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《Journal of Applied Clinical Pediatrics》 2009-18
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Clinical Intervention on Vascular Endothelial Injury in Children with Kawasaki Disease

PI Guang-huan1,TIAN Xiao-bing2,WANG Mei1,WU Chun1,HUANG Yue1,SUN Qun-ying1,HE Yun1(1.Department of Pediatrics,the Affiliated Hospital of North Sichuan Medical College;2.Department of Epidemiology,North Sichuan Medical College,Nanchong 637000,Sichuan Province,China)  
Objective To investigate the relationship between coronary artery lesions and circulation endothelial cells(CEC) in perip-heral blood and level of blood plasma von Willebrand factor(vWF) in Kawasaki disease(KD) patients,and influence of immunoglobulin intravenous(IVIG) and low molecular heparin treatment on them.Methods There were 45 children with KD in the study.According to with or without coronary artery lesions they were divided into 2 groups.The first group had 30 children without coronary artery lesions,the other had 15 children with coronary artery lesions.Twenty healthy children were served as healthy control group.All patients with KD were treated with IVIG,2 g/kg in a single infusion on days 5 to 10 of illness and begun treatment of low molecular heparin in the first 4 days after IVIG therapy,100 IU/kg,one time every 12 hours,hypodermic,continuous use for 7 days.CEC were isolated from peripheral blood with immunomagnetic Dynabeads and were counted by using microscopy.Level of blood plasma vWF was determined by double antibody sandwich enzyme linked immunosorbent assay.Results CEC count in peripheral blood in coronary artery lesions group was higher than that in without coronary artery lesions group,and higher in both groups than that in healthy control group(F=151.7 P0.001).Level of blood plasma vWF in the coronary artery lesions group was higher than that in without coronary artery lesions group and higher in both groups than that in healthy control group(F=16.2 P0.001).There were significant differences of CEC quantity and level of blood plasma vWF before and after IVIG treatment in coronary artery lesions group(t=9.31,4.43 Pa0.001) or without coronary artery lesions group(t=8.92 P0.001,t=2.97 P0.01)].There were significant differences also of CEC quantity and level of blood plasma vWF before and after low molecular heparin treatment in coronary artery lesions group(t=3.45 P0.001,t=2.28 P0.05) or without coronary artery lesions group(t=3.51 P0.001,t=2.61 P0.01).Conclusions There is obvious blood vessel endothelium injury in KD and endothelium injury of patients with coronary artery lesions is even worse.Treatment with IVIG and low molecular heparin appeared to significantly improve endothelium injury.
【Fund】: 四川省卫生厅课题资助[川卫办发(2006)437号]
【CateGory Index】: R725.4
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【Citations】
Chinese Journal Full-text Database 4 Hits
1 CHEN Yao,WANG Yi,LI Yan,SUN Shu-zhen,WANG Yu-lin(Shanddong Prorincial Hospital,Jinan 250021,P.R.China);A clinical study on vascular endothelial dysfunction and histological impairment in simple obese children[J];Shandong Medical Journal;2007-35
2 LI Jun,YANG Shi-wei,CAO Li-ming,YU Yi,WANG Feng-ming,QIN Yu-ming,WANG Da-wei(Department of Emergency,Nanjing Children's Hospital Affiliated to Nanjing Medical University,Nanjing 210008,China);Clinical Signifiance of Changes of Serum Soluble Vascular Cell Adhesion Molecule-1 and Tumor Necrosis Factor-α in Children with Kawasaki Disease[J];Journal of Applied Clinical Pediatrics;2007-09
