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《Journal of Applied Clinical Pediatrics》 2009-24
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Expression of Vascular Endothelial Growth Factor in Pulmonary Tissue of Newborn Rats with Pulmonary Hemorrhage

CHEN Yu-jun1a,CHEN Ke-zheng2,LIU Tang-wei1b,PANG Yu-sheng1a(1a.Pediatric Intensive Care Unit;1b.Department of Cardiovascular Medicine,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,Guangxi Zhuang Autonomous Region,China;2.Neonatal Intensive Care Unit,Guangzhou Children's Hospital,Guangzhou 510120,Guangdong Province,China)  
Objective To explore the expression of vascular endothelial growth factor(VEGF)in pulmonary tissue of newborn rats developing pulmonary hemorrhage.Methods Thirty-four 7-8 days old newborn Wistar rats were randomly divided into control group(n=10),hypothermia-hypoxia group(n=12)and rewarming-reoxygenating group(n=12).Rats in control group were exposed to normothermia inhaling room air,rats in hypothermia-hypoxia group were exposed to hypothermia(10±1)℃ and hypoxia(reoxygenated 50-60 mL/L)for 6 hours,and rats in rewarming-reoxygenating group were exposed to hypothermia and hypoxia for 6 hours,and then rewarmed(37 ℃)and reoxygenated 950 mL/L for 2 hours.Gross anatomical changes and histological changes(HE staining)of lungs were observed,VEGF expression was detected by immunohistochemical method.Results Two rats in hypothermia-hypoxia group and 4 rats in rewarming-reoxygenating group died while none in control group.Lungs of hypothermia-hypoxia group and rewarming-reoxygenating group represented edema and punctiform,local and diffuse pulmonary hemorrahge.Histopathological changes included pulmonary edema,alveolar septum broken,pulmonary alveoli fusion and pulmonary hemorrahge.More severe pathological change could be found in rewarming-reoxygenating group.Optical density value of VEGF expression in 3 groups were 0.29±0.06,0.36±0.05,0.22±0.05,respectively,there were significant diffe-rences of VEGF expression between 3 groups(F=15.64 P0.01).Compared with control group,VEGF expression increased significantly in hypothermia-hypoxia and rewarming-reoxygenating groups(P0.05,0.01),and especially in rewarming-reoxygenating group compared with that of hypothermia-hypoxia group(P0.01).Conclusion Overexpression of VEGF may contribute to pulmonary hemorrhage in newborn rats induced by hypothermia-hypoxia/rewarming-reoxygenating.
【Fund】: 广州市计划委员会项目资助[穗科技(1998)11号]
【CateGory Index】: R722.1
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【References】
Chinese Journal Full-text Database 2 Hits
1 FENG Shu-ying1,LI San-qiang2,LIU Xiao-zhuan2,REN Jiang-tao2(1.Medical Technology and Engineering School,Henan University of Science and Technology,Luoyang 471003,Henan Province,China;2.Medical College,Henan University of Science and Technology,Luoyang 471003,Henan Province,China);Expression of vascular endothelial growth factor in liver tissue of mice with acute liver injury induced by carbon tetrachloride[J];Journal of Xinxiang Medical College;2011-03
2 CHEN Lu-qi1,CHEN Jing2,ZHANG Chun-yan1,XU Xiao-ying1,LIU Xiu-xia1(1.Department of Respiratory Medicine,Henan Provincial Chest Hospital,Zhengzhou 450003,Henan Province,China;2.Henan Red Cross Blood Center,Zhengzhou 450003,Henan Province,China);Effect of intrathoracic injection of recombinant human endostatin combined with chemotherapy in treatment of malignant pleural effusion[J];Journal of Xinxiang Medical College;2012-12
【Citations】
Chinese Journal Full-text Database 7 Hits
