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《Journal of Applied Clinical Pediatrics》 2009-18
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Therapeutic Effects of Interferon-α and Polyresistin on Measles in Children

ZHAO Hui-xin1,JIA Li-ying1,DENG Li1,DENG Jie2(1.Department of Infection,the Children′s Hospital Affiliated to Capital Pediatric Institute;2.Virus Laboratory,Capital Pediatric Institute,Beijing 100020,China)  
Objective To explore the therapeutic effects and safety of interferon-α(IFN-α) and polyresistin on measles in children.Methods One hundred and twelve children with measles were selected,measles′ antibody of all patients were positive,from department of infection of the children′s hospital affiliated to capital pediatric institute since Jan.2000 to Jun.2002 and since Jan.2007 to Feb.2008.They were 62 male,50 female,aged 0-3 years were 70 cases(62.5%),3-6 years were 24 cases(21.4%),6-10 years were 11 cases(9.8%),10-15 years were 7 cases(6.3%),they were randomly divided into treatment group and contol group.The treatment group with 60 patients were given INF-α and polyresistin,age 3 years,given IFN-α 100 000 U per day;and Polyresistin 2.5 mg per time,3 times every day.Age3 years,given IFN-α 200 000 U per day;and polyresistin 5 mg per time,3 times every day,the course of therapy were 5 days.The control group was given traditional Chinese medicine at the same time.Results After therapy,in treatment group,53 cases(88.3%) of children′s cooling time were lower than 5 days,47 cases(78.3%) of children′s rash subsided time were lower than 6 days,48 cases(75%) of children′s Catarrhal symptoms disappeared time were lower than 5 days,and the rate of complications′ occurrence were 15 cases(18.3%).In control group,28 cases(53.8%) of children′s cooling time were lower than 5 days,14 cases(26.9%) of children′s rash subsided time were lower than 6 days,28 cases(53.8%) of children′s Catarrhal symptoms disappeared time were lower than 5 days,and the rate of complications′ occurrence were 37 cases(71.5%),there were significant differences between both groups(Pa0.05,0.01).And there was no apparent toxicity in treatment group.Conclusions The treatment for measles in children with IFN-α and polyresistin had significant effect,they were safety and reliable to popularize.
【CateGory Index】: R725.1
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