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《Journal of Applied Clinical Pediatrics》 2009-02
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Changes of Humoral Immunity in Newborn Infants with Hypoxic-Ischemic Encephalopathy and Its Correlative Factors

YANG Mei1,LIN Li-xing1,WANG Jie2,ZHANG Zhi-ling1,YUAN Er-wei1(1.Department of Pediatrics,the First Hospital of Lanzhou University;2.Department of Pediatrics,Maternal and Child Health Hospital of Lanzhou,Lanzhou 730000,Gansu Province,China)  
Objective To explore the changes of humoral immunity in neonates with hypoxic-ischemic encephalopathy(HIE)and observe the influence of perinatal factors on humoral immune function.Methods Sixty-two neonates with HIE were enrolled and 30 healthy neonates were selected as control group.The percentages of CD19,CD25 of B lymphocyte were detected by Flow Cytometr.The levels of IgG,IgM,IgA and complement C3,C4 were detected by immune rate nephewlometry.The results were analyzed by SPSS 11.5 software.Results 1.The percentages of CD19+(17.93±3.10)%,CD19+CD25+(0.64±0.42)% and the levels of IgM(0.13±0.05)g/L,IgA(0.14±0.07)g/L and complement C3(0.62±0.12)g/L,C4(0.10±0.03)g/L in neonates with HIE were significantly lower than those in the healthy term neonates(Pa0.05,0.01).The level of IgG was no clinical differentiation in all neonates(P0.05).2.There were dignificant diffe-rences of the percentages of CD19+,CD19+CD25+ and the levels of IgM,IgA,complement C3,C4 among the different stages of HIE(Pa0.05),and those in neonates with severe HIE were significantly lower than those in mild to moderate(Pa0.05,0.01).3.Linear regression analysis showed that there was a positive correlation between CD19+,IgA,complement C4 and Apgar score,and there were correlation between IgG,IgM and amniotic fluid.There was higher IgA in the breastfeeding neonates.Positive correlations were found between IgG and birth weight.Conclusions HIE can lead to humoral immunity system changes,and there are correlation with the stages of HIE.Some perinatal factors such as feeding patterns,birth weight,amniotic fluid and Apgar score have effects on humoral immunity system of neonates with HIE.
【Fund】: 甘肃省自然科学基金资助项目(3ZS060-A25-086)
【CateGory Index】: R722.1
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