3 HU Yu-wei,ZHOU Chuan-xin,CHEN Li-hua(Department of Pediatrics,the Fifth Affiliated Hospital of Sun Yat-Sen University,Zhuhai 519000,China);Significance of Platelet Parameters in Children with Kawasaki Disease in Diagnosis and Prognosis[J];Journal of Applied Clinical Pediatrics;2007-13
4 DU Zhong-dong(Department of Cardiology,Beijing Children′s Hospital Affiliated to Capital Medical University,Beijing 100045,China);Anticoagulat Therapy in Acute and Long-Term of Kawasaki Disease[J];Journal of Applied Clinical Pediatrics;2008-13
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 HUANG Hua-zhen, YE Zhong-lu, LIANG Ren. (Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, Guangdong, P. R. China);Changes and clinical significance of platelet parameters in children with Kawasaki disease[J];China Tropical Medicine;2008-05
2 LIAO Ruosha, DU Shujuan(Dept.of Pediatrics,the Second Affiliated Hospital,Guangzhou University of TCM,Guangzhou 510120 Guangdong,China);Effect of Heat-clearing and Blood-activating Herbs on Platelet Parameters in Children with Kawasaki Disease[J];Journal of Guangzhou University of Traditional Chinese Medicine;2008-06
3 WEI Hong-ping,WU Min,ZHU Hong-feng(Department of Pediatrics,the Affiliated Hospital of Luzhou Medical College,Luzhou 646000,China);Research Progress of Predisposing Gene in Kawasaki Disease[J];Journal of Applied Clinical Pediatrics;2008-09
4 SUN Xing-zhen(Department of Pediatrics,Huai′an First Affiliated Hospital of Nanjing Medical University, Huai′an 223300,Jiangsu Province, China);Relationship between Serum C-Reaction Protein,Tumor Necrosis Factor-α and Changes of Myocardiac Enzymology,Coronary Artery Lesions in Children with Kawasaki Disease[J];Journal of Applied Clinical Pediatrics;2008-21
5 NI Jun-xue,FU Hong-min,MA Yan,WAN Jian;Changes of Platelet Membrane Glycoproteins-140 and Platelet Parameters in Children with Sepsis[J];Journal of Applied Clinical Pediatrics;2009-06
6 ZHOU Min1,LI Xiao-hui1,LI Xiao-jing1,XU Ming1,XU You-hua2,YANG Mo3(1.Department of Hematology,Chengdu Children′s Hospital,Chengchu 610017,Sichuan Province,China;2.Department of Hematology,Children′s Hospital of Chongqing Medical University,Chongqing 400014,China;3.Department of Pediatrics & Adolescent Medicine,Li Ka Shing Faculty of Medicine,Hong Kong University,Hong Kong,China);Changes of Serum Soluble CD_(40) Ligand in Rabbits with Immune Vasculitis and Effect of Drug Treatment[J];Journal of Applied Clinical Pediatrics;2009-09
7 TIAN Xin,HE Xiang-ling,FANG Yi-bing,ZOU Run-ying,LIU Shan-shan (Department of Pediatrics,Hunan Province People's Hospital,the First Affiliated Hospital of Hunan Normal University,Changsha 410005,Hunan Province,China);Changes of Thrombopoietin and Platelet Parameter in Children with Kawasaki Disease and Their Correlation[J];Journal of Applied Clinical Pediatrics;2009-13
8 WANG Feng-ming,LI Jun,ZHAO Nai-zheng,QIN Yu-ming,ZHU Shan-liang (Department of Cardiology,Nanjing Children's Hospital Affiliated to Nanjing Medical University,Nanjing 210008,Jiangsu Province,China);Relationship between Endothelial Nitric Oxide Synthase Gene Polymorphisms and Susceptivity of Coronary Artery Lesions in Children with Kawasaki Disease[J];Journal of Applied Clinical Pediatrics;2009-13
9 YAO Genhong,LIU Zhihong,CHEN Huiping,ZHENG Chunxia,ZENG Caihong,LI Leishi Research Institute of Nephrology,Jinling Hospital,Nanjing University Clinical School of Medicine,Nanjing 210002,China;Evaluation of renal vascular lesions using circulating endothelial cells in patients with lupus nephritis[J];Chinese Journal of Nephrology,Dialysis & Transplantation;2007-01
