Full-Text Search:
Home|About CNKI|User Service|中文
Add to Favorite Get Latest Update

Effect of Transcatheter Theraphy on Myocardium for Patent Ductus Arteriosus

YANG Gui-ming,JIANG Rong,ZHAO Sheng,LIU Feng,HUANG Xiao-bi(Department of Cardiology,Pediatric Clinical College of Anhui Medical University,Anhui Provincial Children′s Hospital,Hefei 230051,Anhui Province,China)  
Objective To study whether the transcathete theraphy for patent ductus arteriosus(PDA) an cause myocardial injury and inflammatory reaction,and to analyze the influencing factors on myocardial injury.Methods The blood samples were collected(basal,imme-diate post procedure,at 4 h,2 d,3 d and 7 d post procedure),from 37 consecutive patients with PDA,who were hospitalized in Anhui Provincial Children′s Hospital from Oct.2008 to Aug.2010.The levels of cardiac troponin I(cTnI) and C reactive protein(CRP) were detected by enzyme linked immunosorbent assay.The related risk factors(age,the size of defect,duration of exposition and dose of contrast agent) were sought.The statistical analysis of the results were performed by SPSS 13.0 software.Results The cTnI levels at immediate post procedure,4 h,2 d and 3 d were 0.08(0.00-1.37) μg·L-1,0.09(0.00-0.68) μg·L-1,0.06(0.00-0.96) μg·L-1 and 0.04(0.00-0.96) μg·L-1,which were higher than that before procedure [0.05(0.00-0.58) μg·L-1].The cTnI level at 7 d was lower than that before procedure.The peak levels of cTnI occurred at 4 h post procedure and the elevation of cTnI was significant(P0.05).All the cTnI levels post procedure were lower than normal level in children.The CRP levels began to ascend at 4 h[0.36(0.00-28.00) mg·L-1] after the procedure,and reached peak levels at 3 d post procedure,then decreased.The CRP levels at 3 d and 7 d post procedure were higher than that before procedure and the differences were significant(Pa0.05).The cTnI levels at post procedure weren′t significantly correlated with age,duration of exposure,size of defect and dose of contrast material.Conclusions Transcatheter closure of PDA is safe and effective without causing obvious myocardial injury and inflammatory reaction.
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©CNKI All Rights Reserved