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《Journal of Applied Clinical Pediatrics》 2009-15
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Clinical Effect of Yisui Shengxue Granule on β-Thalassemia Major

ZHENG Liu-ming1,ZHANG Xin-hua2,WU Zhi-kui3,WANG Wen-quan1,ZHOU Tian-hong2,WEI Zhao-hua1,LI Xing-yang1,HUANG Pei-sheng1,WANG Li2,ZHOU Ya-li2(1.Department of Traditional Chinese Medicine,Chongzuo People's Hospital,Chongzuo 532200,Guangxi Zhuang Autonomous Region,China;2.Department of Hematology,the 303 Hospital of People's Liberation Army,Nanning 530021,Guangxi Chuang Autonomous Region,China;3.Department of Molecular Biology,Guang an'men Hospital,China Academy of Traditional Chinese Medicine,Beijing 100053,China)  
Objective To investigate the clinical effect of Yisui Shengxue Granule on β-thalassemia major.Methods Yisui Shengxue Granule was used to treat 44 cases with β-thalassemia major and 22 cases with β-thalassemia major combined with hemoglobin E.Aged from 2 to 16 years old;45 boys and 21 girls.Yisui Shengxue Granule,which was 10 gram per package,was used 1 package each time.To children younger than 6 years old,it was used twice per day; to children older than 6 years old,it was taken 3 packages each day.The level of hemoglobin (Hb),red blood cell (RBC),reticulocytes(Ret),fetal hemoglobin(HbF) were measured before and after treatment.Results The therapy was effective in 37 out of 44 cases with β-thalassemia major and 21 out of 22 cases with β-thalassemia combined with hemoglobin E.The levels of Hb,RBC,Ret and HbF post-therapy significantly increased compared with pre-therapy[β-thalassemia major:Hb(g/L) 46.40±10.68 vs 55.73±13.87,RBC(×1012 L-1) 2.31±0.55 vs 2.85±0.80,Ret(%) 6.56±3.73 vs 9.30±5.47,HbF(%) 49.55±24.81 vs 64.57±26.11;β-thalassemia combined with hemogobin E:Hb(g/L) 50.18±9.03 vs 64.36±11.12,RBC(×1012 L-1) 2.77±0.45 vs 3.51±0.54,Ret(%) 10.05±7.70 vs 14.55±9.93,HbF(%) 25.77±9.50 vs 32.05±12.56](Pa0.01).Conclusions Yisui Shengxue Granule is very effective to β-thalassemia major.It can increase the Hb concentration,and alleviate therefore alleviate symptoms resulting from anemia.
【Fund】: 国家自然科学基金项目资助(90409003);; 广西自然科学基金项目资助(桂科基0447104);; 广西卫生厅科学基金项目资助(Z2008009)
【CateGory Index】: R272
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