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《Journal of Applied Clinical Pediatrics》 2009-21
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Analysis of Lymhocyte Subsets and Humoral Immunity Condition in Children with Kawasaki Disease Complicated with Coronary Artery Dilatation

WANG Wei,LAI Jian-ming,LIU Zhe-wei(Molecular Immunology Laboratory,Capital Institute of Pediatrics,Beijing 100020,China)  
Objective To explore the clinical diagnosis,medication,curative effect,and prognosis of lymhocyte subsets and humoral immunity in children with Kawasaki disease(KD)complicated with coronary artery dilatation.Methods One hundred and seventy-one children(age of 4 months to 9 years)from Jun.2000 to Dec.2007 with KD in Capital Institute of Pediatrics were taken as research objective,65 healthy children(age of 5 months to 7 years)were taken as controls,the difference of the level variation of lymhocyte subsets and humoral immunity was detected and analyzed between them.The flow cytometry and scattering turbidimetry method were used to detect the numbers of T cell subsets [CD3+,CD3+CD4+,CD3+CD8+,CD19+,natural killer(NK)cell] and levels of immune globulin(IgG,IgA,IgM)of the peripheral blood of 171 patients,compare them with those of the control group,and compare them between patients with and without coronary artery dilatation.Results Compared with control group,in the acute period of KD the levels of CD3+,CD3+CD4+ decreased significantly(t=0.01,0.02 Pa0.05),while the levels of CD3+CD8+,CD4+/CD8+,CD19+,IgG,IgA,IgM increase significantly(t=0.00 Pa0.05),level of NK cell didn't have significant change(t=0.46 P0.05);of all the 171 children patient,53 cases were coronary artery expansion patients.Compared with non-expansion patients,levels of CD4+/CD8+,CD3+CD8+,IgG of coronary artery expansion patients were significant different and had statistical difference(t=0.02,0.04,0.03 Pa0.05).Conclusions Patients in the acute period of KD have functional disorder in modulating and humoral immunity,ratios of CD4+ and CD8+ decreased;cases of children patients that have high levels of CD3+CD8+ and IgG have a more incidence of coronary artery expansion and poor prognosis.
【CateGory Index】: R725.4
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Chinese Journal Full-text Database 1 Hits
1 ZHU Wei-dong, LIU Te-chang (Guangzhou Children's Hospital, Guangzhou, Guangdong 510120, P.R.China);Study on changes of platelet parameter and immunoglobulin in children with Kawasaki disease[J];China Journal of Modern Medicine;2005-09
Chinese Journal Full-text Database 10 Hits
1 GUAN Jie,WU Yan-min,WANG Hui,QIAN Li-li,Li Dian-jun,(Department of Immunology,Qiqihaer Medical College,Qiqihaer 161042,China);Effects of Chitosan Oligosaccharide and Bifidobacteria on Immune Function in Tumor-bearing Mice[J];Carcinogenesis,Teratogenesis & Mutagenesis;2007-06
2 LIU Gui-ying,ZHANG Xiao-hong,DU Jun-bao,et al(Pediatrics Department,Beijing Anzhen Hospital,Beijing 100029);The level and clinical value of anti-beta 2-glycoprotein 1 antibodies in the plasma of children with Kawasaki diseases[J];Beijing Medical Journal;2007-10
3 KONG Ying1,ZHOU Yan-bing1,WANG Dong-sheng1,WANG Qing-guang2,WANG Hao3,CHEN Dong1,LU Lian-fang1 (1.Department of General Surgery,the Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,Shandong,China;2.Department of General Surgery,the First Hospital of Zibo,Zibo 255200,Shandong,China;3.Department of General Surgery,the People's Hospital of Dongying,Dongying 250062,Shandong,China);Effect of fast tract surgery on humoral immunity and clinical index of gastric cancer patients[J];Parenteral & Enteral Nutrition;2009-04
4 DAI Ji-Hong1,WANG Yong-Hong2,ZHOU Yuan-Da3,HE Hai-Xia3 1Center for Respiratory Diseases, Children's Hospital, Chongqing University of Medical Sciences, Chongqing 400014, China, 2Department of Neurology, First Affiliated Hospital, 3Department of Pharmacy, College of Clinical Medicine, Chongqing University of Medical Sciences, Chongqing 400016, China;Modulation of IL-13 mRNA,TNF-α mRNA and IgE with Chinese herbal drugs in rats with bronchial asthma[J];Journal of the Fourth Military Medical University;2008-11
