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《Journal of Applied Clinical Pediatrics》 2009-01
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Continuous Administration of Adenosine by Peripheral Pathway Attenuate Myocardial Hypertrophy and Pulmonary Arterial Hypertension Induced by Hypoxia in Rats

FANG Xing,HUANG Xiu-lan,TAO Meng-jie,TAN Jian-xin(Department of Pediatrics,Affiliated Hospital of Guangdong Medical College,Zhanjiang 524023,Guangdong Province,China)  
Objective To explore if continuous administration of adenosine by peripheral pathway can attenuate myocardial hypertrophy and pulmonary arterial hypertension(PAH)caused by chronic hypoxia and analyze the dose-effect relationships between them.Methods Forty-eight Sprague-Dawley(SD)rats were randomly divided into 8 groups:the hypoxia group(n=6),the hypoxia ade-nosine-treated groups [n=18,adenosine was administrated with different doses 50,100,150 μg/(kg·min),the hypoxia adenosine-treated group A,B,C],the control group(n=6),the control adenosine-treated control groups [n=18,adenosine was administrated with different doses 50,100,150 μg/(kg·min),the control adenosine-treated control group A,B,C].On the 21st day of the experiment,the Medlab-U/4CS was used to determined the right ventricular systolic pressure(RVSP)and the mean pulmonary arterial pressure(mPAP)of each rat.The ratio of the weight of right ventricle/left ventricle and septum[RV/(LV+S)] and the ratio of the weight of right ventricle/body weight(RV/BW)were also calculated.The morphological changes in myocardium cells and pulmonary vascular structure were observed.SAS 8.0 software was used to analyze the data.Results Twenty-one days after hypoxia,RVSP,mPAP,RV/(LV+S),RV/BW in hypoxia groups were higher significantly than those in control group and hypoxia adenosine-treated groups(Pa0.01).In hypoxia adenosine-treated groups,with 3 different doses,a does of 150 μg/(kg·min)was the only one that could attenuate myocardial hypertrophy.In adenosine-treated control groups,among the 3 doses,50 μg/(kg·min)was the only one could attenuate the RVSP and mPAP(Pa0.05).Conclusions Continuous administration of adenosine by peripheral pathway can attenuate myocardial hypertrophy and PAH induced by chronic hypoxia in rats.There have some dose-effect relationships between them.J Appl Clin Pediatr,2009,24(1):38-40
【CateGory Index】: R96
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