1 HE Juan,TAO Li,LV Hui.(Guangzhou Children's Hospital Affiliated to Guangzhou Medical College,Guangzhou,Guangdong 510120,China);Regulation role of hypoxia inducible factor-1 on hypoxia induced alveolar epithelial cell apoptosis[J];Chinese Journal of Child Health Care;2007-02
2 ZHANG Yi-Qian~1 ZHANG Zhong-Ming~1 YAN Ying-Qun~1 DONG Hong-Yan~2 1 Department of Cardiothoracic Surgery,Affiliated Hospital;2 Neurobiological Research Center,Xuzhou Medical College,Xuzhou 221002,China;Delayed disappearance of h-VEGF_(165) mRNA and protein under regulation of hypoxic response element[J];Acta Physiologica Sinica;2006-03
3 CHEN Yu-jun1a,CHEN Ke-zheng2,LIU Tang-wei1b, PANG Yu-sheng1a(1a.Department of Pediatric Intensive Care Unit;1b.Department of Cardiovascular Medicine,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China;2.Department of Nechatal Intensive Care Unit,Guangzhou Children′s Hospital,Guangzhou 510120,China);Expression and Role of Vascular Endothelial Growth Factor in Pulmonary Tissue of Newborn Rats with Pulmonary Hemorrhage[J];Journal of Applied Clinical Pediatrics;2007-06
4 YANG Zeng-zhou1,XI Hong-jun2,Hou Jin-rong1(1.Department of Chest Surgery,the People′s Hospital of Linzhou City,Linzhou 456550,China;2.Department of Chest Surgery,the First Affiliated Hospital of Xinxiang Medical College,Weihui 453100,China);Effect of vascular endothelial growth factor-C and vascular endothelial growth factor receptor-3 on lymph node metastasis of esophageal squamous cell carcinoma in high risk area[J];Journal of Xinxiang Medical College;2008-01
5 LI Hong-jiang,ZHANG Ying-hui,LIU Cui-hua,et al(Department of Nephrology,Children′s Hospital of Zhengzhou,Zhengzhou 450053,China);Correlation of plasma vascular endothelial growth factor,urine microalbumin and β_2-microglobulin with early renal injury in children with Henoch-Schenlein purpura[J];Journal of Xinxiang Medical College;2008-02
6 LI Wan-cheng*,LIU Wei-jia,LI Yan-ping,LIU Dai-shun,LIU Yong,WEN Fu-qiang,FENG Yu-lin.*Department of Respiratory Medicine,West China Hospital,Sichuan University.Chengdu,Sichuan,610041,China;Effect of SU5416 on the inflammation of pulmonary fibrosis in mice[J];Chinese Journal of Respiratory and Critical Care Medicine;2007-01
7 MA Shao-lin, WANG Xiao-hong, ZHU Xiao-ping, et al. Department of Intensive Care Unit, the Affiliated Hospital of Ningxia Medical College, Yinchuan 750004, China;Relationship between vascular endothelial growth factor and acute respiratory distress syndrome[J];Chinese Journal of Critical Care Medicine;2007-10
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 ;Evaluation on curative effect of low molecular weight heparin calcium in treatment of early renal injury in children with allergic purpura[J];Journal of Jilin University(Medicine Edition);2012-01
2 ZHOU Tie-jun1,XIANG Li2,GONG Li1,et al.(1.Department of Pathology,2.Department of Medical Microbiology and Parasitology,Luzhou Medical College,Luzhou 646000,China);Expressions of vascular endothelial growth factor-C and its receptor in cervical squamous cell carcinoma and their role in lymph metastasis[J];Chongqing Medicine;2010-05
3 WU Chun-ying,YOU Shang-you,LU Jian-sheng,HU Hong-bing,KANG Shi-xiu,ZHOU-Quan,SUN Jin-zhi(Wuhan Children's Hospital,Wuhan 430016,Hubei,China);Change of histamine level in the lungs of newborn rats with pulmonary hemorrhage[J];Journal of Clinical Pediatrics;2009-07
4 CHEN Yu-jun1,LIU Tang-wei2,CHEN Ke-zheng3,PANG Yu-sheng1(1.Department of Pediatric Intensive Care Unit,The First Affiliated Hospital,Guangxi Medical University,Nanning 530021,Guangxi,China;2.Department of Cardiology,The First Affiliated Hospital,Guangxi Medical University,Nanning 530021,Guangxi,China;3.Neonatal Intensive Care Unit,Guangzhou Children's Hospital,Guangzhou 510120,Guangdong,China);The study of bosentan on prevention of pulmonary hemorrhage in newborn rats[J];Journal of Clinical Pediatrics;2010-11
