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《Journal of Shaoyang University(Natural Science Edition)》 2018-01
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Clinicopathological Analysis of Diffuse Sclerosing Variant of Papillary Thyroid Carcinoma

WANG Huaxiu;LV Xiaoyuan;School of Medicine,Shaoyang University;  
Objective This study aims to summarize the clinicpathological features of diffuse sclerosing variant of papillary thyroid carcinoma(DSVPTC).Methods Two cases of female DSVPTC samples received histopathological and immunohistochemical analysis,the diagnostic characteristics and differential diagnosis of which were further explored based on this study and previous reports.Results Histopathological observation of DSVPTC samples showed that the tumor diffused into bilateral thyroid tissue accompanied with cervical lymph nodes metastasis.Further microscopic analysis found that the DSVPTC section displayed a diagnostic nuclear features of classic papillary thyroid carcinoma and additional pathological features including extensive squamous metaplasia,abundant gravel bodies,dense lymphocytic infiltration,interstitial fibrosis,etc.Moreover,immunohistochemical detection of TG(+),TTF(+) and CK5/6(+) of this tumor cells all exhibited positive expression,the proliferation index Ki-67 of which was approximately 5%.Conclusion DSVPTC is a rare subtype of papillary thyroid carcinoma.Consequently,the case that lacks cytological characteristics of typical papillary thyroid carcinoma should be differentiated from hashimoto thyroiditis and subacute thyroiditis.DSVPTC is able to be diagnosed by sample collection combined with its clinicopathological features and immunophenotype.
【Fund】: 湖南省教育厅科学研究项目(12C1216);; 湖南省大学生研究性学习和创新性实验计划项目(2012-592)
【CateGory Index】: R736.1
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