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The effect of oral vitamin K_1 on protein induced by vitamin K absence Ⅱ in newborn infants

LIANG Youling ,LIN Chaoqiong, LU Jie The Child and Maternity Hospital of Guangxi Zhuang Autonomous Region,Nanning 530003,P.R.China  
Objective To study the changes of the concentration of PIVKA Ⅱ (protein induced by Vitamin K 1 absence Ⅱ) after different multiple oral doses of Vitamin K 1 (hereafter referred to as VK 1) given to normal newborn infants and to explore the optimal oral dose of VK 1 for prtecting newborn infants from VK 1 deficiency.Methods 101 cases of normal newborn infants were randomly divided into three groups. Group A took 2.5 mg VK 1 orally,group B took 5 mg VK 1 orally and the group C as the controls without VK 1 intake. Umbilical blood was collected at birth. The concentration of PIVKA Ⅱ was measured by enzyme linked immunosorbent assay (ELISA) and it was done again three days later. The normal concentration of PIVKA Ⅱ is below 2 mg/ml (PIVKA Ⅱ2 mg/ml). If higher it means the deficiency of VK.Results The number of cases with PIVKA Ⅱ≥2 mg/ml reduced from 8 to 4 in group A with 2.5 mg;The number of cases with PIVKA Ⅱ≥2 mg/ml reduced from 11 to 2 in group B with 5 mg and the number of cases with PIVKA Ⅱ≥2 mg/ml reduced from 11 cases to 8 in the control group. There was no significant difference between group A and group B (P0.05), but there was significant difference between the oral VK 1 group and the control group (P0.05).Conclusion There are no changes or significant difference for PIVKA Ⅱ between group A and group B who were given oral intake of VK 1.
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