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《Journal of Applied Clinical Pediatrics》 2012-23
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Comparison of Early Stage Effect of Different Resuscitative Fluids in Rat Models with Septic Shock

WEI Dan,WANG Sui-li,DENG Yong-li,ZHONG Jing-zi,LI Mei(Department of Pediatrics,the First Affiliated Hospital of Guangxi Medical University,Nanning 530027,Guangxi Zhuang Autonomous Region,China)  
Objective To compare the effects of different fluids for early resuscitation in septic shock. Methods Seventy-two adult male SD rats were divided into 9 groups.(1)normal group(n=8);(2)septic shock group(n=8);(3)intervention groups(n=56):they were divided into 7 subgroups:normal saline group,dextran group,albumin group,saline with dextran group,saline with albumin group,dextran with albumin group and mixture group.Septic shock models were made by injecting endotoxin(10 mg·kg-1) via external jugular vein and then given different fluids.The end point was 1 hour after the resuscitation.Successful resuscitation was defined as that the mean arterial pressure(MAP)recovered to 90% of the basic blood pressure.The MAP was monitored for real time and recorded the time for resuscitation.Blood gas analysis and lactate levels were measured by testing central venous blood.These indexes were compared among different groups. Results The success rates of normal saline group,saline with dextran group,saline with albumin group and mixture group were more than 50%,while the saline group(87.50%) and the mixture group(83.33%) were the highest.There were no significant differences among these 4 groups(F=1.136,P0.05).But the effects of dextran group,albumin group and dextran with albumin group were worse,the albumin group and dextran group were the worst,their success rates were 16.67% and 25.00%.There was significant difference between these 2 groups and the saline group(P0.05).For the average resuscitation time,the saline group was the shortest[(18.50±8.85) min],followed with saline with albumin group,mixture group and normal saline with dextran group.There were no significant differences among these 4 groups(F=1.519,P0.05).But the resuscitation time of dextran group,albumin group and dextran with albumin group were longer than others.There were no significant differences among these 3 groups(F=1.018,P0.05),but there was significant difference between these 3 groups and normal saline group(P0.05).Blood gas analysis in each group compared with the septic shock group,pH value was significantly improved in albumin group and dextran with albumin group;the partial pressure of oxygen improved and the lactate levels decreased in saline group and normal saline with albumin group to compare with septic shock group(P0.05). Conclusions Disturbance of acid-base balance occur in the early stage of shock.The effect of normal saline and saline with albumin group were better than crystalloid with colloid fluids and colloid fluid in the success rate of resuscitation,resuscitation time,improvement of partial pressure of oxygen and reduction of lactate levels.
【Fund】: 广西科技厅自然基金(桂科自0832142)
【CateGory Index】: R459.7
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