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《Journal of Applied Clinical Pediatrics》 2009-02
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Therapeutic Effect of Oral Indomethacin for Patent Ductus Arteriosus in Full-Term Infants

DENG Li,ZHANG You-xiang,YU Li(Department of Pediatrics,the First People's Hospital of Guangzhou,Guangzhou 510180,Guangdong Province,China)  
Objective To explore therapeutic effect and side effect of oral indomethacin for treating patent ductus arteriosus(PDA)in full-term infants.Methods Forty-one full-term infants confirmed PDA by echocardiographically,who were admitted to the neonatal intensive care unit of our hospital from Jan.2004 to Dec.2007,were randomly divided into experimental group(21 cases)and control group(20 cases).Three oral doses of indomethacin [0.2 mg/(kg·time),at an interval of 12 hours] were administered in experimental group,while nothing in control group.Hepatorenal function and blood routine were measured in both groups in 2 days before and after treatment.Urine output and level of serum blood sugar were measured,and abdominal distension,vomiting,bloating,and bleeding were recorded during treatment.Color Doppler echocardiographic examination was performed,heart murmur was stethoscopied,and the rate of ductal closure was recorded at 5 to 7 days after treatment.The infants were followed up at out-patient department at 6 to 12 months after treatment,color Doppler echocardiographic examination was performed,and ductal closure condition was recorded.Results Hepatorenal function and blood routine were normal in experimental group in 2 days before and after treatment.Except that a little gastrointestinal bleeding occurred in one case of experimental group after the second dose of indomethacin,other adverse reactions were not observed during treatment.The ductus was closed in 16 infants in experimental group,the rate of ductal closure was 76.19%,while the ductus was closed naturally in 5 infants in control group,the rate of ductal closure was 25.0% at 5 to 7 days after treatment.There was significant difference in the rate of ductal closure between the experimental and control groups(χ2=10.74 P0.05).Followed up at out-patient department at 6 to 12 months after treatment,1 case of patent ductus was reopened in experimental group.Conclusion Oral indomethacin is safe and effective for the treatment of PDA in full-term infants,because of convenient usage and slight side effects.
【CateGory Index】: R722.1
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1 TU Qiao-wen,SHI Wen-jing,CHEN Chao (Department of Neonatology,Children's Hospital of Fudan Uiniversity,Shanghai 201102,China);Clinical applications of ibuprofen in preterm infants with patent ductus arteriosus[J];World Clinical Drugs;2009-09
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1 YANG Jie1,WANG Yi-biao2,ZHANG Kun2,WANG Yu-wei1,XIA Wei1,ZHAO Cui-fen1(1.Department of Pediatrics,Qilu Hospital,Jinan 250012,China;2.Department of Pediatrics,the Second Hospital of Shandong University,Jinan 250033,China);Clinical Effect and Follow-Up Analysis of Transcatheter Occlusion Therapy on Patent Ductus Arteriosus in Infants[J];Journal of Applied Clinical Pediatrics;2007-08
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1 Zhang Bo,Chen Ming Shanghai Eastern Hospital,Affiliated to Tongji University,Shanghai 200120 China;Evaluation of Indomethacin Repeated Treatment of Premature Infants with Recurrent Patent Ductus Arteriosus on Color Doppler Echocardiography[J];Chinese Journal of Ultrasound in Medicine;2007-11
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