Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Applied Clinical Pediatrics》 2009-15
Add to Favorite Get Latest Update

Effects of Coincident Infection on Treatment Response and Coronary Artery Lesion Outcome in Children with Kawasaki Disease

CUI Yan-qin,YU Ming-hua,HUANG Ping,ZHANG Li(Department of Cardiology,Guangzhou Women and Children's Medical Center,Guangzhou 510120,Guangdong Province,China)  
Objective To explore the effects of coincident infection on treatment response and coronary artery lesion (CAL) outcome in children with Kawasaki disease(KD).Methods A retrospective study of 141 children diagnosed on KD between Jul.2005 and Dec.2006 were performed.Standardized clinical assessments,laboratory examinations microbiology test results plus treatment regimens were reviewed.CAL were visualized by using echocardiography.Infectious agents positive (INF+) and negative (INF-) groups were identified,and clinical assessments,laboratory and treatment data were analyzed.Results 1.Concurrent infections:41%(58/141) of children had one of above confirmed infection at KD diagnosis.2.Treatment response:the presence of infection did not alter the response to treatment with intravenous immunoglobulin (IVIG),with resolution of fever within 72 h in 85% (120/141) children after 1 dose of IVIG (2 g/kg) together with aspirin administration regardless of present or absent infection.3.CAL outcome:in total,56.0% (79/141) of children developed CAL at the time of diagnosis,involving dilatation (91.1%,72/79 cases) and aneurysm (8.9%,7/79 cases),and no giant aneurysm was found.Most CAL were recovered within 1 year after treatment.Incidence of aneurysm in INF+ group was significantly higher than that in INF-group (P=0.019).Conclusions Coincident infection would not affect on the clinical assessment,laboratory test results and treatment response to IVIG in children with KD,but would result in higher risk of serious CAL.Therefore,children with infection at diagnosis on KD will not only accept active treatment in acute phase,but also insist on convalescent care and follow-up visit.
【CateGory Index】: R725.4
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 3 Hits
1 PI Guan_huan,YANG Xi_qiang,WEI Yu_shu,LU Yu (Department of Pediatrics, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan,637007,China);Detection of various virus antibody IgM levels of the serum in the acute phase of KD[J];Journal of North Sichuan Medical College;2001-04
2 CHEN Xin-min(Department of Pediatrics,Fuzhou General Hospital of Nanjing Command,Fuzhou 350025,China);Current Situation of Diagnosis and Treatment of Kawasaki Disease[J];Journal of Applied Clinical Pediatrics;2008-09
3 ZHU Guo-hong1,BAO Xing-er1,YE Fang1,CHEN Zhi-min1,CHEN Li-qin2(1.Department of Respiratory;2.Medical Laboratory,Children's Hospital Affiliated to Medical College of Zhejiang University,Hangzhou 310003,China);Relationship between Chlamydia Pneumoniae Infection and Changes of Coronary Artery in Children[J];Journal of Applied Clinical Pediatrics;2007-16
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 SUN Yu-Ping, WANG Wen-Di, WANG Jin-Ju, WANG Li-Yan. Qingdao Children's Hospital, Qingdao, Shangdong 266011,China;Levels of serum heart-type fatty acid-binding protein and its clinical significance in children with Kawasaki disease[J];Chinese Journal of Contemporary Pediatrics;2008-02
2 Fan Ying, Wu Changxue, Gao Yuli Dept of Ultrasound, The Affiliated Hospital of Luzhou Medical College, Luzhou 610041, China;Character and significance of mitral annulus motion in patients with kawasaki disease[J];Journal of Ultrasound in Clinical Medicine;2007-01
3 PENG Xiao-wei, LI Xian-wen, YAN Ji-yong, LIU Fei-si, LIU Qing-hua (Jiangxi Children's Hospital, Nanchang 330006, China);Value and method of color Doppler echocardiography in detecting total anomalous pulmonary venous connection[J];Journal of China Clinic Medical Imaging;2006-09
