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《Journal of Applied Clinical Pediatrics》 2009-21
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Analysis of Lymhocyte Subsets and Humoral Immunity Condition in Children with Kawasaki Disease Complicated with Coronary Artery Dilatation

WANG Wei,LAI Jian-ming,LIU Zhe-wei(Molecular Immunology Laboratory,Capital Institute of Pediatrics,Beijing 100020,China)  
Objective To explore the clinical diagnosis,medication,curative effect,and prognosis of lymhocyte subsets and humoral immunity in children with Kawasaki disease(KD)complicated with coronary artery dilatation.Methods One hundred and seventy-one children(age of 4 months to 9 years)from Jun.2000 to Dec.2007 with KD in Capital Institute of Pediatrics were taken as research objective,65 healthy children(age of 5 months to 7 years)were taken as controls,the difference of the level variation of lymhocyte subsets and humoral immunity was detected and analyzed between them.The flow cytometry and scattering turbidimetry method were used to detect the numbers of T cell subsets [CD3+,CD3+CD4+,CD3+CD8+,CD19+,natural killer(NK)cell] and levels of immune globulin(IgG,IgA,IgM)of the peripheral blood of 171 patients,compare them with those of the control group,and compare them between patients with and without coronary artery dilatation.Results Compared with control group,in the acute period of KD the levels of CD3+,CD3+CD4+ decreased significantly(t=0.01,0.02 Pa0.05),while the levels of CD3+CD8+,CD4+/CD8+,CD19+,IgG,IgA,IgM increase significantly(t=0.00 Pa0.05),level of NK cell didn't have significant change(t=0.46 P0.05);of all the 171 children patient,53 cases were coronary artery expansion patients.Compared with non-expansion patients,levels of CD4+/CD8+,CD3+CD8+,IgG of coronary artery expansion patients were significant different and had statistical difference(t=0.02,0.04,0.03 Pa0.05).Conclusions Patients in the acute period of KD have functional disorder in modulating and humoral immunity,ratios of CD4+ and CD8+ decreased;cases of children patients that have high levels of CD3+CD8+ and IgG have a more incidence of coronary artery expansion and poor prognosis.
【CateGory Index】: R725.4
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