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《Journal of Applied Clinical Pediatrics》 2012-23
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Effects of Long-Term Exposure to Polychlorinated Biphenyls of Low Concentrations on Morphology Development of Zebrafish Retinal

WANG Yan-ping1,CHI Xia2,YANG Lei2,GUO Xi-rong2,TONG Mei-ling2 (1.Department of Pediatrics Neurology,Wuxi People′s Hospital,Wuxi 214023,Jiangsu Province,China;2.Department of Pediatrics,Maternal and Child Health Hospital of Nanjing,Nanjing Medical University,Nanjing 210004,Jiangsu Province,China)  
Objective To explore the effects of low concentration of polychlorinated biphenyls(PCBs) on zebrafish retinal morphology which were exposed to it for a long time. Methods The zebrafishes were divided into normal ones(normal control group) and 0.05 mg·L-1 PCBs treatment ones(experimental group).The retinal morphology changes of zebrafish embryos were observed by light and electron microscope after 7,15,30 days separately. Results 1.Under the light microscope:There was no significant difference on the zebrafish retinal morphology between the 2 groups after 7 days and 15 days,while nuclear chromatin margination,cell vacuolization and reducement of the nuclear numbers were observed after 30 days.2.Under the electronic microscope:There was no obvious influence on the outer segment disk of retinal photoreceptor after 7 days and 15 days in experimental group,while less and smaller outer segment disk of retinal photoreceptor,mitochondrial vacuolization and degeneration and the endoplasmic reticulum expansion were observed after 30 days treatment. Conclusions Long-time exposure to low concentrations of PCBs in daily life will do harm to zebrafish retinal development,thus,should be strengthen the monitoring and controlling of organic pollutants in the environment.At the same time,the presence of low concentrations of PCBs around may also have a certain impact on population health.
【Fund】: 国家自然科学基金(81170889);; 江苏省“六大人才高峰”第七批高层次人才项目(2010001);; 南京市医学科技发展基金(YKK10032)
【CateGory Index】: R774.1
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