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《Journal of Applied Clinical Pediatrics》 2012-23
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Effect of Levetiracetam on Serum High-Sensitivity C-Reactive Protein and S100B Protein in Children with Epilepsy

LI Jing (the Second Department of Neurology,Center Hospital in Xinxiang City,Xinxiang 453000,Henan Province,China)  
Objective To study the effectiveness of levetiracetam on serum high-sensitivity C-reactive protein(hs-CRP) and S100B in children with epilepsy. Methods Sixty children with epilepsy were randomly divided into control group(n=30) and the observation group(n=30).The children in the control group were treated with sodium valproate,while the children in the observation group were treated through levetiracetam.The serum hs-CRP and S100B were detected before and after treatment. Results The observation group the condition of 9 cases got controlled,markedly effective in 18 cases,3 cases ineffective.In the control group the condition of 5 cases got controlled,markedly effective in 17 cases,8 cases ineffective.The total effective rate was 90.0% in the treatment group and 73.3% in the control group.There was a significant difference between 2 groups(P0.05).The hs-CRP and S100B were decreased after treatment in both groups.There was a significant difference between 2 groups(P0.05). Conclusions Levetiracetam can improve brain damage through mitigating inflammatory reactions by down regulating the expression of hs-CRP and S100B,and its effect is better than that of sodium valproate.
【CateGory Index】: R742.1
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