Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Applied Clinical Pediatrics》 2009-18
Add to Favorite Get Latest Update

Influence of Heme Oxygenase-1 Inhibitor Protoporphyrin Ⅸ Zinc on Hyperoxic Lung Injury in Preterm Rats

QUAN Yu-feng1,ZHENG Ming-ci2,ZHANG Hua1,ZHANG Pei-lin1,ZHANG Hong1(1.Department of Neonatology;2.Perinatology of Laboratory,the Affiliated Hospital of Guilin Medical College,Guilin 541001,Guangxi Zhuang Autonomous Region,China)  
Objective To explore the effect of protoporphyrin Ⅸ zinc(Znpp) on hyperoxic lung injury in preterm rats.Methods Three-day-old preterm SD rats were randomly assigned to room air control group(group Ⅰ)hyperoxia control group(oxygen≥900 mL/L)(group Ⅱ),room air plus Znpp group(group Ⅲ),hyperoxia plus Znpp group(group Ⅳ).Group Ⅲ and group Ⅳ were injected intraperitoneally with ZnPP 45 μmol/kg each day.After the third day and the 7th day of exposure,the activity of heme oxygenase-1(HO-1) and the percent of carboxyhemoglobin(HbCO) in the lungs,the lung wet weight /dry weight ratio(W/D),tumor necrosis factor-α(TNF-α),total protein and malondialdehyde(MDA) in bronchoalveolar lavage fluid were determined and lung histophathological changes were examined in all groups.Results On the third day,compared with group Ⅰ the activity of HO-1 and the percent of HbCO in the lungs,W/D,TNF-α,total protein and MDA,all greatly rised in group Ⅱ(Pa0.05,0.01,respectively),and the activity of HO-1 and the percent of HbCO in the lungs,W/D,TNF-α,MDA in group Ⅳ significantly dropped compared with those in group Ⅱ(Pa0.01,0.05,respectively);On the 7th day,the activity of HO-1 and the percent of HbCO in the lungs,TNF-α,total protein,MDA in group Ⅱ all went up markedly compared with those in group Ⅰ(Pa0.01),and the activity of HO-1,the percent of HbCO in the lungs,TNF-α,total protein,MDA in group Ⅳ all significantly reduced compared with those in group Ⅱ(Pa0.01,0.05,respectively).Group Ⅱ showed acute lung injury characterized by the presence of hyperaemia,red cell extravasation,and inflammatory infiltration after 3 days,the pulmonary pathologic changes alleviated in group Ⅳcompared with that in group Ⅱ.After 7 days of exposure,Group Ⅱ showed subacute inflammatory response,pulmonary fibrosis,alveolar stunting,while the changes were relieved in group Ⅳ compared with that in group Ⅱ.Conclusions HO-1 could be associated with the hyperoxia-induced lung injury of premature rats.Znpp may play a protective role against hyperoxia-induced pulmonary damage by inhibiting the activity of HO-1.
【Fund】: 广西科技厅科技攻关基金项目资助(0472002-35)
【CateGory Index】: R722.6
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 5 Hits
1 SHAO Qin1,RONG Xiao-ping2,JIANG Lian2,MENG Fan-hang2,GUO Xiu-xia3(1.Department of Pediatrics,Xingtai People's Hospital,Xingtai 054000,China;2.Department of Pediatrics,the Fourth Hospital Affiliated to Hebei Medical University,Shijiazhuang 050011,China;3.Department of Pediatrics,Shijiazhuang Obstrics and Gynecology Hospital,Shi-jiazhuang 050000,China);Significance of Measuring Heme Oxygenase-1 in Umbilical Blood of Full Term Small for Gestational Age[J];Journal of Applied Clinical Pediatrics;2008-02
2 ZHOU Xiao-guang1,LIU Xiu-xiang2,LIU Ren-hong3,XIAO Xin4,CHANG Li-wen1(1.Department of Pediatrics,Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430030,China;2.Department of Neonatology,the First Affiliated Hospital of Jinan University,Guangzhou 510632,China;3.Department of Pediatrics,Shajing People's Hospital of Shenzhen Bao'an District,Shenzhen 518104,China;4.Department of Neonatology,the Sixth Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China);Relationship between Lung Ultrastructure and Oxidative Stress Reaction of Newborn Premature Rats Exposed on Hyperxia[J];Journal of Applied Clinical Pediatrics;2008-12
