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《Journal of Applied Clinical Pediatrics》 2009-01
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Expression and Significance of Caspase-3 and Survivin at Different Stages of Hemangioma in Children

LIU Hong1a,DANG Ya-mei1b,GUO Ying-fang1b,WANG Jin-sui1b,LIAN Shu-hua1a,QIAN Jiang2,QIAO Cheng-gang1a(1a.Department of Pediatric Surgery;1b.Department of Pathology,the People's Hospital of Gansu Province;2.Clinical Medical College of Lanzhou University,Lanzhou 730000,Gansu Province,China)  
Objective To investigate the expression and significance of Caspase-3 and Survivin at different stages of human hemangioma in children.Methods Fifty-five specimens of hemangioma tissue excised in operation and 8 normal skins removed in operation were harvested from People's Hospital of Gansu Province between Jan.2000 and Dec.2005.The pathologic diagnosis was divided into 3 groups according to Mulliken's standard under microscope:proliferated phase group(n=31),degenerated phase group(n=24),and control group(n=8).All these specimens were examined by immunohisto for Caspase-3 and Survivin expression.Results Caspase-3 positive rate in the proliferative phase and involuting phase were 35.5% and 79.2%,respectively.The positive rate in involuting phase was higher than that that in proliferative phase,the difference between the 2 groups was significant(P=0.045 9).A significant difference was not found between the proliferative phase and normal skin tissue(P=0.057 3).Survivin positive rate in the proliferating and involuting phase were 77.4% and 45.8%,respectively.The positive rate in proliferative phase was higher than that in involuting phase,the difference between the 2 groups was significant(P=0.008 5),the difference in involuting phase and normal skin tissue was not significant(P=0.059 3).Conclusions High level of Caspase-3 expression in vascular endothelial cells in involuting phase in contrast to that in proliferative phase,which indicates that Caspase-3 may play a positive role in the apoptosis of vascular endothelial cells.Survivin may inhibit the apoptosis of vascular endothelial cells in proliferative phase due to it's high expression.Caspase-3 and Surivivin involved in the hemangioma in the regulation of apoptosis.J Appl Clin Pediatr,2009,24(1):51-52
【Fund】: 甘肃省自然科学基金项目资助(3ZS061-A25-107)
【CateGory Index】: R739.5
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