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《Journal of Applied Clinical Pediatrics》 2009-12
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Risk Factors for Intracranial Hemorrhage Caused by Late Vitamin K Deficiency

SONG Hong-yan,QIAN Su-yun,ZHANG Xi-pei(Department of Intensive Care Unit,Beijing Children's Hospital Affiliated to Capital Medical University,Beijing 100045,China)  
Objective To explore the risk factors for intracranial hemorrhage caused by late vitamin K deficiency bleeding(VKDB),in order to prevent and reduce the incidence of intracranial hemorrhage caused by late VKDB.Methods A retrospective analysis of the risk factors of late VKDB and intracranial hemorrhage was applied to 2 groups of patients in PICU and department of neurology of Beijing children's Hospital from Jan.2002 to Dec.2007.In group Ⅰ,there were 90 patients suffering from intracranial hemorrhage caused by late VKDB;while in group Ⅱ,there were 23 patients of late VKDB without intracranial hemorrhage.Within 12 hours of hospitalization,the following 9 items were checked:the cranial CT,blood calcium concentration,liver function,serum sodium,blood glucose,prothrombin time,partial thromboplastin time,fibrinogen concentration,and platelet.Ten possible relevant risk factors of gender,age,birth situation,feeding patterns,recent diarrhea,cytomegalovirus(CMV)infection,hypocalcemia,dysglycemia,hyponatremia,and abnormal liver function were analyzed by the method of non-conditional Logistic regression analysis.Results Statistically significant difference had been found in the 3 factors of hypocalcaemia,recent diarrhea,abnormal liver function(Pa0.01)between the group Ⅰ and group Ⅱ;meanwhile,OR values were 6.662,8.092,and 12.895,respectively.The risk of intracranial hemorrhage for children with late VKDB accompanied by hypocalcemia,abnormal liver function,and recent diarrhea were respectively 6.662,8.092,and 12.895 times higher than those of the late VKDB children with normal blood calcium,normal liver function,and no recent diarrhea.Conclusions Hypocalcemia,abnormal liver function,and recent diarrhea are the 3 high risk factors of intracranial hemorrhage caused by late VKDB,and the prevention of hypocalcemia can help prevent intracranial hemorrhage caused by late VKDB.
【CateGory Index】: R723
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【Citations】
Chinese Journal Full-text Database 3 Hits
1 SUN Yan-hong1,ZHANG Hui-feng2.(1 Department of Pediatric,Cangzhou Central Hospital,Cangzhou,Hebei 061001,China;2 Department of Pediatric,the Second Hospital of Hebei Medicd University,Shijiazhuang,Hebei 050000,China);Study on the status of vitamin K in infants and their mothers with late vitamin K deficiency bleeding[J];Chinese Journal of Child Health Care;2007-04
2 SONG Hong-yan,QIAN Su-yun(Department of Intensive Care Unit,Beijing Children′s Hospital Affiliated to Capital Medical University,Beijing 100045,China);Research Progress of Introcranial Hemorrhage Caused by Late Form Vitamin K Deficiency[J];Journal of Applied Clinical Pediatrics;2008-18
3 ZHANG Xiao-li,ZHANG Xin-hua,SUN Da-quan.Department of Pediatric,Shanxi Medical University,Taiyuan 030001,China.;The Interference and Prognosis on Hypocalcemia in Newborn with Hypoxic-ischemic Encephalopathy[J];Chinese Journal of Natural Medicine;2007-03
