Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Applied Clinical Pediatrics》 2009-15
Add to Favorite Get Latest Update

Relationship between CD4~+CD_(25)~(high)Foxp~3+Treg Lymphocytes and CD5~+B Lymphocytes in Peripheral Blood in Children with Severe Aplastic Anemia

YU Hui,BAI Yan,QIU Yi-ning,LIU Qin,XIAO Yan,ZHOU Dong-feng,JIN Run-ming(Department of Pediatrics,Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430022,Hubei Province,China)  
Objective To investigate the quantitative changes of CD4+CD25highFoxp3+Treg lymphocytes and CD5+B lymphocytes in peripheral blood of children with severe aplastic anemia (SAA) and analyze the relationship between them. Methods Quantities of CD4+CD25highFoxp3+Treg lymphocytes and CD5+B lymphocytes in peripheral blood of 36 children with SAA (SAA group) and 60 healthy children (healthy group) were assayed by flow cytometry.The correlation between the quantitative changes of CD4+CD25highFoxp3+Treg lymphocytes and CD5+B lymphocytes was analyzed.Results The quantity of CD4+CD25highFoxp3+Treg lymphocytes was significantly lower in SAA group[(1.56±0.77)%] than that in healthy group[(3.73±0.93)%](P0.01),while the quantity of CD5+B lymphocytes in SAA group was significantly higher than that in healthy group[(21.47±6.89)% vs (12.21±6.18)%,P0.01].The quantity of CD4+CD25highFoxp3+Treg lymphocytes showed negative correlation with CD5+B lymphocytes(P0.01).After effective immuno suppressive therapy(IST) treatment,the quantity of CD4+CD25highFoxp3+Treg lymphocytes [(2.62±0.75)%]ascended significantly compared with pretherapy (P0.05),but descended significantly compared with healthy group (P0.05).CD5+B lymphocytes [(11.75±8.12)%]descended significantly compared with pretherapy(P0.01).Conclusions CD4+CD25highFoxp3+Treg lymphocytes in peripheral blood of children with SAA significantly decreased and CD5+B lymphocytes increased,which may be related with the onset of the disease.The quantitative decrease of CD4+CD25highFoxp3+Treg lymphocytes may be related with the increasing of CD5+B lymphocytes.
【CateGory Index】: R725.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 3 Hits
1 QIU Yi-Ning, BAI Yan, YU Hui, ZHOU Dong-Feng, ZHANG Zhi-Quan, XIAO Yan, JIN Run-Ming. Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong Science and Technology University, Wuhan 430022,China;Therapeutic effects of a combination of high-dose immunoglobulin and cyclosporine A in children with aplastic anemia[J];Chinese Journal of Contemporary Pediatrics;2009-01
2 SHEN Er-xia WU Chang-you(Department of Immunology, School of Basic Medicine , Sun Yat-sen University, Guangzhou 510080, China);CD4~+CD25~+ Regulatory T Cells Suppress B Cell-mediated Immune Response[J];International Journal of Immunology;2006-04
3 BAI Yan,YU Hui,ZHANG Zhi-quan,LIU Qin,XIAO Yan,ZHOU Dong-feng,FEI Hong-bao,JIN Run-ming(Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,P.R.China);The changes of CD_4~+CD_(25)~(High)Foxp3~+Treg cell and the Foxp3 gene expression in childhoodacute idiopathic thrombocytopenic purpura before and after treatment[J];Shandong Medical Journal;2008-37
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Guo Ninghong,Shi Qingzhi,Hua Jianyuan(Department of Hematology,the Second Affiliated Hospital,Nanchang University,Nanchang 330006,China);Regulatory T cells and Th17 cells in idiopathic thrombocytopenic purpura[J];Chongqing Medicine;2011-12
2 ZHANG Li-jun, LI Bo, ZHONG Li, WANG Xun, LI Jian-song, ZHUANG Jun-han, YE Zhi-zhong. Department of Rheumatology, Xiangmihu Branch of Shenzhen Futian People′s Hospital, Guangdong 518040, China;Study on B lymphocyte subsets in periphral blood of patients with systemic lupus erythematosus and its relationship with humour immunity[J];Chinese Journal of Rheumatology;2005-01
3 ZHAO Fen-Ying,XU Xiao-Jun,SONG Hua,YANG Shi-Long,TANG Yong-Min.Division of Hematology-oncology,Children′s Hospital of Zhejiang University School of Medicine,Hangzhou 310003,China;Effectiveness of immunosuppressive therapy for childhood aplastic anemia and its predictive factors[J];Chinese Journal of Contemporary Pediatrics;2012-08
4 QIN Wei , CHEN Guang-fu , GAO Hong-ying, CHEN Juan-juan (Shenzhen Second People′s Hospital, Guangdong, Shenzhen 518035, China);Evaluation of combined anti-thymocyte globulin and cyclosporin A therapy in the treatment of severe aplastic anemia in children[J];Journal of Tropical Medicine;2013-03
5 DAI Ping;YU Bei;the Fourth People's Hospital of Zigong;;The observation of the efficacy and safety of cyclosporin A in aplastic anemia[J];Sichuan Medical Journal;2013-09
