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《Journal of Applied Clinical Pediatrics》 2012-23
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Effect of Sufentanil Used for Postoperative Analgesia and Sedation with Different Doses in Children and Infants with Congenital Heart Disease

WEI Dan,LIU Ying-long,HE Yan,OU-YANG Chuan,LIU Ya-guang,JIA Qing-yan(Cardiac Intensive Care Unit of Pediatric Cardiac Surgery,Beijing Anzhen Hospital Affiliated to Capital Medical University,Beijing 100029,China)  
Objective To investigate the effect of sufentanil used for postoperative analgesia and sedation with different doses in children and infants with congenital heart disease. Methods Eighty-four patients[mean age 34.2 months(ranged from 3 to 144 months);mean weight 13.1 kg(ranged from 5.0-37.0 kg)] receiving ventricular septal defect repair and(or)atrial septal defect repair from Nov.2010 to Jul.2011 were studied prospectively.The patients were randomly divided into 3 groups with different doses of sufentanil:groupⅠ:0.02 μg·kg-1·h-1,groupⅡ:0.03 μg·kg-1·h-1,group Ⅲ:0.04 μg·kg-1·h-1.The time of extubation,the incidence of nausea and vomiting,the incidence of temporary use of midazolam,the incidence of reintubation because of respiratory depression,heart rate(HR),systolic blood pressure(SBP),respiratory rate(RR),central venous pressure(CVP),blood oxygen saturation(SPO2),Wong-Baker Faces Pain Rating Scale,FLACC Scale,Ramsay scale were compared. Results It was satisfied on sedation and analgesia by using sufentanil from 0.02 μg·kg-1·h-1 to 0.04 μg·kg-1·h-1 postoperatively,the results of sedation and analgesia were good and had no significant difference between 3 groups(P0.05).The HR,SBP,CVP,RR,SPO2 were normal except the RR was higher than that in group Ⅱand group Ⅲ at 24 h after surgery.The time of extubation had no significant difference between 3 groups(P0.05).The incidence of nausea and vomiting were 6.7%,14.8% and 22.2%,respectively and it also had no significant difference between 3 groups(P0.05).The incidence of temporarily use of midazolam were different between 3 groups(P0.05).There was no reintubation because of respiratory depression. Conclusions Sufentanil can be safely used for postoperative sedation and analgesia for congenital heart disease patients,dose of 0.04 μg·kg-1·h-1 had a good effect on pain release and lower incidence of using midazolam temporarily.
【Fund】: 北京市科技计划项目(z111100074911001)
【CateGory Index】: R726.1
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