4 GAO Hong,MIN Jie-qing,TIAN Xiu-ling,MA Yue-ming,FAN Wei,YI Xin(Department of Diagnostic Technology,Kun Ming Children's Hospital,Kunming 650034,Yunnan,China);Diagnosis of coronary artery lesions and long-term follow-up in patients with Kawasaki disease by echocardiogram[J];Journal of Clinical Pediatrics;2008-11
5 Xing Haihua,Huang Meirong,Nie Yunzhang et al.Department of Cardiology,Shanghai Children's Medical Center,Medical School of Shanghai Traffic University.Shanghai ,200127,China;Analysis of electrocardiographic characteristics of atrial isomerism[J];Journal of Clinical Electrocardiology;2008-01
6 FANG Hui,ZHU Jianfang,XIONG Hui,XIAO Juhua,DAI Nina Department of Ultrasound,the First Affiliated Hospital,Medical College of Nanchang University,Nanchang 330006,China;The study of color kinesis in the diagnosis of wall motion abnromaliies of Kawasaki disease[J];Journal of Ultrasound in Clinical Medicine;2009-03
7 ZHANG Xiao-jie, ZHANG Yu-qi, CHEN Sun, ZHANG Zhi-fang, SHEN Rong, HUANG Mei-rong (Department of Pediatric Cardiology, Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200127, China);Noninvasive preoperative diagnosis in children with atrioventricular septal defects[J];Journal of Clinical Pediatrics;2009-05
8 Qus shunmei, Wu yurong, Hong wenjing, et al. Department of Cardiology, Shanghai Children's Medical Center, Medical School of Shanghai Jiao Tong University, Shanghai, 200127, China;The electrocardiogram analysis on the anomalous origin of the left coronary artery from the pulmonary artery[J];Journal of Clinical Electrocardiology;2009-02
9 WU Da-wei,WANG Xi-ming,WU Le-bin,CHENG Zhao-ping,CHAO Bao-ting,YU Fu-hua(Shandong Medical Image Institute,Ji'nan 250021,China);The Application of 64-slice Spiral CT Coronary Artery Angiography in Children[J];Journal of Practical Radiology;2008-01
10 YAO Yi,SHEN Qun-shan,ZHANG Gang-cheng,LIU Mei,CHENG Yu-mei(Wuhan Yazhou Heart Hospital,Wuhan,Hubei 430022,China);Right Heart Catheterization Analysis of 18 Patients with Atrial Septal Defect Associated Severe Pulmonary Hypertension[J];Journal of Practical Medical Techniques;2008-27
【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 WU Wei~1,LIU Yude~1,LI Rong~1,WU Hui~1,WANG Song~1,HUANG Yanshou~1,OU Ming~2(1.The First Affiliated Hospital,Guangzhou University of TCM,Guangzhou 510405,China;2.Guangzhou University of TCM,Guangzhou 510405,China);Influence of Chlamydia Pneumoniae Infection on Atherosclerotic Plaque Area and Therapeutic Effect of Baicalin[J];Journal of Guangzhou University of Traditional Chinese Medicine;2006-04
2 ZHANG Wei,LI Qiu,ZHAO Xiao-dong,TANG Xue-mei,WANG Xiao-gang,WANG Mo,WU Dao-qi,OU Qian,YANG Xi-qiang.Division of Nephrology and Immunology,the Affiliated Children′s Hospital,Chongqing University of Medical Sciences,Chongqing 400014,China;Clinical analysis of 942 cases of Kawasaki disease[J];Chinese Journal of Pediatrics;2006-05
3 CHENG Yan-li~(1),LIU Lu-shan~(1,2),WANG Gui-xue~(2),YANG Yong-zong~(1)(1.Institute of Cardiovascular Diseases,Nanhua University,Hengyang 421001;2.College of Bioengineering,Chongqing University,Chongqing 400044,China);Chlamydia pneumoniae infection inducing vascular smooth muscle cell change in function and morphology[J];International Journal of Pathology and Clinical Medicine;2006-05
4 YU Hai-jie1, QI Guo-xian2 (1.Department of Internal Medicine, The Second Affiliated Hospital, China Medical University, Shenyang 110004, China; 2.Department of Cardiology, The First Affiliated Hospital);Clinical study of the association of chlamydia pneumoniae infection with acute myocardial infarction[J];Journal of China Medical University;2006-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved