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Preliminary approach on relation of childhood asthma with nitric oxide (NO) and cGMP

JIANG Dong-Bo;LI Hua-Qiang;SHI Yuan;PAN Jie;SHEN Ji-Gao;LI Tian-ding; Daping Hospital,(Affiliated to the Third Military Medical University, Chongqing 630042)  
Objectives To search for the potential role of no in the patho-genesis of asthma and its clinical significance.Methods Thirty-three patients with asthma and 20 healthy controls were envolved. NO and cGMP levels were examined. The results were analysed statistically.Results The results showed that before therapy all asthmatic children had increased amounts of NO,cGMP than normal control subjects (P0.001). In which the 9 severe asthmatic children (status asthmaticus) had increased amounts of NO than the 24 mild asthmatic children. After therapy, there was not any significant alteration in the levels of no, cGMP in the asthmatic children and the normal subjects (P0.05).Conclusions The results suggests that increased production of NO in asthmatic children, and the NO produced could cause cytotoxicity and mediate pulmonary epithelial cells damage associated with asthma. Plasma levels of NO may be useful in forecasting the severity of illness.
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