3 XU Wei,FU Jian-hua,XUE Xin-dong(Department of Pediatrics,Shengjing Hospital Affiliated to China Medical University,Shenyang 110004,Liaoning Province,China);Dynamic Expression of HoxB5 in Lung Tissue of Neonatal Rats with Hyperoxia-Induced Chronic Lung Disease and Its Significance[J];Journal of Applied Clinical Pediatrics;2009-04
4 QUAN Yu-feng,ZHENG Ming-ci,ZHANG Hua,DENG Yi,ZHANG Guo-feng,ZHANG Pei-lin.Department of Pediatrics,Affiliated Hospital of Guilin Medical College,Guilin 541001,China;The effect of gingkgo injection on the expression of heme oxygenase-1 in the lungs of hyperoxia-induced preterm rats[J];Chinese Journal of Neonatology;2008-04
5 YU Jian-bo, YAO Shang-long, YUAN Shi-ying (Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430022, China);Role of heme oxygenase-endogenous carbon monoxide in the regulation of cardiac function during lipopolysaccharide shock in rats[J];Chinese Journal of Pathophysiology;2006-01
【Co-citations】
Chinese Journal Full-text Database 9 Hits
1 WANG Yang1,XU He-jing2,WANG Wan-tie1,CHEN Ying-ying3,SHEN Yue-liang3,DU You-ai2 (1.Dept.of Pathophysiology;2.Dept.of Physiology,Wenzhou Medical College,Wenzhou 325035;3.Dept.of Physiology,School of Medicine,Zhejiang University,Hangzhou 310006,China);Involvement of COX-2 in antagonism to heme oxygenase-1 on cardioprotection from anoxia/reoxygenation induced injury in rats[J];Basic & Clinical Medicine;2007-07
2 DU Hui (P.E. Department of Yancheng Normal College, Yancheng Jiangsu 224002);Exercise and HO/CO System[J];Liaoning Sport Science and Technology;2007-02
3 QUAN Yu-feng1,ZHENG Ming-ci2,ZHANG Hua1,DENG Yi1,ZHANG Hong1(1.Department of Neonatology,the Affiliated Hospital of Guilin Medical College;2.Laboratory of Perinatology Affiliated to Guilin Medical College,Guilin 541001,Guangxi Zhuang Autonomous Region,China);Changes of Expression and Activity of Heme Oxygenase-1 in Lung Tissue of Hyperoxia-Induced Preterm Rats[J];Journal of Applied Clinical Pediatrics;2009-06
4 LI Si-tao1,HAO Hu1,XIAO Xin1,XIA Yuan-sheng2,LIANG Jian-hua2(1.Department of Pediatrics,the Sixth Hospital Affiliated to Sun Yat-Sen University,Guangzhou 510655,Guangdong Province,China;2.Department of Cardiovascular Surgery,Guangzhou Children′s Hospital,Guangzhou 510120,Guangdong Province,China);Change of Levels of Plasma 8-Iso-Prostaglandin F_(2α) during Cardiopulmonary Bypass in Infants with Conge-nital Heart Disease and Therapeutic Effect of N-Acetylcysteine[J];Journal of Applied Clinical Pediatrics;2009-11
5 SHAO Xiao-song,LU Chao,ZHOU Guo-ping,HU Yu-hua(Department of Pediatrics,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,Jiangsu Province,China);Effects of Oxidative Stress on Expression of Cell Cycle and Apoptosis-Regulatory Protein-1 in Lung Epithe-lial Type Ⅱ Cells[J];Journal of Applied Clinical Pediatrics;2009-16
6 ZENG Sai-zhen1,WU Xiao-chuan2,ZHONG Li-li1,ZHANG Bing1(1.Department of Pediatrics,the People′s Hospital of Hunan Province,Changsha 410005,Hunan Province,China;2.Department of Pediatrics,the Second Xiangya Hospital,Central South University,Changsha 410011,Hunan Province,China);Prolonged Hyperoxia Exposure Induced Pathological Changes and Apoptosis of Neonatal Rats Kidney[J];Journal of Applied Clinical Pediatrics;2009-17
7 HUANG Xin-li, WEI Peng, ZHOU Xiao-hong, LING Yi-ling (Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017,China.;Role of heme oxygenase in cholecystokinin octopeptide ameliorating acute lung injury induced by lipopolysaccharide[J];Chinese Journal of Pathophysiology;2007-12