10 YANG Ming-yu,QIN Jing-ting,YANG Fang-yuan,WANG Xin,ZHANG Ming(Department of Pediatrics,the Affiliated Hospital of Guilin Medical College,Guilin 541001,Guangxi Zhuang Antonomous Region,China);Changes and Clinical Significance of D-Dimer,Fibrinogen and C-Reaction Protein in Kawasaki Disease[J];Journal of Applied Clinical Pediatrics;2009-19
【Secondary Citations】
Chinese Journal Full-text Database 9 Hits
1 JIANG Li-xue 1,SHI Gui-ying 2,SHI Xue-geng 2,XU Yi-ping(1. Department of Respiratory Diseases,Renji Hospital,Shanghai Second Medical University, Shanghai 200001;2. Department of Biophysics,Shanghai Second Medical University,Shanghai 200025);Study on Change of the CD4~+ and CD8~+T Cell Populations in Peripheral Circulation Producing IFN-γ and IL-4 in Neonates,Children and Adults[J];Shanghai J.of Immunology;2002-01
2 ZHANG Yong-lan1,DU Zhong-dong1,ZHAO Di2,DU Jun-bao3,LU Shan4,YI Jing-mei5,HOU An-cun6,ZHOU Zhong-shu7,DING Guo-fang8,LIN Yao1,LIU Chong1;Beijing Kawasaki Disease Cooperative Research Group (1.Department of Cardiology,Beijing Children's Hospital Affiliated to Capital University of Medical Sciences,Beijing 100045,China;2.Department of Cardiology,Capital Institute of Pediatrics,Beijing 100020,China;3.Department of Pediatrics,the First Hospital of Peking University,Beijing 100034,China;4.Department of Pediatrics,the Third Hospital of Peking University,Beijing 100083,China;5.Department of Pedia-trics,People's Liberation Army General Hospital,Beijing 100853,China;6.Department of Pediatrics,Beijing Friendship Hospital Affiliated to Capital Medical University,Beijing 100050,China;7.Department of Pediatrics,Sina-Japanese Friendship Hospital,Beijing 100029,China;8.Department of Pediatrics,Peking Union Hospital Affiliated to Peking Union Medical University,Beijing 100730,China);Epidemiologic Study on Children with Kawasaki Disease in Beijing from 2000 to 2004[J];Journal of Applied Clinical Pediatrics;2007-01
3 Tang Zhang-hua,Dong Wen-bin, Huang Rong-zhong (Department of Pediatrics, Affiliated Hospital of Luzhou Medical College, Sichuan, 646000,China);Changes and clinical significance of platelet parametar in children with kawasaki disease[J];Medical Journal of West China;2004-02
4 WEI Yu-jie,LIU Hui-liang,JING Li-min,FANG Dan-jun:General Hospital of Chinese People's Armed Police Forces,Beijing,100039,China;Correlation among serum sVCAM-1,vWF levels and severity of coronary atherosclerosis[J];Chinese Journal of Cardiovascular Rehabilitation Medicine;2006-05
5 Lu Minli Department of Ultrasound,Xiangshan First Hospital,Xiangshan,Zhejiang 315700 China;Echocardiographic Diagnosis of Coronary Artery Lesions in Kawasaki Disease[J];Chinese Journal of Ultrasound in Medicine;2006-09
6 Xu Liyun et al. Xu Shujuan, Linyi Medical College;THE DYNAMIC CHANGES OF PLATELET PARAMETES IN ASPHCITIC NEONATE AND THEIR VALUES.[J];China Child Blood;2002-05
7 Pu Xiuhong~1,An Tao~1,Li Jing~2,Guo Xiaoqing~1,Qiu Meng~1,Li qian~1(1.Department of Pediatrics,309~(th) clinical Division,General Hospital of the People's Liberation Army,Beijing,100091 China);The Clinical Significance of Platelet Parameter Changes in Kawasaki Disease[J];Chinese Journal of Medicine;2006-06
8 Ding Zongyi. Beijing Institute of Pediatrics, Beijing Children′s Hospital, Beijing 100045;Childhood obesity in China[J];Chinexe Journal of Pediatrics;1998-07
9 LIANG Chun-jie(The People' s Hospital,Zhanjiang,Guangdong524037,P.R.China);Change of platelet parameter and its significance in children with Kawasaki disease[J];China Journal of Modern Medicine;2004-22
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