5 XIONG Wei1,ZHENG Pei-Yu2,ZHANG Yu3,DAI Ji-Hong4,HE Hai-Xia51Department of Pediatrics,2Department of Pharmacy,Chongqing Ninth People's Hospital,Chongqing 400700,China,3Departement of Emergency,First Affiliated Hospital,Third Military Medical University,Chongqing 400016,China,4Centre of Respiratory Diseases,Affiliated Children's Hospital,Chongqing Medical University,Chongqing 400014,China,5Laboraory of Pharmacology,Chongqing Medical University,Chongqing 400016,China;Modulation of IL-18 mRNA,TNF-α mRNA and IgE with Chinese herbal drugs in rats with bronchial asthma[J];Journal of the Fourth Military Medical University;2009-08
6 ZHAO Wen-hua1,2,XIA Xue-shan3 (1.Institute of Medical Biology,Chinese Academy of Medical Science/Peking Union Medical College,Kunming,Yunnan,650118,China;2.Yunnan Tropical and Subtropical Animal Viral Diseases Laboratory,Kunming,Yunnan,650224,China;3.Kunming University of Science and Technology,Kunming,Yunnan,650224,China);Advance in the Field of Toll-like Receptors(TLRs)[J];Progress in Veterinary Medicine;2007-10
7 PU Xiao-qin(People's Hospital of Nanchuan County,Chongqing Nanchuan 408400,China);Observation of 15 cases of paroxysmal supravent-ricular tachycardia treated with aramine[J];Journal of Pediatric Pharmacy;2005-06
8 ZHOU Jian,JIANG Hong (Changzhou NO.2 Hospital, affiliated to Nanjing Medical University, Jiangsu Changzhou 213003, China);Changes of platelet parameter and of T lymphocyte subsets in children with Kawasaki disease[J];Journal of Pediatric Pharmacy;2007-04
9 YANG Ming-yu,ZHANG Ming,WANG Dan∥The Affiliated Hospital of Guilin Medical College,Guilin 541001,China;A study of C reactive protein concentration and its correlation with myocardial injury markers in acute viral myocarditis[J];Acta Medicinae Sinica;2009-03
10 ZHANG Lin The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine,Changsha,China,410007;An Experimental Study of the Influence of Qinghuang Mouth Tables to Saliva Immune Factors in the Oral Candida Albicans Patients[J];Guiding Journal of Traditional Chinese Medicine and Pharmacy;2009-07
China Proceedings of conference Full-text Database 3 Hits
1 ;前列腺癌浸润性树突状细胞CD1a、CD83的表达及与临床指标的相关性分析[A];[C];2009
2 ;“扶正抑瘤法”对前列腺癌患者原发灶树突状细胞CD1a、CD83表达的影响[A];[C];2009
3 ;前列腺癌浸润性树突状细胞CD1a CD83的表达及与临床指标的相关性分析[A];[C];2009
【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 Gu Xiaohua,Tang Pingya, Fang Lihui et al. Department of Pediatrics,Zhongnan Hospital, Wuhan University, Wuhan 430071;Changes in platelet indexes and diagnosis and treatment of Kawsaki Disease in children.[J];Central China Medical Journal;2004-03
2 PENG Ming-xia, SHENG Xiu-zhen, CHEN Ji-yuan (Department of Dermatology; Department of Pediatrics , Baogang Hospital, Shanghai Second Medical University, Shanghai 201900, China);Analysis of count and average volume of blood platelet and metabolite of Kawasaki's disease[J];Acta Universitatis Medicinalis Secondae Shanghai;2004-06
3 JIANG Li-xue 1,SHI Gui-ying 2,SHI Xue-geng 2,XU Yi-ping(1. Department of Respiratory Diseases,Renji Hospital,Shanghai Second Medical University, Shanghai 200001;2. Department of Biophysics,Shanghai Second Medical University,Shanghai 200025);Study on Change of the CD4~+ and CD8~+T Cell Populations in Peripheral Circulation Producing IFN-γ and IL-4 in Neonates,Children and Adults[J];Shanghai J.of Immunology;2002-01
4 Wang Hongwei, Cheng Peixuan,Wang Hua. Department of pediatrics, Tongji Hospital, Tongji Medical University, Wuhan 430030;Inhibition of PDGF expression in monocyte and apoptosis of endothelial cells by γ globulin in children with Kawasaki disease[J];Chinexe Journal of Pediatrics;1998-06
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