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Clinical application of relative insulin sensitivity index in children with obesity and diabetes mellitus

WU Wei; ZHAO Li-Hua (Department of pediatrics, First Affiliated Hospital, China Medical University,Shenyang, Lianing Province, P. R. China)(Shenyang Red Cross people's hospital, Shenyang, P. R. China)  
To search for the tissue insulin sensitivity and its relationship to plasma insulin concentration in children with obesity and diabetes mellitus.Methods The plasma glucose and insun concentration (by radioimmunoassay) were determined respectively by glucose oxidase method and radioimmunoassay in 32 children with obesity (16 NGT and 16 IGT),16 children with IDDM, and 16 health children.The relative insulin sensitivity index (RISI) was considered as a index to judge the tissue insulin sensitivity in subjects.Results The values of RISI in obesity group and in IDDM group were significantly lower than that in coutrol group (all p0.01) .The percentage over 0.890 in IGT group and in IDDM group were significantly fewer than that in contrul. group (all P0.01).There was a negative relationship (r=-0.46, p0.01) in obesity group but not in IDDM group between RISI and FPI (r=0.239, P0.05).Conclusions The results reveal that there are the decreased tissue insulin sensitivity,it is a cause of hyperinsulinemia in obesity group.The RISI has practical value on assessment of the tissue sensitivity in IDDM group.
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