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《Journal of Applied Clinical Pediatrics》 2009-15
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Immunomodulatory Effect of Thymopentin on Post-Chemotherapeutic Cancer in Children

WANG Ling-zhen,SUN Li-rong,PANG Xiu-ying(Department of Pediatric Hematology,the Affiliated Hospital of Medical College,Qingdao University,Qingdao 266003,Shandong Province,China)  
Objective To evaluate the immunologic function,and safety of thymopentin(TP-5) on post-chemotherapeutic cancer in children.Methods Forty malignant tumor children were randomly divided into treatment group and control group.TP-5 was administered to treatment group for 6 months(30 kg,10 mg per time,once per week;≥30 kg,10 mg per time,twice per week).No immunomedulatory the-rapy was administered to control group.Cell-mediated immunologic function(CD3,CD4+,CD8+,CD4+/CD8+),natural killer (NK) cells function(CD56),humoral immunologic function(IgG,IgM,IgA)were measured after 3 months and 6 months.Liver function,renal function,blood and electrocardiogram (ECG) were tested regularly.Results 1.There was no difference in the immunologic function between the treatment group and the control group before therapy(Pa0.05);2.The cell-mediated immunologic function(CD3,CD4+,CD8+,CD4+/CD8+)was not different between 2 groups after 3 months(Pa0.05),and NK cells function(CD56),humoral immunologic function(IgG,IgM,IgA)were significantly elevated after TP-5 administration for 3 months(Pa0.05);3.After TP-5 administration of 6 months,all the immunologic functions were significantly improved (Pa0.01);4.There were great differences in cellular immunity,NK cells function,and humoral immunologic function between the treatment after 3 months and after 6 months with TP-5 administration;5.After 3-month therapy,the infection rate in the treatment group was 15%,and the period of infection control lasted for 3-5 days(mean 3.8 d),while in the control group,the infection rate was 65%(13/20 cases),and the period of infection control lasted for 5-10 days(mean 6.5 d); the infection rate in the control group was much higher than that in the treatment group(χ2=9.30 P0.01),and the time for control infection was longer in the control group than that in the treatment group(t=4.40 P0.01);6.During the treatment of 6 months,only 1 child had an ache in the injective site,and the abnormality of liver function,renal function and ECG changes were not observed.Conclusions TP-5 may significantly improve the cell-immunologic function and lower the rate of the infection in post-chemotherapeutic cancer children.It's effective and safe in the clinical application.
【CateGory Index】: R730.5
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