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An investigation of s-NSE and BAEP in children with congenital heart disease

ZHAO Congmin ,WANG Chunyan, ZHANG Yuping, et al. The Pediatrics Department of Xinqiao Hospital, the Third Military Medical University, Chongqing 400037, P.R. China  
Objective To evaluate the value of brainstem auditory evoked potential(BAEP)and serum neuronal specific enolase (s NSE) during the heart surgery on the children with congenital heart disease(CHD) under extracoperal circulation.Methods 1.BAEPs were examined in 20 children with CHD before and after heart beating under extracorporeal circulation.2.The s NSE levels were detected in 20 of CHD operated under heart beating condition and others under heart arrested condition.Results Compared with normal children, Ⅲ Ⅴ and Ⅰ Ⅴ interpeak latencies (IPL)in CHD patients were significantly prolonged in cyanotic CHD (CCHD) (P0.05).There was significant difference between CCHD and non cyanotic CHD( NCCHD) inⅠ Ⅴ IPL(P0.05). The s NSE levels were elevated 2 hours after operation compared with those 24 hours before operation(P0.001). There was significant difference in the average of s NSE compared with 24 hours before operation on the 7th day after operation(P0.05). There was significant difference between heart beating group and heart arrested group in the average value of s NSE at 2 hours or 7 days after operation(P0.001,P0.05).Conclusions The CCHD might be complicated with the damage to the cerebral function .The changes of s NSE levels could indicate functional brain damage during the surgical procedures under extracorporeal circulation. The surgery in heart bea ting condition may be better than that in heart arrested condition as to protect the brain.
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