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《Journal of Applied Clinical Pediatrics》 2009-21
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Clinical Significance and Expression of Serum Matrix Metalloproteinase-9 in Children with Kawasaki Disease

ZENG Jun,CHEN Zhao-hong(Department of Pediatrics,Guangzhou Women and Children's Medical Center,Guangzhou 510120,Guangdong Province,China)  
Objective To investigate the clinical significance of matrix metalloproteinase-9(MMP-9)in the pathogenesis of Kawasaki disease(KD)and its complications of coronary arterial lesions(CAL).Methods Twenty-three inpatients with KD were admitted in hospital from Jan.2005 to Dec.2006,whose venous blood samples were obtained during the acute and convalescent stage respectively,and CAL was detected with 2-Dechocardiography.Twenty-seven venous blood samples(12 febrile children and 15 normal physical examination children)were collected as healthy controls.Serum levels of MMP-9 were measured by enzyme-linked immunoadsorbent assay(ELISA).According to the results of echocardiography,children were divided into 2 groups:with CAL group(n=13)and without CAL group(n=10).Results During the acute stage,serum MMP-9 levels were significantly higher in KD than those in controls(Pa0.01).Furthermore,MMP-9 levels were significantly higher in CAL group than those in without CAL group(P0.01).During the convalescent stage serum MMP-9 levels decreased significantly in KD group,and in without CAL group the data were similar to those of controls,but in with CAL group,serum MMP-9 levels were still significantly higher than those in without CAL group(P0.01).The levels of MMP-9 in febrile children were significantly higher than those in healthy controls(P0.05).Conclusions Over-expression of MMP-9 in the acute phase of KD may be involved in the formation of CAL and pathogenesis of KD.
【Fund】: 广州市医药卫生科技项目资助(2005-YB-058)
【CateGory Index】: R725.4
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