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Analysis of chromosome and its prognostic significance in childhood acute lymphoblastic leukemia

LU Aidong, ZHANG Leping, LIU Guilan, et al. Department of Pediatrics, People′s Hospital of Peking University, Beijing 100044, P.R. China  
Objective To analyze the chromosomal changes and its clinical significance in childhood acute lymphoblastic leukemia(ALL).Methods Bone marrow samples from 40 pretreated children with ALL were studied cytogenetically directly or after short term in vitro culture, and the clinical curative effect of the patients was observed.Results Chromosomal abnormalities were present in 70 % (28/40) cases, half of which were only numerical aberrations and 35.7 % cases were only structural aberrations. The complete remission rates in patients with normal and hyperdiploid karyotype were significantly higher than those with pseudodiploid and hypodiploid karyotype. The karyotype of hypodiploid or t(9;22) predicted worse prognosis.Conclusion Chromosomal analysis is significant for the prognosis and management in children with ALL.
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