongqing, China)  
Objectives To search for the relationship among UM-4, IFN-γ and IgE in child patients with astllma.Mehtods There were 20 child patients(10 males and 10 females) with asthma, 15 norrnal children(8 males and 7 females). The venous blood was drawn, and the serum IL-4. IFN-Y fo IgE were determined by ELISA method. The results of determination were analysed stalistically.Results In the 20 patients with asthnla and 15 normal children,the levels of serum IL-4,IFN-γ, ILu4/IFN-γ and IgE were 123. 28± 61. 33 vs 53. 82±19. 88ng/L(P<0. 01), 703. 21 ±96. 06 vs 1575. 10±690. 69ng/L(P<0. 01 ), 0. 18±0. 12 vs 0. 06±0. 04 (P<0. 01 ), and 782. 24±441. 69 vs 176. 51 ±82. 72 kU/L(P<0. 01 ) respectively. The results of linear correlation analysis showed that there were obvious correlation between IL-4, IFN-T, IL-4/IFN-γ and IgE, and obviously positive correlation between IL-4 and IFN-γ.Conclusions The values of IL-4, IgE and IL-4/irN-γ are increased but IFN-γ decreaho significantly: The disorder of IL-4 /IFN-γ and increasing level of IgE could play an important role in attack of chi]dren's asthma.
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