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The changes of serum neuro-specific enolase and cranial CT in neonatal hypoxic ischemic encephalopathy

CHENG Hua; ZHANG Shao-Mei; YAO Fu-Bao (Department of Pediatrics, Affiliated Hospital of Xuzhou Medical College)  
To search for the changes of serum neurospecific enolase (NSE) concentration and cranial CT sean in the neonatal hypoxic ischemic encephalopathy (HIE).Methods Twenty neonates of HIE were examined.The concentration of serum NSE was measured by enzyme-linked immunosorbent assay (ELISA) of 3 days and 7 days of life.The cranial CT sean was examined in the first week of life.Results The concentrations of serum NSE at 3 days of life increased in 20 HIE neonates, especilly in moderate and heavy ones, and they were identical with the clinical manifestation.The cramal CT scan showed no differences with the clinical manifestation in them in the light and moderate ones.Conclusions NSE is a reliable marker for early diagnosis of HIE and estimate of hypoxic-ischemic brain damage. The cranial CT saan together with serum NSf are much help for the diagnosis and cure of HIE.
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