8 DUAN Chun,ZHU Yan,HU Yun-yue,LONG Feng.(Shenzhen Maternity and Child Health Hospital,Southern Medical University,Shenzhen,518028,China);High-sensitivity C-reactive protein level in Cord Blood and its clinical significance in small-for-gestational-age neonates.[J];Chinese Journal of Birth Health & Heredity;2009-06
9 YANG Fan1,2,SHUAI Ming-qi1,YANG Jie1,ZHU Li2,SHEN Yue-liang2,CHEN Ying-ying2(1National Education Base for Basic Medical Sciences,2Department of Physiology,Zhejiang University School of Medicine,Hangzhou 310058,China. );Curcumin ameliorates high glucose-induced dysfunction of vasoconstriction via heme oxygenase-1 and GC pathway[J];Chinese Journal of Pathophysiology;2010-01
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Li-Ling QIAN, Li-Wen CHANG, Qian-Shen ZHANG, Zhi-Hui RONG Department of Pediatrics , Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.;Lung Injury of Preterm Rats Induced by Prolonged Exposure to High Oxygen Concentration of 85%[J];Chinese Journal of Contemporary Pediatrics;2003-02
2 ZHOU Jie, HUANG Yinping. (Department of Obstetrics and Gynecology, First Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000, China);Expression of heme oxygenase in the placenta and trophoblast cells of preeclampsia and their changes after intervention of DHAP[J];Chinese Journal of Clinical Obstetrics and Gynecology;2006-06
3 WANG Hong-xia,HUANG Wei-yi,WEI Zong-de.Department of Cardiology,The Affiliated Hospital,Luzhou Medical University,Luzhou 646000,China;The study of heme oxygenase-1 and cardiovascular disease[J];International Journal of Internal Medicine;2007-01
4 JIANG Xiao-yan,GAO Xin-yuan,KUANG Hong-yu(Department of Endocrinology,The First Clinical College,Harbin Medical University,Harbin 150001,China);The protective effect of ginaton biloba extract on apoptosis of ratinal nerve cells of diabetic rats[J];Journal of Harbin Medical University;2007-02
5 ZHANG Xin,GUO Zai-chen Department of Pediatrics,the First Hospital of Peking University , Beijing 100034, P.R. China;Hyperoxic regulation of lung heme oxygenase-1 in neonatal rats[J];Journal of Applied Clinical Pediatrics;2003-10
6 PENG Qiong- ling,CHANG Li- wen,LU Hong-yan,CAI Cheng,JIANG Na,LI Wen-bin(Department of Pediatrics,Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430030,China);Temporal Expression of Reduced Nicotinamide Adenine Dinucleotide Dehydrogenase in Lung of Premature Rats with Hyperoxia-Induced Lung Injury[J];Journal of Applied Clinical Pediatrics;2007-14
7 YUE Xiao-hong,FU Jian-hua,XUE Xin-dong(Department of Pediatrics,the Shengjing Hospital Affiliated to China Medical University,Shenyang 110004,China);Apoptosis of Alveolar Epithelial Cell and Its Mechanism in Premature Rat with Hyperoxia-Induced Chronic Lung Disease[J];Journal of Applied Clinical Pediatrics;2008-02
8 Quan Yufeng, Chang liwen , Ma Liya ,etal. Pediatric department of Tongji Hospital of Huazhong Sci - Tech University, Wuhan;QUANTATIVE ANALYSIS OF TGF - P, IN DIFFERENT KIND OF CELL IN LUNG TISSUES OF HYPEROXIA - INDUCED PULMONARY FIBROSIS IN PRE- TERM RATS[J];The Journal of Neonatology;2003-01
9 Yumei;Yan Chaoying;Gao Yuxian Department of pediatrics, The First Clinical Hospital Jilin University, Chang chun 130021, China;A STUDY ON PROTECTIVE EFFECT OF EGB ON NEURONAL APOPTOSIS ASSOCIATED WITH CEREBRAL ISCHEMIA INJURY IN NEONATAL RATS Li[J];The Journal of Neonatology;2004-03
10 ZHOU Xiao-guang, LIU Xiu-xiang, LIU Ren-hong, XIAO Xin, XIONG Ai-hua. Department of Neonatology, The Second Affiliated Hospital of Guangzhou Medical College, Guangzhou 510260, China.;The inhibiting effect of N-acetylcysteine on pulmonary fibrosis caused by hyperoxia induced lung injury in newborn premature rats[J];Chinese Journal of Neonatology;2007-01
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved