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《Journal of Applied Clinical Pediatrics》 2009-12
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Risk Factors for Intracranial Hemorrhage Caused by Late Vitamin K Deficiency

SONG Hong-yan,QIAN Su-yun,ZHANG Xi-pei(Department of Intensive Care Unit,Beijing Children's Hospital Affiliated to Capital Medical University,Beijing 100045,China)  
Objective To explore the risk factors for intracranial hemorrhage caused by late vitamin K deficiency bleeding(VKDB),in order to prevent and reduce the incidence of intracranial hemorrhage caused by late VKDB.Methods A retrospective analysis of the risk factors of late VKDB and intracranial hemorrhage was applied to 2 groups of patients in PICU and department of neurology of Beijing children's Hospital from Jan.2002 to Dec.2007.In group Ⅰ,there were 90 patients suffering from intracranial hemorrhage caused by late VKDB;while in group Ⅱ,there were 23 patients of late VKDB without intracranial hemorrhage.Within 12 hours of hospitalization,the following 9 items were checked:the cranial CT,blood calcium concentration,liver function,serum sodium,blood glucose,prothrombin time,partial thromboplastin time,fibrinogen concentration,and platelet.Ten possible relevant risk factors of gender,age,birth situation,feeding patterns,recent diarrhea,cytomegalovirus(CMV)infection,hypocalcemia,dysglycemia,hyponatremia,and abnormal liver function were analyzed by the method of non-conditional Logistic regression analysis.Results Statistically significant difference had been found in the 3 factors of hypocalcaemia,recent diarrhea,abnormal liver function(Pa0.01)between the group Ⅰ and group Ⅱ;meanwhile,OR values were 6.662,8.092,and 12.895,respectively.The risk of intracranial hemorrhage for children with late VKDB accompanied by hypocalcemia,abnormal liver function,and recent diarrhea were respectively 6.662,8.092,and 12.895 times higher than those of the late VKDB children with normal blood calcium,normal liver function,and no recent diarrhea.Conclusions Hypocalcemia,abnormal liver function,and recent diarrhea are the 3 high risk factors of intracranial hemorrhage caused by late VKDB,and the prevention of hypocalcemia can help prevent intracranial hemorrhage caused by late VKDB.
【CateGory Index】: R723
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