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《Journal of Applied Clinical Pediatrics》 2012-23
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Clinical Study of Brain Regional Oxygen Saturation in Early Stage of Preterm Newborns

ZOU Yun-su1,SONG Wen-ying2,ZHOU Xiao-guang1,CHENG Rui1,ZHAO Li1,SUN Yong-ping1,ZHOU Xiao-yu1(1.Neonatal Intensive Care Unit,Nanjing Children′s Hospital Affiliated to Nanjing Medical University,Nanjing 210008,Jiangsu Province,China;2.Department of Gynaecology and Obstetrics,Nanjing Drum Tower Hospital Affiliated to Nanjing University,Nanjing 210008,Jiangsu Pro-vince,China)  
Objective To compare the brain regional oxygen saturation(rSO2) in early stage of preterm newborns with that in healthy term newborns by using near-infrared spectroscopy. Methods There were 77 healthy term newborns enrolled in group A from Nanjing Drum Tower Hospital Affiliated to Nanjing University from Apr.to Jun.in 2011.Sixty-one preterm newborns enrolled in group B from Nanjing Children′s Hospital Affiliated to Nanjing Medical University from Nov.2011 to Mar.2012.rSO2 were examined within 12-24 hours after birth,and clinical conditions and relation with rSO2 were compared between the 2 groups. Results There was no significant difference between the 2 groups in delivery approach and gender(Pa0.05).There were significant differences in gestation age,birth weight and Apgar scores(Pa0.05) between the 2 groups.There was no significant difference between the 2 groups in testing time and pulse oxygen saturation(Pa0.05).The rSO2 in group A was(62.70±3.75)%,and(64.66±3.93)% in group B,with significant difference between the 2 groups(P=0.003).The p(CO2) was(5.26±0.36) kPa in group A,and(6.04±1.18) kPa in group B,with significant difference between the 2 groups(P=0.000). Conclusions Compared with healthy term newborns,preterm newborns showed increased rSO2 within 12-24 hours after birth.This probably is due to the richer cerebral blood flow,higher p(CO2) and regional cerebral hypoxia during early stage after birth.
【Fund】: 南京医科大学科技发展基金面上项目(2011NJMU129)
【CateGory Index】: R722.6
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