Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Applied Clinical Pediatrics》 2012-20
Add to Favorite Get Latest Update

Changes of Serum Interleukin-8 Level and Neutrophil Adhesion Molecule CD_(11b) Expression in Newborns with Hypoxic-Ischemic Encephalopathy

LIU Hai-ying (Department of Neonatology,the First Affiliated Hospital of University of South China,Hengyang 421001,Hunan Province,China)  
Objective To observe the changes and clinical significance of peripheral blood interleukin-8(IL-8) level and neutrophil adhesion molecule CD11b expression in newborns with hypoxic-ischemic encephalopathy(HIE). Methods Ninety-four neonates,including 25 cases of mild HIE,31 cases of moderate HIE,and 38 cases of severe HIE were selected as HIE group.At the same time,32 cases of healthy newborns were selected as healthy control group.The levels of serum IL-8 and CD11b expression in 2 groups were measured by enzyme linked immunosorbent assay and flow cytometry,respectively.Correlation analysis was performed between IL-8 and CD11b in children with HIE. Results The serum IL-8 level and CD11b expressions were significantly higher in HIE group than those in healthy control group(Pa0.01).Compared with healthy control group,serum IL-8 level and CD11b expression in mild,moderate and severe HIE patients were markedly increased(Pa0.05),the differences among the 3 groups were also significant(Pa0.05),and they were the highest in patients with severe HIE.There were positive correlation between IL-8 and CD11b in HIE group(r=0.84,P0.01). Conclusions IL-8 and CD11b may play significant roles in the pathogenesis of HIE,which can be as new indicators for assessing the severity and predicting the prognosis of HIE.
【Fund】: 衡阳市科技局研究资助项目(2011KJ43)
【CateGory Index】: R722.1
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 6 Hits
1 LU Fei,YANG Ming-hua,QIAN Zhao-xia (Harbin Children's Hospital,Harbin 150010,China);Clinical Significance of the Change of Serum Interleukin-8 and Interleukin-10 Level in Neonatal Hypoxic-ischemic Encephalopathy[J];Heilongjiang Medical Journal;2009-09
2 LI Xi-hong(Department of Pediatrics,West China Second University Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China);Diagnosis and Therapy of Hypoxic-Ischemic Encephalopathy in Newborn Infants in China[J];Journal of Applied Clinical Pediatrics;2010-14
3 LIU Hai-ying(Department of Neonatology,the First Affiliated Hospital,University of South China,Hengyang 421001,Hunan Province,China);Changes and Significances of Serum Levels of Macrophage Migration Inhibitory Factor,Tumor Necrosis Factor-α and Interleukin-1β in Newborn Infants with Hypoxic-Ischemic Encephalopathy[J];Journal of Applied Clinical Pediatrics;2011-14
4 HAO Lihong,MA Qingrong,ZHANG Wenshuang,LIU Xiaojun,XU Li,GUO Jing,ZHANG Fang,GAO Haitao Tianjin Children’s Hospital, Tianjin 300074, China;Early Diagnosis of Neonatal Infection by Evaluation of Neutrophil Adhesion Molecule CD11b and CD64 Expression[J];Tianjin Medical Journal;2011-04
5 PAN Yan-feng,ZHANG Gui-xin(Department of Neonatology,the First People′s Hospital of Zhumadian City,Zhumadian 463000,Henan Province,China);Changes and clinical significance of serum cardiac troponin and creatine kinaes BB isozyme in newborns with hypoxic-ischemic encephalopathy[J];Journal of Xinxiang Medical College;2012-02
6 LIU Wen-dong,WANG Cai-xia,JIN Xin,Li Hong.(Qingdao Municipal Hospital,Qingdao 266011,China);Study on the clinical significance of cytokines in newborns with hypoxic-ischemic encephalopathy[J];Chinese Journal of Birth Health & Heredity;2012-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 WU Honghua1 YANG Cheng1 SHI Zengli2 et al 1 Department of Anatomy,Binzhou Medical University,Binzhou 256603;2Department of Pathophysiology,Binzhou Medical University;Research of ligustrazine on brain tissue proinflammatory cytokine in rats after hypoxic-ischemic brain damage[J];Journal of Binzhou Medical University;2007-03
2 Xiao Yi FANG, Yan Jun LU, Bei Yan WU, Xiu Yin ZHOU, Ni Yang LIN. Department of Pediatrics, First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, China;Serum interleukin-8 levels in neonates with hypoxic ischemic encephalopathy[J];The Chinese Journal of Contemporary Pediatrics;2004-02
3 Li Manku,Zhang Xiaoli,Wang Xiaohong,Wang Yuchao,Wang Yong,Zhang Jisheng△(Department of Clinical Laboratory,the First Affiliated Hospital,Jiamusi University,Jiamusi,Heilongjiang 154003,China);Application value of cord serum NF-H and S100β protein detection in diagnosis of neonatal hypoxic-ischemic encephalopathy[J];International Journal of Laboratory Medicine;2013-09
4 LU Fei,YANG Ming-hua,QIAN Zhao-xia (Harbin Children's Hospital,Harbin 150010,China);Clinical Significance of the Change of Serum Interleukin-8 and Interleukin-10 Level in Neonatal Hypoxic-ischemic Encephalopathy[J];Heilongjiang Medical Journal;2009-09
