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Clinical significance of serum cojugated glycocholic acid detection in infantile cytomegaiovirus hepatitis

WU Cheng;HUA Shan; LI Lin;YANG Ze Yu; DONG Yang; YE Xue Liang(Anhui Children's Hospital,Hefei, Anhui province, P. R. China)  
Objectives To search for the changes and significance of serum cojugated glycocholic acid(SCG) inthe infantile cytomegalovirus hepatitis (ICMVH).Methods Case control research. There were 20 patients with ICMYH and 20 healthy infants in normal control group. The 20 patients with ICMYH were divided into four stages (acute stage, restorativestage, recover stage, one month after recovery), two groups (congenital aad perinatal infection) and twotypes (severe and mild). The SCG ahas determined by RIA. Serum total bilirubin (STB) and serum glutamic pyruvic transaminase (SGPT) were measure by routine method.The t test and regression analysiswere carried out for the results of determination.Results The results showed that the values of SCG in four stages in ICMYH cases were higher thanthat in normal control group (p0.01), There is obvious variance between two groups and also betweentwo types (P0.05). The results suggested that the changes of SCG shoud be earlier than SGPT. Thebaleds of SCG in 77.8% patients were still higher after the SGPT returned to normal. Conclusion The determination of SCG provides important reference value for the early diagnosis, judgement of patient's condition and prognosis in the ICMVH cases, .and it take the precedence over SGPTin evaluating whether or not the physiological function of liver cells were returned to normal.
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