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《Journal of Applied Clinical Pediatrics》 2009-15
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Relationship between CD4~+CD_(25)~(high)Foxp~3+Treg Lymphocytes and CD5~+B Lymphocytes in Peripheral Blood in Children with Severe Aplastic Anemia

YU Hui,BAI Yan,QIU Yi-ning,LIU Qin,XIAO Yan,ZHOU Dong-feng,JIN Run-ming(Department of Pediatrics,Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430022,Hubei Province,China)  
Objective To investigate the quantitative changes of CD4+CD25highFoxp3+Treg lymphocytes and CD5+B lymphocytes in peripheral blood of children with severe aplastic anemia (SAA) and analyze the relationship between them. Methods Quantities of CD4+CD25highFoxp3+Treg lymphocytes and CD5+B lymphocytes in peripheral blood of 36 children with SAA (SAA group) and 60 healthy children (healthy group) were assayed by flow cytometry.The correlation between the quantitative changes of CD4+CD25highFoxp3+Treg lymphocytes and CD5+B lymphocytes was analyzed.Results The quantity of CD4+CD25highFoxp3+Treg lymphocytes was significantly lower in SAA group[(1.56±0.77)%] than that in healthy group[(3.73±0.93)%](P0.01),while the quantity of CD5+B lymphocytes in SAA group was significantly higher than that in healthy group[(21.47±6.89)% vs (12.21±6.18)%,P0.01].The quantity of CD4+CD25highFoxp3+Treg lymphocytes showed negative correlation with CD5+B lymphocytes(P0.01).After effective immuno suppressive therapy(IST) treatment,the quantity of CD4+CD25highFoxp3+Treg lymphocytes [(2.62±0.75)%]ascended significantly compared with pretherapy (P0.05),but descended significantly compared with healthy group (P0.05).CD5+B lymphocytes [(11.75±8.12)%]descended significantly compared with pretherapy(P0.01).Conclusions CD4+CD25highFoxp3+Treg lymphocytes in peripheral blood of children with SAA significantly decreased and CD5+B lymphocytes increased,which may be related with the onset of the disease.The quantitative decrease of CD4+CD25highFoxp3+Treg lymphocytes may be related with the increasing of CD5+B lymphocytes.
【CateGory Index】: R725.5
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