5 Hao Zhang a△, Hongyan Dong b△, Bo Jianga, Zheng Wanga, Rui Chena, Zhifeng Zhangb, Zhongming Zhanga* aInstitute of Cardiovascular Disease, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu 221002, China; bCenter of Biological Research, Xuzhou Medical College, Xuzhou, Jiangsu 221002, China.;Hypoxic response elements and Tet-On advanced double-controlled systems regulate hVEGF_(165) and angiopoietin-1 gene expression in vitro[J];生物医学研究杂志(英文版);2011-03
6 LIU Min,LI Song,ZHANG Yu-miao,LIU Chun-hui,SHI Han-wen.Department of Rehabilitation,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China;Expressions and significances of vascular endothelial growth factor in hemangioblastoma[J];Journal of Brain and Nervous Diseases;2012-06
7 CHEN Yu-jun1a,CHEN Ke-zheng2,LIU Tang-wei1b, PANG Yu-sheng1a(1a.Department of Pediatric Intensive Care Unit;1b.Department of Cardiovascular Medicine,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China;2.Department of Nechatal Intensive Care Unit,Guangzhou Children′s Hospital,Guangzhou 510120,China);Expression and Role of Vascular Endothelial Growth Factor in Pulmonary Tissue of Newborn Rats with Pulmonary Hemorrhage[J];Journal of Applied Clinical Pediatrics;2007-06
8 MA Zu-xiang, ZU Ying, BAO Yan-min, DAI Qiang-lei, LI Xiang-lei, ZHAO Wei-ling, LI Yong-bai(Department of Nephrology and Immunology, Shenzhen Children′s Hospital, Shenzhen 518026, Guangdong Province,China);Expression of Costimulatory Molecules of Peripheral Blood Mononuclear Cells in Children with Henoch-Schonlein Purpura and Its Significance[J];Journal of Applied Clinical Pediatrics;2008-21
9 WU Hong-mei ,BAO Hua-ying, ZHANG Wei-zhen, HAN Yuan, CHEN Ying, HUANG Song-ming(Department of Nephrology, Nanjing Children′s Hospital Affiliated to Nanjing Medical University, Nanjing 210008, Jiangsu Province ,China);Early Diagnosis of Henoch-Schonlein Purpura Nephritis[J];Journal of Applied Clinical Pediatrics;2008-21
10 CHEN Nian-fa,DUAN Yong-qiang(Department of Pediatrics,the First Hospital of Huangshi,Huangshi 435001,Hubei Province,China);Relationship between Urine Albumin and Vascular Endothelial Growth Factor in Children with Henoch-Schonlein Purpura[J];Journal of Applied Clinical Pediatrics;2008-21
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 WANG Jinwan, SUN Yan, LIU Yongyu, YU Qitao, ZHANG Yiping, LI Kai, ZHU Yunzhong, ZHOU Qinghua, HOU Mei, GUAN Zhongzhen, LI Weilian, ZHUANG Wu, WANG Donglin, LIANG Houjie, QIN Fengzhan, LU Huishan, LIU Xiaoqing, SUN Hong, ZHANG Yanjun, WANG Jiejun, LUO Suxia, YANG Ruihe, TU Yuanrong, WANG Xiuwen, SONG Shuping, ZHOU Jingmin, YOU Lifen, WANG Jing, YAO Chen.  Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021, P.R.China;Results of randomized, multicenter, double-blind phase Ⅲ trial of rh-endostatin (YH-16) in treatment of advanced non-small cell lung cancer patients[J];Chinese Journal of Lung Cancer;2005-04
2 SHANG Quanliang,XIAO Enhua,ZHOU Qichang,WU Haijun (Department of Radiology,Second Xiangya Hospital,Central South University,Changsha 410011,China);MVD and VEGF expression in the acute liver injury treated with allogeneic MBMCs transplantation[J];Journal of Central South University(Medical Science);2009-08
3 WU Qiong,QIN Shu-kui,WANG Jie-jun,QU Wen-shu,YIN Xiao-jin,CHEN Ya-li,HUA Hai-qing,WEN Yong.Department of Oncology,the Affiliated Changzheng Hospital of the Second Military Medical University,Shanghai 200433,China;Experimental study on antiangiogenic effects of endostar combined with cisplatin[J];Chinese Clinical Oncology;2008-05
