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《Journal of Applied Clinical Pediatrics》 2009-09
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Study Progress on Pathogenesis of Idiopathic Thrombocytopenic Purpura

ZHANG Jun-hong,XU You-hua(Department of Hematology,Children′s Hospital of Chongqing Medical University,Chongqing 400014,China)  
Idiopathic thrombocytopenic purpura(ITP) as an autoimmune disease,is the most common clinical hemorrhagic disease.But,its pathogenesis is not completely clear yet.Low platelet count can easily repeate in chronic ITP patients,there are poor efficacy in refractory ITP patients,too.In recent years,a series of important progress on the pathogenesis of ITP had been made.In the humoral mechanism,there were significant progress on the emergence of autoantibodies;the theory on anomaly of the megakaryocyte quantity and quality caused by autoantibody were put forward.In the cellular mechanisms,the theory on reduction in the number of Tr cells,Co-stimulative signal and platelets directly dissolved by cytotoxicity T cells were put forward also.This review will be made to sum up the study progress on the pathogenesis of ITP.
【CateGory Index】: R725.5
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【Citations】
Chinese Journal Full-text Database 3 Hits
1 WU Run-hui (Department of Hematology Centre,Beijing Children′s Hospital Affiliated to Capital University of Medical Sciences,Beijing 100045,China);Advancement of Idiopathic Thrombocytopenic Purpura in Children[J];Journal of Applied Clinical Pediatrics;2007-03
2 LV Xue-wen,LIU Fang,WU Chang-lin (Department of Microbiology and Immunology, Guangdong Medical College,Zhanjiang 524023,China);Eexpression of Foxp3 and CD4~+CD_(25)~+ Regulation T Cells in Children with Acute Idiopathic Thrombocytopenic Purpura[J];Journal of Applied Clinical Pediatrics;2007-03
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【Co-citations】
Chinese Journal Full-text Database 4 Hits
1 WU Chang-lin1,XUE Jian-cheng1,ZHOU Xue-min1,LIU Fang2(1.Department of Transfusion Medicine,the Second People's Hospital of Shenzhen City,Shenzhen 518035,Guangdong Province,China;2.Department of Immunology,Guangdong Medical College,Zhanjiang 524023,Guangdong Province,China);Significance of Protein Kinase C Activity Detection in Children with Chronic Idiopathic Thrombocytopenic Purpura[J];Journal of Applied Clinical Pediatrics;2009-03
2 DENG Cai-yan,WANG Jun,WANG Xi-ge,FENG Jian-fei,ZHANG Yan-jie(Department of Pediatrics,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China);Expression of CD_(40) and CD_(40)L in Bone Marrow Mononuclear Cells in Children with Idiopathic Thrombocytopenic Purpura[J];Journal of Applied Clinical Pediatrics;2009-15
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4 ZHAO Xue-yun1,JIA Rui-ping2.(1.Baotou Medical College,Baotou 014040,China;2.Department of Hematology,Baotou Central Hospital,Baotou 014040,China);Research Progress of Idiopathic Thrombocytopenic Purpura[J];Medical Recapitulate;2009-15
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
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3 QIN Ping *, HOU Ming, SUN Jian-zhi, LU Lu, SHI Yan,ZHU Yuan-yuan,LI Li-zhen,ZHANG Mao-hong. *Department of Hematology, Qilu Hospital, Shandong University, Jinan 250012, China;Study on the direct MAIPA technique in the differential diagnosis of immune and non-immune thrombocytopenia[J];Chinese Journal of Hematology;2005-03
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