5 ZHUANG Tan-yue Department of Pediatrics,Zhengzhou People's Hospital,Zhengzhou 450003,China;Evaluation of therapic effect on cerebroprotein hydrolysate injection for cerebral palsy patients[J];Journal of Medical Forum;2011-13
6 LIU Gui-ling,ZHAO Li-na,REN Chang-jun,WANG Na(Department of Pediatrics,The First Hospital of Hebei Medical University,Shijiazhuang 050031,Hebei,China);Serum levels of oexin and leptin and their significance in neonates with hypoxic-ischemic encephalopathy[J];Journal of Clinical Pediatrics;2012-09
7 HUANG Haibo,LIU Haiying,YI Lu(Department of Neonatology,the First Affiliated Hospital,University of South China, Hengyang,Hunan 421001,China);Changes and Significances of Serum Levels of Macrophage Migration Inhibitory Factor and Matrix Metalloproteinase-9 In Newborn Infants With Hypoxic-Ischemic Encephalopathy[J];Medical Science Journal of Central South China;2013-01
8 WANG Ying, YANG Zuqin, SUN Zhongmin, HUANG Yumei (The Second Hospital and Yuying Children's Hospital of Wenzhou Medical College, Wenzhou 325027, Zhejiang, China);Evaluation of SAA and CD64 in early diagnosis of neonatal septicemia[J];Journal of Clinical Pediatrics;2013-06
9 CHENG Fan-ying,LI Jian-xi,ZHAO Ping(Zhuanglang People′s Hospital,Gansu 744699,CHINA);Clinical Nursing Study of the Reform of the Index and Forefinger Vagina Expansion Delivery[J];Heilongjiang Medical Journal;2013-06
10 Wang Tuanmei,Liu Xiaoliang(Central Hospital,Hu Nan,Chang Sha,410000 China);Clinic Significance of Serum Cytokines in Newbeorn with Hypoxie Ischemic Encephalopathy[J];Journal of Hunan Normal University(Medical Sciences);2013-02
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 TIAN Zhao Fang, LI Shu Ting Department of Pediatrics, Second Affiliated Hospital, Nanjing Medical University, Nanjing 210011[;High Dose of Dexamethasone Reduces the Expression of MCP-1 Protein in the Brain of Neonatal Rats with Hypoxia-ischemia[J];CHINESE JOURNAL OF CONTEMPORARY PEDIATRICS;2000-02
2 November 2004, Changsha) The Subspecialty Group of Neonatology, Pediatric Society, Chinese Medical Association;Diagnostic criteria for neonatal hypoxic-ischemic encephalopathy[J];The Chinese Journal of Contemporary Pediatrics;2005-02
3 Li LumingFirst People's Hospital of shangqiu City, Shangqiu, 4761000, China;Study of Changes of Cytokines in HIE[J];Journal of Medical Forum;2003-16
4 WANG Li-zhou,LI Shu-jun,ZHAO Dong-ju,et al.Department of Pediatrics,the First Hospital Affiliated to Xinxiang Medical College,Weihui 453100,China.;Detection of IL-1β and IL-18 in serum of newborns with hypoxic-ischemic encephalopathy[J];Pediatric Emergency Medicine;2005-04
5 LU Qin,WANG Jian,WANG Wei,et al.Department of Pediatrics,Maternity and Infant Health Institute of Huainan,Huainan 232007,China.;Study on the relationship between the neonates with hypoxic ischemic encephalopathy and cellular immune function[J];Pediatric Emergency Medicine;2005-04
6 LIU Jing,CHANG Li-wen.Department of Pediatrics,Tongji Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China.;The regulating effect of cytokines on cerebral hemodynamics in neonates with hypoxic-ischemic encephalopathy and its mechanism[J];Chinese Pediatric Emergency Medicine;2006-02
7 XU Fa-lin~1,ZHU Chang-lian~1,CHENG Xiu-yong~1,JIA Li-ting~2,GENG Lin-lin ~1,QIAO Jun-ying~1,HU Sheng-hai~3(1.Department of Pediatrics;2.Department of Radioimmunity;3.Department of Pharmacy, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052,China);Changes of Cytokines Measurement in Serum and Cerebrospinal Fluid in Asphyxia Ne onates and Its Relationship with Prognostic[J];Journal of Applied Clinical Pediatrics;2005-08
8 LI Yue-mei,HAO Ling,LI Yan-zhi(Department of Pediatrics,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China);Diagnostic Value of Neutrophil CD_(64) in Neonatal Septicemia[J];Journal of Applied Clinical Pediatrics;2006-22
9 HAO Ling1,YANG Heng-wei2,LI Yan-zhi3,LI Yan-min1,LIU Gui-ling1,DONG Hong-hong1(1.Department of Pediatrics,the First Affiliated Hospital of Hebei Medical University,Shijiazhuang 050031,China;2.Department of Neurosurgery,the Second Hospital of Xinji,Xinji 052360,China;3.Department of Pediatrics,the Second Affiliated Hospital of Hebei Medical University,Shijiazhuang 050000,China);Expression of Peripheral Blood Neutrophil CD_(64) in Neonatal Septicemia and Its Clinical Significance[J];Journal of Applied Clinical Pediatrics;2007-22
10 LI Xi-hong(Department of Pediatrics,West China Second University Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China);Diagnosis and Therapy of Hypoxic-Ischemic Encephalopathy in Newborn Infants in China[J];Journal of Applied Clinical Pediatrics;2010-14
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved