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《Journal of Applied Clinical Pediatrics》 2009-02
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Significance of Umbilical Cord Combined with Radial Arterial Blood Gas Analysis in Evaluating the Short-Term and Long-Term Prognosis in Newborn Infant with Anoxia

CHEN Hui-qing,ZHUANG Si-qi,LI Yi-juan,LIU Mei-na(Department of Neonatology,the First Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510080,Guangdong Province,China)  
Objective To explore the value of umbilical cord combined with radial arterial blood gas analysis at 1 hour after birth in evaluating the short-term and long-term prognosis of neonates with anoxia.Methods Five hundred and forty-one newborn infants admitted to our hospital from Oct.2004 to Nov.2006 were studied.Blood gas analysis of umbilical artery at birth and radial artery at 1 hour after birth were performed.According to the pH,they were divided into 4 groups:Umbilical arterial pH7.2 and radial arterial pH7.3 group(group 1);umbilical arterial pH≥7.2 and radial arterial pH7.3 group(group 2);umbilical arterial pH7.2 and radial arterial pH≥7.3 group(group 3);umbilical arterial pH≥7.2 and radial urterial pH≥7.3 group(group 4).One hundren and fifty-eight cases were followed up to evaluate their long-term development.By the scale of Child Development Center of China(CDCC),mental development index(MDI)and psychomotor development index(PDI)were checked in some cases of 1-2 years old.The results were analyzed by SPSS 13.0 software.Results Among group 1,group 2,group 3 and group 4,differences of organs dysfunction incidence had statistical significance(Pa0.01),and difference of long-term motor development abnormality had statistical significance(Pa0.05),but,difference of physical and intellec-tual development abnormality had no statistical significance.The children in group 1 had the most varieties of organs dysfunction(χ2=78.348 P0.01),and the highest incidence of motor development abnormality.Conclusions Combination of umbilical and arterial blood gas analysis may be predictive of multiple organs dysfunction.A low pH value of umbilical artery at birth and persistence or deterioration of pH after birth may be predictive of long-term motor development abnormality.Blood gas measurement shall be monitored if hypoxia and acidosis are identified.
【CateGory Index】: R722.1
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