Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Applied Clinical Pediatrics》 2012-23
Add to Favorite Get Latest Update

Effects of Long-Term Exposure to Polychlorinated Biphenyls of Low Concentrations on Morphology Development of Zebrafish Retinal

WANG Yan-ping1,CHI Xia2,YANG Lei2,GUO Xi-rong2,TONG Mei-ling2 (1.Department of Pediatrics Neurology,Wuxi People′s Hospital,Wuxi 214023,Jiangsu Province,China;2.Department of Pediatrics,Maternal and Child Health Hospital of Nanjing,Nanjing Medical University,Nanjing 210004,Jiangsu Province,China)  
Objective To explore the effects of low concentration of polychlorinated biphenyls(PCBs) on zebrafish retinal morphology which were exposed to it for a long time. Methods The zebrafishes were divided into normal ones(normal control group) and 0.05 mg·L-1 PCBs treatment ones(experimental group).The retinal morphology changes of zebrafish embryos were observed by light and electron microscope after 7,15,30 days separately. Results 1.Under the light microscope:There was no significant difference on the zebrafish retinal morphology between the 2 groups after 7 days and 15 days,while nuclear chromatin margination,cell vacuolization and reducement of the nuclear numbers were observed after 30 days.2.Under the electronic microscope:There was no obvious influence on the outer segment disk of retinal photoreceptor after 7 days and 15 days in experimental group,while less and smaller outer segment disk of retinal photoreceptor,mitochondrial vacuolization and degeneration and the endoplasmic reticulum expansion were observed after 30 days treatment. Conclusions Long-time exposure to low concentrations of PCBs in daily life will do harm to zebrafish retinal development,thus,should be strengthen the monitoring and controlling of organic pollutants in the environment.At the same time,the presence of low concentrations of PCBs around may also have a certain impact on population health.
【Fund】: 国家自然科学基金(81170889);; 江苏省“六大人才高峰”第七批高层次人才项目(2010001);; 南京市医学科技发展基金(YKK10032)
【CateGory Index】: R774.1
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 1 Hits
1 FU Pei *, YANG Liu , BO Shao ye, NA Xin *Department of Ophthalmology, Shenzhen Hospital, Peking University, Shenzhen 518036,China;A national survey on low vision and blindness of 0-6 years old children in China[J];National Medical Journal of China;2004-18
【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 YAN Xing-ke CHN Hui-ju WANG Fu-chun,et al Acupuncture & Tuina College of Changchun TCM University,Jilin 130117,P.R.China;Clinical Observation of the therapeutic efficacy of electric stimulation on points for children's am- blyopia[J];Global Chinese Medicine;2009-01
2 ZHOU Ling-jun,ZHAO Ji-jun(Dept.of Nursing Administration,Shanghai Changhai Hospital,Shanghai 200433,China);Plan of America Low Vision Public Health Education and its Instruction for our Country[J];Journal of Nursing(China);2006-03
3 FAN Wen-yan,WU Jun-fang,WANG Tan,WANG Yan-li,YANG Ting-tong;Significance of Transforming Growth Factor - β1 /Smad3 Signaling Pathways in Rats Embryonic Heart Development[J];Journal of Applied Clinical Pediatrics;2012-13
4 CHEN Wen,PENG Yi-xiang,LI Shao-hua,ZHANG Ming-chang, ZHENG Jun(Department of Ophthalmology,Affiliated Union Hospital of Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430022,China);Discussion on Social Practice with Preventive Strategic Conception during Ophthalmological Clinical Practice Teaching[J];Northwest Medical Education;2007-03
5 ZHAO Kan-xing,SHI Xue-feng. Tianjin Medical University,Tianjin 300070;Tianjin Eye Hospital,Tianjin 300020,China;Progress in research of strabismus and amblyopia in China in the new century[J];Chinese Journal of Ophthalmology;2005-08
6 CHEN Wen,LI Shao-hua,WANG Ling,et al.Department of Ophthalmology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;A Survey of Eyesight among 847 Preschool Children in Qiaokou District of Wuhan[J];Chinese Journal of Rehabilitation;2007-04
7 ;The effect of TCM on the vision and contrast sensitivity in treating infantile amblyopia[J];Clinical Journal of Chinese Medicine;2013-05
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 SUN Li-li,CHANG Qing,LIANG Zhi-qing,SHI Chang-xu (Department of Gynecology and Obstetrics,Southwest Hospital,Third Military Medical University,Chongqing 400038,China);Changes of ANF mRNA expression in the myocardial tissue of rat embryo and suckling induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin[J];Acta Academiae Medicinae Militaris Tertiae;2006-16
2 YANG Yong-bin1,2,ZHENG Ming-hui1,*,LIU Zheng-tao3 1. Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085 2. Experiment Center of Hebei University Health Science Center, Baoding 071000 3. Chinese Research Academy of Environmental Sciences, Beijing 100012;Researching Advancement of the Dioxins Toxicology[J];Asian Journal of Ecotoxicology;2006-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved