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Interference of Physical Exercise Influence Rats with Type 2 Diabetes and Its Marrow Leptin and Leptin Receptor Protein Expression in Different Stage of Morbidity

GAO Haining;WANG Yanjie;ZHAO Danyu;CUI Yong;LIU Chun;CHANG Bo;School of Basic Medicine,Liaoning University of Traditional Chinese Medicine;School of Human Sport Science,Shenyang Sport University;  
Purposes: To provide the theoretic evidence for prevention and treatment for type 2 diabetes by discussing howdoes interference of physical exercise influence rats with type 2 diabetes and its marrowleptin and leptin receptor protein expression in different stage of morbidity. Method: To randomly divide the male SD rats( Weaned) into five groups,each group compromises 11 rats. For instance,group of normal comparison( NCG),group of diabetes comparison( DCG),group of physical exercise treatment( ZLG),group of physical exercise prevention( YFG),group of FZG. Except rats from NCG group fed on normal stuff,the rest groups are fed on fatty and sugary stuff and inject a small does of STX on sixth week,resulted the type 2 diabetes. Group YFG and group FZG are trained to swing for six weeks before the morbidity of type 2diabetes; After the morbidity of type 2 diabetes,group ZLG and group FZG are trained to swing for six weeks. After all groups finished the physical exercises,they are sampled after 12 hours of jejunitas within 24 hours such as FPG,glycocylated serum protein( GSP),Insulin,Osteocalcin( OS) and tartrate resistant acid phosphatase( TRACP) as well as expression of bone metabolism and receptor protein. Results: 1. As for weight,the group ZLG,YFG decreased in comparison with group FZG and group DCG,among which the group ZLG and group FZG have statistical significance( P 0. 05). 2. As for glycometabolism,FPG of group ZLG obviously decreased( P 0. 05) compared with group DCG. Group YFG 's FPG,GSP and Insulin slightly decreased while group FZG decreased sharply in terms of what mentioned above( P 0. 01,P 0.05,P 0. 01). 3. In terms of bone metabolism,group ZLG,group YFG and group FZG's tartrate resistant acid phosphatase( TRACP) presented a decrease,among which the group FZG has statistical significance( P 0. 01); group ZLG,groupYFG and group FZG's Osteocalcin( OS) increased,among which group FZG has statistical significance( P 0. 01). 4. As for bone metabolism and receptor protein,group ZLG,group YFG and group FZG decreased compared with group DCG,among which group FZG has statistical significance( P 0. 01). Conclusions: Interference of physical exercise in different stage of morbidity can improve metabolic disturbance of rats with type 2 diabetes,promote Bone metabolism adjustment,release rebellion of leptin. Hence,it couldn't be better to interfere with physical exercise in the whole process of morbidity.
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