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Neutrophil CD11b expression in healthy neonates

CUI Yingbo, DU Lizhong, TANG Yongmin, et al. Ningbo Women & Children′s Hospital, Ningbo 315012, P.R.China  
Objective To explore neutrophil functions of neonates at the molecular level.Methods Neutrophil CD11b median fluorescence intensity(MFI) in 33 normal full term neonates was measured by using whole blood method with flow cytometry and dir ect immunofluorescence technique. 10 healthy adults were measured as controls.Results The neutrophil CD11b MFI in cord blood of vaginally delivered (VD) or in adult venous blood was much lower than that in cord blood of elective caesarian section (ECS) or in neonatal venous blood (all P0.05). There was no significant difference in CD11b MFI between VD cord blood and adult venous blood (P0.05).Conclusions 1.The mode of delivery affects neutrophil CD11b expression of neonates.2.CD11b expression on resting neutrophils of full term neonates is mature.
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