4 ZENG De,LIN Ying-cheng,WANG Hong-biao,LIN Wen-zhao,CHEN Jiong-yu,HONG Chao-qun.Department of Medical Oncology,Cancer Hospital of Shantou University Medical College,Shantou 515031,China;Inhibitory effect of rh-endostatin on vasculogenic mimicry in nasopharyngeal cancer cell line HNE-1 in vitro[J];Chinese Clinical Oncology;2008-06
5 LIU Xiu-feng,QIN Shu-kui,WANG Lin,CHEN Ying-xia,HUA Hai-qing,YANG Ning-rong,HUANG Yong,GONG Xin-lei.Department of Medical Oncology,Cancer Center of PLA,81 Hospital of PLA,Nanjing 210002,China;Clinical study of endostar on malignant cavity effusion[J];Chinese Clinical Oncology;2011-09
6 TONG Wan-ning,CAO Yu-shu,ZHUO An-shan,XU Shi-lin.Department of Respiratory Medicine,No.411 Hospital of PLA,Shanghai 200081,China;Efficacy of pleurodesis combined with pemetrexed on elderly patients with malignant pleural effusion caused by non-small cell lung cancer[J];Chinese Clinical Oncology;2012-02
7 SUN Hao,QIAO Hong-mei,LU Ji-rong(Department of Pediatrics,the First Hospital of Jilin University,Changchun 130021,Jilin Province,China);Relationships between Vascular Endothelial Growth Factor and Matrix Metalloproteinase-9 with Bronchial Asthma[J];Journal of Applied Clinical Pediatrics;2011-04
8 ZHOU Wei-fang1,CHENG Yu-qing2,ZHANG Su3,YUAN Hong-yan4,XIE Ke-ming1(1.Dept of Pathophysiology,3.Dept of Histoembryology,Medical School of Suzhou University,4.Grade 2001 Adult Educational School of Suzhou University,Jiangsu Suzhou 215123,China;2.Dept of Pathology,the Second People Hospital of Changzhou,Jiangsu Changzhou 213003,China);Expression of HIF-1αin LPS-induced Mouse Acute Inflammatory Hepatic Injury[J];Suzhou University Journal of Medical Science;2007-01
9 Wei-Ping Li,Bao-Yang Zhang, Department of Digestive Diseases,Huzhou Central Hospital,Huzhou 313000,Zhejiang Province, China Hao-Yang Ren, General Hospital of Chinese PLA, 100853 Beijing, China Chao-Hui Yu,You-Ming Li, Department of Digestive Diseases, the First Hospital of Zhejiang University Medical College, Hangzhou 310009, Zhejiang Province, China;Expression of vascular endothelial growth factor in chronic alcoholic liver fibrosis in rats[J];World Chinese Journal of Digestology;2006-18
10 YANG Zeng-zhou1,XI Hong-jun2,Hou Jin-rong1(1.Department of Chest Surgery,the People′s Hospital of Linzhou City,Linzhou 456550,China;2.Department of Chest Surgery,the First Affiliated Hospital of Xinxiang Medical College,Weihui 453100,China);Effect of vascular endothelial growth factor-C and vascular endothelial growth factor receptor-3 on lymph node metastasis of esophageal squamous cell carcinoma in high risk area[J];Journal of Xinxiang Medical College;2008-01
【Secondary References】
Chinese Journal Full-text Database 3 Hits
1 ZHU An-ni;LI Rui;LIU San-hai;QIAO Yan-xue;FENG Shi;YUAN Shao-xin;ZHANG Jian-ping;School of Basic Medical Sciences,Beijing University of Chinese Medicine;Institute of Infectious Diseases,Beijing Ditan Hospital,Capital Medical University;Beijing Key Laboratory of Emerging Infectious Diseases;;Establishment of carbon tetrachloride-induced acute liver injury murine model[J];Chinese Journal of Liver Diseases(Electronic Version);2014-01
2 ZHOU Jun-wei(Department of Oncological Surgery,the First Hospital of Huangshi City,Huangshi 435001,Hubei Province,China);Expression of vascular endothelial growth factor and microvessel density in elderly gastric cancer and the relationship with prognostic[J];Journal of Xinxiang Medical College;2012-03
