Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Applied Clinical Pediatrics》 2012-23
Add to Favorite Get Latest Update

Relationship of Plasma Nesfatin-1 with Growth and Development of Small Gestational Age Infant

CHENG Ya-ying1,ZHAO Xiu-mian1,YIN Jian-ying1,SONG Guang-yao2(1.Department of Pediatrics,Hebei Province People′s Hospital,Shijiazhuang 050051,Hebei Province,China;2.Department of Endocrinology,Hebei Province People′s Hospital,Shijiazhuang 050051,Hebei Province,China)  
Objective To explore the relationship between nesfatin-1 and energy homeostasis in newborns. Methods One hundred and thirteen newborns were divided into 2 groups(preterm infants,n=53;term infants,n=60).The term infants were divided into the follo-wing groups:appropriate for gestational age(AGA) group(n=32) and small for gestational age(SGA) group(n=28).The levels of fasting plasma nesfatin-1,ghrelin,insulin-like growth factor-1(IGF-1),insulin and glucose were measured. Results The fasting plasma concentrations of nesfatin-1,ghrelin and insulin and the homeostasis model assessment insulin resistance index(HOMA-IR) were higher in SGA infants than those in AGA infants(P=0.035 8,0.016 3,0.000 1 and 0.005 1,respectively).The IGF-1 level and homeostasis model assessment insulin secitive index(HOMA-ISI) were lower in SGA infants than those in AGA infants(P=0.033 0 and 0.000 1,respectively).Compared with postnatal day 0(PND0),fasting plasma concentration of nesfatin-1 was lower on PND7 in SGA(P0.000 1) and AGA(P=0.009 4) infants.Then,the level of nesfatin-1 increased gradually,and it was lower on PND28 than PND0 in SGA infants(P0.000 1).Compared with AGA infants,the concentration of nesfatin-1 in SGA infants was higher on PND0(P=0.035 8) and lower on PND7(P=0.000 2) and PND28(P=0.048 8).The correlation analysis for SGA infants showed a negtive correlation between nesfatin-1 and oral calorie intake(r=-0.446,P=0.017 0) and HOMA-ISI(r=-0.398,P=0.036 0).There was positive correlation between nesfatin-1 and HOMA-IR(r=0.430,P=0.023 0). Conclusions Nesfatin-1 is involved in the physiological regulation of food intake and energy homeostasis in newborns.There may be a certain relationship between nesfatin-1 and insulin sensitivity in SGA infants.
【Fund】: 河北省人口计生委科研计划课题(2011-A09)
【CateGory Index】: R722
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 3 Hits
1 LIU Yan-hua,HOU Miao,ZHU Li-jun,GUO Mei,ZHANG Li,LI Xiao-nan(Department of Children′s Health Care,Nanjing Children′s Hospital Affiliated to Nanjing Medical University,Nanjing 210008,Jiangsu Pro-vince,China);Effect of Over-Feeding during Lactation Period on Expressions of Ghrelin in Gastric Tissue and Leptin inSerum in Adult Rats[J];Journal of Applied Clinical Pediatrics;2011-19
2 HU Su-jun1,LI Zhi-rui1,SU Yuan-yuan1,XU Fa-lin1,CHENG Xiu-yong2,WANG Ling1(1.Department of Pediatrics,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China;2.Department of Newborn Intensive Care Unit,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China);Analysis of Weight Development of Low Birth Weight Infants and Its Influence Factors[J];Journal of Applied Clinical Pediatrics;2012-14
3 CHENG Yaying,SONG Guangyao,ZHOU Lixia,CAI Baoping,ZHAO Xiumian,YIN Jianying Department of Pediatrics,Hebei Province People's Hospital,Shijiazhuang 050051,China;Relationship of plasma ghrelin,IGF-1 and insulin with the growth and development of 2-7 year-old children with small for gestational age at birth[J];Journal of Hygiene Research;2012-01
