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Clinical pathologic significance and the appraisal of prognoses in children with primary nephrotic syndrome

XIAO Huijie , LIU Jingcheng, CHEN Hua Department of Pediatrics, the First Hospital of Peking University,Beijing 100034, P.R.China  
Objective To study the relationship between clinical pathologic significance and the appraisal of prognoses in school aged children suffering from primary nephrotic syndrome.Methods The clinical and pathologic data of 32 school aged cases suffering from primary nephrotic syndrome during 1995~1999 year in our hospital were retrospectively analyzed.Renal tubulointerstitial changes were divided into IV grades.Results Mesangial proliferative glomerulonephritis is the main pathologic change in all the specimen studied , accounted for 65 %(21/32). No significant difference was found in renal tubulointerstitial changes among different clinical phenotypes. It was suggested that tubulointerstitial changes varied according to the seriousness of glomerular lesions, however that cases were not always the same.Conclusions Mesangial proliferative glomerulonephritis still ranked the top in pathologic patterns of all the specimen studied. In our brief observation, tubulointerstitial changes may act as a major determinant in the progression of renal damage. β 2 microglobulin examination may be a sensitive indicator of tubulointerstitial function.
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