3 CHEN Lu-qi1,CHEN Jing2,ZHANG Chun-yan1,XU Xiao-ying1,LIU Xiu-xia1(1.Department of Respiratory Medicine,Henan Provincial Chest Hospital,Zhengzhou 450003,Henan Province,China;2.Henan Red Cross Blood Center,Zhengzhou 450003,Henan Province,China);Effect of intrathoracic injection of recombinant human endostatin combined with chemotherapy in treatment of malignant pleural effusion[J];Journal of Xinxiang Medical College;2012-12
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 ;Changes of plasma VEGF level in patients suffering from primary and recurrent high altitude pulmonary edema[J];Acta Academiae Medicinae Militaris Tertiae;2005-08
2 LI Sheng Qing 1, LI Huan Zhang 1 , YANG Qiao Xin 2 , NI Dian Tao 1, BAI Chang Qing 1 1 Department of Respirations, Xijing Hospital, 2 Department of Microbiology, Faculty of Preclinical Medicine, Fourth Military Medical University, Xian 710033, China;Expression of fusion gene TGF-βRⅡ/Fc in Bac-to-Bac baculovirus expression system[J];Journal of The Fourth Military Medical University;2003-04
3 TAO Li, CHEN Ke-zheng (Department of Neonatoloy, Affiliated Children Hospital, Guangzhou Medical College, Guangzhou 510120,China);Expression of HIF-1α Protein in Pulmonary Tissue of Newborn Rats with Pulmonary Hemorrhage Induced by Hypothermia-hypoxia[J];Academic Journal of Guangzhou Medical College;2004-03
4 XU Shuling,CUI Yulin,XU Shuyan,et al Zhengzhou Health Care Hospital for Women and Children,Zhengzhou 450012,China;Clinical Analysis of Mechanical Ventilation Treatment for Premature Infant Pneumorrhagia 96 Cases[J];Journal of Medical Forum;2005-04
5 ;Advances in the studies of VEGF and its receptors[J];Journal of Regional Anatomy and Operative Surgery;2004-02
6 Nie Xiuhong,Li Xiaojing,Wang Shuo,Guo Deyu(Department of Respiratory Medicine,Xuanwu Hospital,Capital University of Medical Sciences);The Changes of Vascular Endothelial Growth Factor in the Early Period of Acute Lung Injury in Rabbit[J];Journal of Capital University of Medical Sciences;2006-01
7 ZHANG Yi-Qian~1 ZHANG Zhong-Ming~1 YAN Ying-Qun~1 DONG Hong-Yan~2 1 Department of Cardiothoracic Surgery,Affiliated Hospital;2 Neurobiological Research Center,Xuzhou Medical College,Xuzhou 221002,China;Delayed disappearance of h-VEGF_(165) mRNA and protein under regulation of hypoxic response element[J];Acta Physiologica Sinica;2006-03
8 ZHANG Yuan-hai,XIANG Ru-lian,WEN Huai-kai,ZHU Mao-ping,LU Wen-wen,WU Rong-zhou,CHEN Qi(Department of Pediatrics,Yuying Children′s Hospital Affiliated to Wenzhou Medical College,Wenzhou 325027,China);Changes of Vascular Endothelial Growth Factor in Children with Cyanotic Congenital Heart Disease[J];Journal of Applied Clinical Pediatrics;2006-01
9 ZHANG Jian-jiang,YI Zhu-wen,HE Xiao-jie,YANG Hua-bin,DING Juan-juan,MO Shuang-hong(Laboratory of Pediatric Nephrology,the Second Xiangya Hospital of Centralsouth University,Hunan Province Clinical Center of Pediatric Nephrology,Changsha 410011,China);Renal Interstitum Vascular Lesions in Children with Purpura Nephritis and Its Relationship with Clinic[J];Journal of Applied Clinical Pediatrics;2006-08
10 SHI Xuan~(1a),LI Yan-zhi~2,WEI Jin-kai~(1a),DU Chang-jiang~(1a),CHOU Guang-cheng~(1b)(1a.Department of Pediatrics;1b.Clinical Laboratory,the Affiliated Hospital of Heibei University,Baoding 071000,China;2.Department of Pediatrics,the Second Affiliated Hospital of Hebei Medical College,Shijiazhuang 050071,China);Dynamic Changes of Serum Levels of Vascular Endothelial Growth Factor in Newborn Infants with Hypoxic-Ischemic Encephalopathy and Their Clinical Significance[J];Journal of Applied Clinical Pediatrics;2006-12
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