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《Journal of Applied Clinical Pediatrics》 2012-24
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Effect of Different Types of Antipsychotics on Serum Homocysteine Level and Cognitive Function in Children with Schizophrenia

DU Yun-hong,MU Jun-lin,ZHANG Zhao-hui,GUO Su-qin(Department of Psychiatry,the Second Affiliated Hospital of Xinxiang Medical University,Xinxiang 453002,Henan Province,China)  
Objective To discuss the effect of antipsychotics on serum homocysteine(Hcy) level and cognitive function in children with schizophrenia.Methods Ninety-six children with primary schizophrenia were divided into typical antipsychotics treatment group and atypical antipsychotics treatment group,and the serum Hcy level and event-related potentials(ERP) of the patients before and after treatment in the 2 groups were detected,after that the results were compared with those in healthy control group(50 healthy cases).Results There was no statistical difference in serum Hcy level and each index of ERP before treatment between the 2 treatment groups,but compared with those in healthy control group,the serum Hcy level was increased,the N2 period latency(PL) and P3PL in ERP were prolonged,and the P3 amplitude(amp) were decreased,and there were significant differences(Pa0.01).Compared with before treatment,the N2PL and P3PL in ERP after treatment in atypical antipsychotics treatment group were decreased,while the P3 amp was increased,and the serum Hcy level was also decreased,and there were significant differences(Pa0.01),but there was no statistical difference of each index after treatment in typical antipsychotics group.After treatment,compared with typical antipsychotics group,the N2 PL and P3PL in ERP in atypical antipsychotics group were shortened,while the P3 amp was increased,but the serum Hcy level was decreased,and there were significant differences(Pa0.01).Conclusions There is a certain degree of high serum Hcy level and cognitive function damage in children with schizophrenia.Atypical antipsychotics treatment can obviously improve the serum Hcy level and cognitive function in patient with schizophrenia.
【Fund】: 河南省医学科技攻关计划项目(201003071)
【CateGory Index】: R749.3
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