【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 ZHOU Jin-ping1,LIU Li-xiang1,DAI Yu-liang1,MIAO Gui-jie1,ZHANG Hui-feng2.(1 The People's Hospital of Tangshan,Tangshan,Hebei 063001,China;2 Department of Pediatrics,the Second Hospital of Hebei Medical University,Shijiazhuang,Hebei 050000,China);Quantitative analysis on the PIVKA-Ⅱ concentration of plasma in children treated with the cephalosporin[J];Chinese Journal of Child Health Care;2007-06
2 Shaoguan Railway Hospital Pediatric Shaoguan 512023,China;The Investigation of Risk Factors for Neonatal Hypocalcemia[J];China Foreign Medical Treatment;2009-28
【Secondary Citations】
Chinese Journal Full-text Database 9 Hits
1 GUO Janghong Mother and Child Health Institute of Yangchun City, Guangdong Prouince, Yangchun 529600, China;Late intracranial hemorrhage by vitamin K deficiency: an analysis of 56 cases[J];Chinese Journal of Neuromedicine;2003-04
2 KANG Quan-li, ZHANG Ji-fang, JIN Yong-jian, CAI San-chuan, MA Geng-ping, YANG Xiao-ming, WANG Lu, LI Wei. Department of Neurosurgery, Beijing Shunyi District Hospital, Beijing 101300, China;Minimally invasive surgery for intracranial hematoma caused by delayed vitamin K deficiency in infants[J];Chinese Journal of Neuromedicine;2005-11
3 He Shaoqiang. Department of Paediatrics, 150 Hospital in PLA,Luoyang 471031;On the Changes of the Calcium Pump Activity in Erythrocytic Membrane and Endo-exo-erytherocytic Calcium concentration Before and After Supplementary Calcium in Neona-tal Hypoxic Ischemic Encephalopath(HIE)[J];Chinese Journal of Child Health Care;1997-01
4 ZHANG Hui feng 1,WANG Wei ping 2.(1 Department of Pediatrics,the Second Hospital of Hebei Medical University,Shijiazhuang, Hebei 050000,China; 2 Children's Hospital, Fudan University, Shanghai, 200032,China);Analysis of 3 970 cases of late vitamin K deficiency bleeding in infancy[J];Chinese Journal of Child Health Care;2004-01
5 ZHANG Hui-feng , PANG Bao-dong, DAI Xiu-hua , LIU Shuang-lin , WANG Ai-qin , TIAN Xiu-qiao , LI Gen-shan ,MARTIN J Shearer. (Department of Pediatrics, Second Hospital, Hebei Medical University, Shijiazhuang, Hebei 050000, China; Department of Pediatrics, Tangshan Institute for Maternal and Child Care, Tangshan, Hebei 063000, China; Vitamin K Research & Diagnostic Laboratories, the Haemophilia Reference Centre, St Thomas' Hospital, London, England);Oral Orakay to newborns improving their vitamin K deficiency status.[J];Chinese Journal of Child Health Care;2005-01
6 GUO WenXiang REN LiXin * LI YanZhi;The preventive and curative effects of Nimodipine to hypoxic-ischemic brain damage in the neonatal rats[J];Journal of Brain and Nervous Diseases;2002-02
7 HUANG Ai-rong,HE Shi-jun.Pediatric Department,Yuying Children's Hospital Affliated to Wenzhou Medical College,Wenzhou 325027,China.;Analysis of risk factors in intracranial hemorrhage of late vitamin K deficiency[J];Chinese Pediatric Emergency Medicine;2006-03
8 Zhang Huifeng,Wang Xiaokang,Li Wei et al The second Hospital,Hebei University of Medical;Vitamin K status in pregnant women and their newborns in high incidence area of late Vitamin K deficiency bleeding[J];Maternal and Child Health Care of China;2001-10
9 Nong Shaohan;Li Zhuosuan;Feng Zekang;et al. (Department of Pediatrics,BuangdongProvincial People's Hospital,Guangzhou510080.);CHANGES OF INTRA- AND EXTRA-CEL-LULAR CALCIUM CONCENTRATIONS IN BRAIN CELLS AND ERYTHROCYTES PRI-OR TO AND POST CALCIUM SUPPLEMEN-TATION IN NEONATAL RAT HYPOXIC IS-CHEMIC ENCEPHALOPATHY MODEL[J];Chinexe Journal of Pediatrics;1995-06
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