【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 JIANG Hong,LI Xiang-hong,WANG Wei,SONG Zhen-feng,WANG Cui,WANG Qi-hong,SHAO Chang-rong,ZHANG Yi-jie(Department of Neonatology,the Affiliated Hospital of Medical College Qingdao University,Qingdao 266003,Shandong Province,China);Effect of Whey-Predominant Infant Formula on Growth and Amino Acids Metabolism in Newborn Infants[J];Journal of Applied Clinical Pediatrics;2012-19
2 LIANG Xiaoling,NIE Quyan (Department of Obstetrics,Maternal and Child Health Hospital of Heyuan,Heyuan 517000,China);Effect of Neonatus's Mental Care Training Applied in Obstetrics[J];Clinical Medicine & Engineering;2013-04
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Jing,DING Shi-gang,YANG Xue-ling,WANG Ye,ZHANG He-jun (Department of Gastroenterology,Peking University Third Hospital,Beijing 100191,China);Relationship amoung pathological change of gastric mucous,body mass index and the serum levels of ghrelin and leptin[J];Journal of Peking University(Health Sciences);2010-05
2 ;早产儿早期母乳喂养的临床观察[J];Contemporary Medicine;2010-25
3 XIAO Jing,ZHU Fufan(The Second Xiangya Hospital of Central South University,Changsha Hunan 410011,China);Analysis the Correlative Factors of 140 FGR With Different Gestation Ages[J];Journal of Practical Obstetrics and Gynecology;2011-07
4 ZHAO Zi-yan,CHEN Ping-yang(Department of Neonatology,the Second Xiangya Hospital of Central South University,Changsha 410011,Hunan Province,China);Relationships between Low Birth Weight and Insulin Resistance and Adult Cardiovascular Disease[J];Journal of Applied Clinical Pediatrics;2010-08
5 LI Wei1,ZHOU Wei2,RONG Xiao2,ZHENG Xiao-hui1,ZHANG Zhe2,CHEN Xiao-wen2,TAO Li2(1.Department of Pediatrics,Dongguan Taiping People′s Hospital,Dongguan 523905,Guangdong Province,China;2.Department of Neonato-logy,Guangzhou Women and Children′s Medical Center,Guangzhou 510120,Guangdong Province,China);Effects of Enteral Glutamine Supplementation on Very Low Birth Weight Infants[J];Journal of Applied Clinical Pediatrics;2011-13
6 CHENG Wei,WU Hong-min(Department of Neonatology,the First Hospital of China Medical University,Liaoning 110001,Shenyang Province,China);Study of Gastrointestinal Dysfunction in Premature Infants[J];Journal of Applied Clinical Pediatrics;2011-14
7 HU Su-jun1,SU Yuan-yuan1,XU Fa-lin1,WANG Ling1,LI Zhi-rui1,CHENG Xiu-yong2(1.Department of Pediatrics,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China;2.Department of Pediatrics,the Affiliated Third People′s Hospital of Shanghai Jiaotong University Medical College,Shanghai 201900,China);Analysis of Influence Factors and Neurobehavioral Development of Low Birth Weight Infants[J];Journal of Applied Clinical Pediatrics;2011-18
8 GAO Jian-zhi,LI Xin-juan,LI Na-na,et al(College of Basic Medicine,Xinxiang Medical College,Xinxiang 453003,China);Influence of acupuncture on the expression of Bcl-2 and adipocyte apoptosis in simple obesity rats[J];Journal of Xinxiang Medical College;2009-05
9 ZHU Xiao-Lan,SHEN Zong-Ji,SHEN Yue-Ping et al.Department of Gynecology and Obstetrics,the First Affiliated Hospital of Suzhou University,Suzhou 215006,Jiangsu,China;Analysis on follow-up results of physical development of infants aged 0~3 years with fetal growth restriction[J];Maternal and Child Health Care of China;2010-23
10 DONG Wei-Hua,LIU Yi-Fan,FENG Xiao-Lan.Department of Children's Health Care,Qinhuangdao Maternal and Child Health Hospital,Qinhuangdao 066000,Hebei,China;Comparison of physical development between premature infants and full term infants less than one year[J];Maternal and Child Health Care of China;2011-18
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved