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《Journal of Applied Clinical Pediatrics》 2009-21
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Therapeutic Efficacy Analysis of Kawasaki Disease with Different Ages and Different Therapy

LI Shu-juan,WANG Hui-shen,LI Yun-quan,CHEN Guo-zhen,QIN You-zhen,LI Ge-li(Department of Cardiology Pediatrics,the First Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510080,Guangdong Province,China)  
Objective To approach the short-term therapeutic efficacy of Kawasaki disease(KD)by different therapy,and the efficacy in different age.Methods Retrospective analyze 68 children in the First Affiliated Hospital of Sun Yat-Sen University from Jan.2006 to May 2008.First,68 children were divided into 2 groups according to different administration of intravenous immuno-glublin(IVIG),2 g/kg for 1 d or 1 g/(kg·d)for 2 days,respectively,then compare the recovery time of clinical symptom,the peripheral white blood cells(WBC),C-reactive protein(CRP),erythrocyte sedimentation rate(ESR)and the recovery of coronary artery with each other by SPSS 12.0 software.Then,according to different ages the 68 children were divided into 3 groups:3 years,3-5 years,5 years,to compare the above indexes again during the groups also by SPSS 12.0 software.Results With different IVIG use,there were no statistical difference between the 2 groups in the recovery time including fever,conjunctival congestion,chilo-rhagades,rash,acro-swell,lymphadenectasis,and the recovery of WBC,CRP,ESR after 2 weeks' therapy,the coronary artery.While to children of different ages,there were also no statistical difference in the recovery of above clinical indexes,WBC and CRP,but in the descending rate of ESR and the recovery of coronary artery,5 years group was worse than those in the other 2 groups.Conclusions The IVIG administration in KD,2 g/kg used for 1 d or 1 g/(kg·d)for 2 d,makes no statistical different efficacy.There's different efficacy in children with different ages,and the short-term efficacy tends to be better in children younger than 5 years.
【CateGory Index】: R725.4
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