6 WANG Hao 1, HE Yuan 2, ZHOU Li 2, TAN Qinghua 3 (1Department of Gastroenterology, the Fifth Affiliated Hospital of Guangzhou Medical College, Guangzhou 510700, China; 2Department of Gastroenterology, 3Digestive Endoscopic Center, the Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China.);The Changes of T Lymphocyte Subsets in Local Tissue of Gastric Mucosal Electrocision in Rats[J];Clinical Medical & Engineering;2011-10
7 YE Zhi-zhong*, ZHANG Li-jun, WANG Xun, LI Bo, ZHONG Li, LI Jian-song, ZHUANG Jun-han, Gao Jian-hua. *Department of Lupus Erythematosus The Xiangmihu Rheumatology Hospital, the Branch of Shenzhen Futian People′s Hospital, Shenzhen 518040, China;Correlation of peripheral B-lymphocyte subsets′change with the disease activity in systemic lupus erythematosus cases[J];Chinese Remedies & Clinics;2004-06
8 SHEN Erxia 1,2 , WU Changyou 1 (1. Department of Immunology, Zhongshan School of Medicine, State Ministry of Education Key Laboratory of Tropical Disease Control, Sun Yat-sen University, Guangzhou 510080, China; 2.Department of Microbiology and Immunology, Guangzhou Medical College, Guangzhou 510182, China.);Depletion of CD4~+ CD25~+ T cells could lead to increased OVA specific humoral response of mice[J];Journal of Molecular Diagnostics and Therapy;2011-04
9 LIU Wei.(Department of PICU,Tianjin Children′s Hospital,Tianjin 300060,China);Practical Value of CD_4~+CD_(25)~+ Treg in Pediatric Clinic[J];Medical Recapitulate;2009-19
10 SI Xu-wei, ZHAN Qian-gang, ZHU Qi-qian, GUAN Li-li, YU Zhong-ming, LOU Da-jun, JIN Hua-wei, MA Jing-bo, YE Fei. Shaoxing People′s Hospital,Shaoxing, Zhejiang 312000;Alteration in peripheral blood CD_5~+B cells is associated with disease activity in Graves′ disease[J];Chinese Journal of Endocrinology and Metabolism;2006-02
【Co-references】
Chinese Journal Full-text Database 3 Hits
1 Department of Clinical Immunology,XiJing Hospital,Fourth Military Medical University(Xi'an 710032) Yang Xichao Wu Zhenbiao Zhu Ping et al;Expression of BAFF/BAFF-R in labial salivary glands/peripheral blood from pSS patients and its significance[J];Shaanxi Medical Journal;2011-07
2 LU Chun-wei1,TONG Hai-xia2,LU Mei-yan3 (1.Section of Health Testing,College of Public Health,China Medical University,Shenyang 110001,China;2.Laboratory of Hematology,Shengjing Hospital,China Medical University,Shenyang 110022,China;3.Department of Dental Technology,College of Stomatology,Dalian Medical University,Dalian 116044,China);Detection of Lymphocyte Subsets and Regulatory T cells in Peripheral Blood of Patients with Aplastic Anemia and Its Clinical Significance[J];Journal of China Medical University;2010-10
3 HE Guang-sheng ZHOU Ling WU De-pei SUN Ai-ning MIAO Miao WANG Xiu-li CHANG Wei-rong ZHU Zi-ling JIN Zheng-ming QIU Hui-ying TANG Xiao-wen FU Zheng-zheng HAN Yue MA Xiao CHEN Su-ning WU Xiao-jin First Affiliated Hospital of Soochow University,Jiangsu Insititute of Hematology,Suzhou 215006,China;Role of CD28/CTLA-4 costimulators in immune pathophysiology of aplastic anemia[J];Chinese Journal of Hematology;2007-09
【Secondary Citations】
Chinese Journal Full-text Database 5 Hits
1 Guo-Cheng ZHANG , Guo-Ping SU, Xin SUN, Dong-Liang XU, Cai-Ping CHEN, Xue-Qing TANG , Rim LI Department of Pediatrics , Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China;Sequence Analysis and Genetic Variation of NS Gene of Human Parvovirus B19 Isolated from Chinese Children with Acute Aplastic Anemia[J];The Chinese Journal of Contemporary Pediatrics;2003-01
2 Xiao-Tian XIE, Yao-Ping WANG, Wei SHI. Department of Pediatric Hematology and Oncology, Tongji Hospital, Tongji University, Shanghai 200065, China;Effects of combined immunosupressive therapy on severe aplastic anemia and refractory aplastic anemia in children[J];The Chinese Journal of Contemporary Pediatrics;2004-06
3 HUANG Yong-Lan, HUANG Shao-Liang, HUANG Ke, CAI Yun.Department of Pediatrics, Second Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510120, China;Biological characteristics of bone marrow-derived mesenchymal stem cells and their relationship with immunosuppressive therapy in children with aplastic anemia[J];Chinese Journal of Contemporary Pediatrics;2008-01
4 Sheng-Jun Wang1,2*, Hua-Xi Xu1, Sheng-Li Yang2(1Department of Immunology, School of Medical Technology, Jiangsu University, Zhenjiang 212001, China;2Life Science Institute, Jiangsu University, Zhenjiang 212013, China);CD4~+CD25~+ Regulatory T Cells[J];Chinese Journal of Coll Biology;2005-01
5 LU Xue-Hong, YU Chun-Lei, LI Yi.Department of Immunology, School of Basic Medical Sciences, Jilin University, Changchun 130021, Jilin, China;The changes of CD4~+CD25~+ T cells and expression of Foxp3 mRNA in peripheral blood mononuclear cell from patients with systemic lupus erythematosus[J];Chinese Journal of Gerontology;2007-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved