Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Applied Clinical Pediatrics》 2012-23
Add to Favorite Get Latest Update

Changes in Content of Von Willebrand Factor and Its Catenase in Placental-Abruption Preterm Infants Cord Blood and Maternal Blood

XU Jing1,2,LI Qiu-ping2,KONG Xiang-yong2,KONG Ling-kai2,CHEN Chong2,YANG Lu1,2,ZHOU Li2,MA Xing-na2,FENG Zhi-chun3(1.Very Preterm Neonatal Intensive Care Unit,Bayi Children′s Hospital Affiliated to Bayi Clinical Medical Institute of the South Medical University,Beijing 100007,China;2.Very Preterm Neonatal Intensive Care Unit,Bayi Children′s Hospital Affiliated to General Hospital of Beijing Military Region,Beijing 100007,China;3.Bayi Children′s Hospital Affiliated to General Hospital of Beijing Military Region,Beijing 100007,China)  
Objective To observe the changes in content of von willebrand factor(VWF)and its catenase(a disintegrin and metalloproteinase with a thrombospondin type 1 motif,member 13,ADAMTS13) in the umbilical cord blood and maternal blood after placental abruption happening and to explore the pathophysiological mechanisms of the coagulation abnormalities of placental abruption. Methods The placental abruption group included the cases admitted to the General Hospital of Beijing Military Region,Obstetrics and Gynecology Hospital of Beijing and Haidian Obstetrics and Gynecology Hospital of Beijing from Nov.2010 to Nov.2011,and the 2 non-placental abruption inpatients closely next to the certain one of the placental-abruption group according to the admission time were included as non-placental abruption group for these hospital.Cord blood and maternal blood were collected from each group of newborns during delivering and VWF/ADAMTS13 were measured by the means of enzyme linked immunosorbent assay. Results Fifty-eight cases were included to the placental abruption group and 116 cases included to the non-placental abruption group.The 95% sided reference value were calculated.Maternal blood:VWF857.80 U·L-1,ADAMTS13119.63 U·L-1;umbilical veins blood:VWF852.71 U·L-1,ADAMTS1328.12 U·L-1;umbilical arterial blood:VWF1 416.96 U·L-1,ADAMTS13147.90 U·L-1;placental tissue: VWF760.66 U·L-1,ADAMTS1327.53 U·L-1.There were discrepancies not only in the maternal blood,umbilical veins blood and umbilical arterial blood of the same group,but each concentration of VWF of the detected subjects in the placental abruption group was much higher than that of the non-placental abruption group,while ADAMTS13 concentration of both maternal and umbilical blood of the placental abruption group was lower than that of the non-abruption group(Pa0.05). Conclusions The concentration of VWF of placental abruption maternal and fetal/neonated body increased greatly and the concentration of ADAMTS13 correspondingly decreased significantly.VWF is one of the factor of hyper-coagulable state and ADAMTS13 may have a protective effect.
【Fund】: 国家自然科学基金(30973210 81070524);; 首都特色临床医学技术发展研究(Z090507017709001)
【CateGory Index】: R714.2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 1 Hits
1 Dandan ZHANG1,Juan XIAO1,Haoliang HUANG 2,Juanjuan CHEN 1,Tao LIU 1,Zongzhi YIN1,Danping GAO 1,Qiong LIU 1,Jihui AI 1,Suhua CHEN 1# 1 Department of Obstetrics and Gynecology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China 2 Department of Obstetrics and Gynecology,the First Hospital of Wuhan,Wuhan 430022,China;Von Willebrand Factor Antigen and ADAMTS13 Activity Assay in Pregnant Women and Severe Preeclamptic Patients[J];华中科技大学学报(医学英德文版);2010-06
【Co-citations】
Chinese Journal Full-text Database 1 Hits
1 Sun Jing1,2,Zhao Xia1,Chen Suhua1 et al 1Department of Obstetrics and Gynecology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China 2Reproductive Center,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052,China;Proximal Carboxyl-terminal Domains of ADAMTS13 under Flow Conditions[J];Acta Medicinae Universitatis Scientiae et Technologiae Huazhong;2011-06
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved