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《Journal of Applied Clinical Pediatrics》 2012-23
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Relationship of Plasma Nesfatin-1 with Growth and Development of Small Gestational Age Infant

CHENG Ya-ying1,ZHAO Xiu-mian1,YIN Jian-ying1,SONG Guang-yao2(1.Department of Pediatrics,Hebei Province People′s Hospital,Shijiazhuang 050051,Hebei Province,China;2.Department of Endocrinology,Hebei Province People′s Hospital,Shijiazhuang 050051,Hebei Province,China)  
Objective To explore the relationship between nesfatin-1 and energy homeostasis in newborns. Methods One hundred and thirteen newborns were divided into 2 groups(preterm infants,n=53;term infants,n=60).The term infants were divided into the follo-wing groups:appropriate for gestational age(AGA) group(n=32) and small for gestational age(SGA) group(n=28).The levels of fasting plasma nesfatin-1,ghrelin,insulin-like growth factor-1(IGF-1),insulin and glucose were measured. Results The fasting plasma concentrations of nesfatin-1,ghrelin and insulin and the homeostasis model assessment insulin resistance index(HOMA-IR) were higher in SGA infants than those in AGA infants(P=0.035 8,0.016 3,0.000 1 and 0.005 1,respectively).The IGF-1 level and homeostasis model assessment insulin secitive index(HOMA-ISI) were lower in SGA infants than those in AGA infants(P=0.033 0 and 0.000 1,respectively).Compared with postnatal day 0(PND0),fasting plasma concentration of nesfatin-1 was lower on PND7 in SGA(P0.000 1) and AGA(P=0.009 4) infants.Then,the level of nesfatin-1 increased gradually,and it was lower on PND28 than PND0 in SGA infants(P0.000 1).Compared with AGA infants,the concentration of nesfatin-1 in SGA infants was higher on PND0(P=0.035 8) and lower on PND7(P=0.000 2) and PND28(P=0.048 8).The correlation analysis for SGA infants showed a negtive correlation between nesfatin-1 and oral calorie intake(r=-0.446,P=0.017 0) and HOMA-ISI(r=-0.398,P=0.036 0).There was positive correlation between nesfatin-1 and HOMA-IR(r=0.430,P=0.023 0). Conclusions Nesfatin-1 is involved in the physiological regulation of food intake and energy homeostasis in newborns.There may be a certain relationship between nesfatin-1 and insulin sensitivity in SGA infants.
【Fund】: 河北省人口计生委科研计划课题(2011-A09)
【CateGory Index】: R722
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