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《Journal of Applied Clinical Pediatrics》 2009-15
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Study Progress of Hematopioetic Stem Cell Transplantation Therapy on Acute Leukemia in Children

TANG Xiang-feng,LUAN Zuo(Department of Pediatrics,Navy General Hospital of Chinese People's Liberation Army,Beijing 100037,China)  
Hematopoietic stem cell transplantation(HSCT) is one of the measures therapy on acute leukemia in children.Very-high-risk children with acute lymphocytic leukemia (ALL),such as Philadelphia chromosome-positive(Ph+),T cell immunophenotype,achieved the first complete remission(CR1),and then receive allogeneic HSCT(allo-HSCT).The transplantation group had significantly improved disease-free survival(DFS)and overall survival(OS) compared with chemotherapy group. ALL children in the second complete remission(CR2) were recommended to receive allo-HSCT,especially early-relapse group. All children in the third complete remission (CR3) were recommended to receive an allo-HSCT,and reduce replapse rate through inducing graft versus leukemia.Total body irradiation-based conditioning regimens in children with ALL has advantage over chemotherapy conditioning regimens.Children with acute myeloblastic leukemia (AML) achieved CR1 and then undergo all-HSCT.This group had significantly improved DFS and OS compared with chemotherapy group.The children with relapsed AML,if having suitable donor,were recommended to receive allo-HSCT. The children with AML who underwent transplantation relapse,and can receive the second transplantation.There was no advantage in children patients with AML using TBI-based conditioning regimens.Conditioning regimens consisted of high-dose cytarabine,in combination with granulocyte colony-stimulating factor has advantage,and improve DFS. Unrelated umbilical cord blood has emerged as a potential option.Compared with unrelated bone marrow transplantation,there was no different in DFS and relapse.For the extent,it is one of the donor hematopoietic stem cell sources.
【CateGory Index】: R733.7
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1 TAO Hong-fang1,HU Qun1,FANG Jian-lin2,LIU Ai-guo1,LIU Shuang-you1,ZHANG Liu-qing1,HU Ying1(1.Department of Pediatrics,Tongji Hospital;2.Department of Radiology,Union Hospital,Affiiated to Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430030,China);Expressions of Silencer of Death Domains and p65 in Children with Acute Lymphoblastic Leukemia and Its Relationship with Chemotherapeutic Drugs[J];Journal of Applied Clinical Pediatrics;2008-03
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1 FENG Lin1,QIAO Shu-kai2,XU Shi-rong2(1.Department of Pediatrics;2.Department of Hematology,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,Hebei Province,China);Clinical Prognostic Value of Expression of DNA Methyltransferases Genes in Children with Acute Leukemia[J];Journal of Applied Clinical Pediatrics;2009-03
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